2021 Cilt 40 Sayı 2

Permanent URI for this collectionhttps://hdl.handle.net/11452/27899

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Browsing by Subject "Calprotectin"

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    Investigation of Calprotectin positive leukocytes in canine soft tissue tumors
    (Bursa Uludağ Üniversitesi, 2021-08-14) Savaş, Onur; İpek, Volkan
    Soft-tissue sarcomas are a complex group of tumors that are difficult to treat and have high invasion and metastasis potential. Inflammatory cell infiltrations are associated with malignancy in many human and animal tumors. Macrophages and neutrophils are found in inflammatory cells whose infiltration is observed in malignant tumor tissues. Subtypes of these inflammatory cells associated with malignancy and poor prognosis in tumors are called tumor-associated macrophages and tumor-associated neutrophils. In this study, the presence of calprotectin-positive neutrophils and macrophages in canine soft-tissue tumors was investigated using immunohistochemical methods. For this purpose, mesenchymal tumors of different origins from 31 dogs of different breeds, ages, and sexes were examined. After the histopathological classification of the tumors, a comparison was made between benign and malignant tumors in terms of calprotectin-positive macrophages and neutrophils. Calprotectin positivity in malignant soft-tissue tumors was found to be significantly higher than that in benign tumors in the evaluations made on the basis of all positive cells. In the evaluations made only in terms of macrophages, a significant increase in malignant tumors was also noted. No statistically significant difference was found between benign and malignant tumors in terms of neutrophil presence. According to the results in our study, it was observed that calprotectin-positive leukocyte infiltrations could be associated with malignancy in canine soft-tissue tumors.