2010 Cilt 29 Sayı 2

Permanent URI for this collectionhttps://hdl.handle.net/11452/13939

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Browsing by BUU Author "Aytuğ, Nilüfer"

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    Comparison of the effects of prednisolon, danazol and testosteron propionat therapy in dogs with immune mediated hemolytic anemia and thrombocytopenia
    (Uludağ Üniversitesi, 2010-04-05) Şentürk, Sezgin; Temizel, Mutlu; Cihan, Hüseyin; Aytuğ, Nilüfer; Uludağ Üniversitesi/Veteriner Fakültesi.
    The purpose of the study was to determine and compare the effectiveness of Prednisolon, Danazol and Testosteron propionate in the treatment of 45 dogs with IMHA and IMT. All dogs were selected from dogs diagnosed IMHA and IMT at the Uludag University Faculty of Veternary Medicine, Internal Medicine Clinic, 2003 and 2007 years comprised the animal population of the study. Clinical, biochemical and hematological examination were performed to all dogs during 3 weeks. Dogs in the present study were divided into 3 groups which consisted of 15 dogs. Group I received prednisolone at immunosuppressive doses. Group II received Danazol and also group III received testosterone propionate. The mainly manifesting disturbances in presentation were exercise intolerans, pale mucous membranes, icterus, hemoglobinuria, petechiae and ecchymosis, melena and epistaxis. Hemoglobin and hematocrit levels were significantly higher in group I and II compared with group III at the end of treatment (P=0.05). Thrombocyte counts were within normal reference limits in group I and II at the end of the therapy. In conclusion in this study, despite the normal response to conventional treatment, prednisolone therapy and danazol as synthetic androgen, it was deterimined that there were no anticipated effects by testosterone propionate for treatment of AIHA in dogs.
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    Silent threat: subclinical canine monocytic ehrlichiosis in stray dogs in Turkey
    (Uludağ Üniversitesi, 2010-12-28) Davoust, Bernard; Marie, Jean-Lou; Casalı, Fanny; Parzy, Daniel; Cihan, Hüseyin; Temizel, E. Mutlu; Aytuğ, Nilüfer; Uludağ Üniversitesi/Veteriner Fakültesi.
    Canine monocytic ehrlichiosis has been recognized as an important world-wide canine infectious disease. Thrombocytopenia, leucopenia and normocytic, normochromic anemia are among the major laboratory findings. In this study, 160 stray dogs randomly selected to represent the stray dog population in Ayvalik, Burhaniye, Dikili, Edremit, Bergama region, were tested using IFA to detect antibodies against Ehrlichia canis. The development of methods of in vitro cultivation of E. canis led to the use of the IFA serologic test for detection and titration of anti-E. canis antibodies in dogs. One hundred and eleven of 160 dogs were found seropositive (69.4%) including 69.9% (65/93) of the males and 68.7% (46/67) of the females. There were no significant sex differences. All the dogs were clinically healthy. Thrombocytopenia (<200000 µl-1) was the most common hematological abnormality (p<0,001) (80 %). Total leukocyte counts of the seropositive dogs were lower than in seronegative dogs (p < 0.001), although none of the dogs were leukopenic except in two cases. The results of the present study highlight the importance of canine monocytic ehrlichiosis in Aegean region of Turkey and suggest the need for further impact studies.