Person: GÜNAY POLATKAN, ŞEYDA
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GÜNAY POLATKAN
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ŞEYDA
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Publication A nomogram based on myocardial damage and novel inflammatory indexes for post-discharge survival rates of covid-19(Clin Lab Publ, 2022-01-01) Çalışkan, Serhat; Günay, Seyda; GÜNAY POLATKAN, ŞEYDA; Sığırlı, Deniz; SIĞIRLI, DENİZ; Tıp Fakültesi; Kardiyoloji Ana Bilim DalıBackground: In the course of SARS-CoV-2 infection, early prognostic evaluation is important since clinical symp-toms may worsen rapidly and may be fatal. Inflammation plays an important role in the pathogenesis of COVID-19 and can cause myocardial damage which is common in severe COVID-19 patients. Therefore, novel inflamma-tory indexes and myocardial damage may be predictive of prognosis in patients with COVID-19. The aim of the study was to evaluate the role of cardiac troponin I (cTnI), modified Glasgow prognostic score (mGPS), systemic immune inflammation index (SII), prognostic nutritional index (PNI), and CRP to albumin ratio (CAR) in the outcome estimation of COVID-19 and to develop a risk model predicting the survival probability of COVID-19 survivors during early post-discharge. Methods: This was a single-center, observational, retrospective cohort study. Laboratory confirmed COVID-19 patients (n = 265) were included and grouped according to in-hospital mortality. ROC curve analysis was per -formed and Youden's J index was used to obtain optimal cutoff values for inflammatory indexes in discriminating survivors and non-survivors. Cox regression analysis was performed to assess the possible predictors of in -hospi-tal mortality. A nomogram was constructed based on the Cox regression model, to calculate 7-and 14-day surviv-al. Results: The area under the ROC curve (AUC) of the variables ranged between 0.79 and 0.92 with the three highest AUC values for albumin, PNI, and cTnI (0.919, 0.918, and 0.911, respectively). Optimal threshold value for cTnI was 9.7 pg/mL. Univariate analysis showed that gender, albumin, CRP, CAR, PNI, SII, cTnI, and mGPS were significantly related to in-hospital mortality. The Cox regression analysis indicated that mGPS (p = 0.001), CRP (p = 0.026), and cTnI (p = 0.001) were significant prognostic factors. Conclusions: cTnI should not be considered merely as an indicator of myocardial damage. It also reflects the in-flammatory phase and, along with other inflammatory markers, it should be included in risk models as a prognos-tic factor for COVID-19. (Clin. Lab. 2022;68:602-612.Publication The relationship between venous insufficiency and serum magnesium level(John Libbey Eurotext Ltd, 2022-10-01) Çalışkan, Serhat; Atay, Mehmet; GÜNAY POLATKAN, ŞEYDA; Sığırlı, Deniz; SIĞIRLI, DENİZ; Tıp Fakültesi; Kardiyoloji Ana Bilim Dalı; GNH-5913-2022Background: Magnesium is the second most common cation in the cell. In addition to its role as a cofactor in many enzymatic pathways in physiological processes, it is necessary for the regular functioning of vascular smooth muscle cells. Magnesium deficiency has been associated with exacerbation of inflammation, which plays a role in the aetiopathogenesis of many diseases. Aim: To investigate the potential relationship between serum magnesium level and the development of chronic venous insufficiency by comparison with healthy individuals. Methods: The study included 394 patients with venous insufficiency based on physical examination findings and colour Doppler ultrasonography, and 206 controls without venous insufficiency. Venous insufficiency was defined by colour Doppler as reflux lasting 0.5 seconds or more in superficial veins, and longer than one second in femoral and popliteal veins. Clinical, haematological and biochemical parameters, including serum magnesium level and indicators of inflammation, were compared between groups. Results: A total of 600 participants were included. There was no significant difference between the groups in terms of age and gender. In total, 187 (47.46%) patients with chronic venous insufficiency and 105 (50.97%) of the control group were male (p=0.414). The median age of the patients with chronic venous insufficiency was 48 (min-max: 41-49), and the median age of the control group was 49.00 (min-max: 45.00-60.25) (p=0.064). Serum magnesium level was found to be significantly lower in the group with chronic venous insufficiency compared to the control group; 1.90 mg/dL (min-max: 1.82-2) versus 2.1 mg/dL (min-max: 2-2.2) (p<0.001), respectively. Conclusion: Low serum magnesium levels may pose a potential risk for the development of chronic venous insufficiency, which is common in the community.Publication Coronary risk factors and coronary angiography results of 12.257 patients(Elsevier, 2013-10-29) Günay, Şeyda; Serdar, Osman Akın; Özyılmaz, Sinem Özbay; Dereli, Seçkin; Aydınlar, Ali; Baran, İbrahim; Özdemir, Bülent; Yeşilbursa, Dilek; Güllülü, Sümeyye; GÜNAY POLATKAN, ŞEYDA; SERDAR, OSMAN AKIN; Özyılmaz, Sinem Özbay; Dereli, Seçkin; AYDINLAR, ALİ; Baran, İbrahim; ÖZDEMİR, BÜLENT; YEŞİLBURSA, DİLEK; GÜLLÜLÜ, NAZMİYE SÜMEYYE; Tıp Fakültesi; Kardiyoloji Ana Bilim Dalı; 0000-0003-1744-8883; 0000-0002-7788-9739; 0000-0003-0090-3835; AAF-5116-2019; AAG-8709-2020; AAI-5350-2021; AAI-6632-2021; AAJ-3962-2020; AAB-5861-2021; CDA-1396-2022; JHE-3353-2023; EHA-0046-2022; JGR-6552-2023Publication The mysterious light of dark chocolate(Kare, 2015-03-01) Şentürk, Tunay; Günay, Şeyda; ŞENTÜRK, TUNAY; GÜNAY POLATKAN, ŞEYDA; Tıp Fakültesi; Kardiyoloji Ana Bilim Dalı; C-1517-2017; AAI-5350-2021A healthy diet plays a key role in the prevention and management of cardiovascular diseases. Dark chocolate in particular has been shown to improve endothelial functions and lipid profile and to have cardiovascular protective effects via an inhibitory action on platelet functions. Recently, several studies have demonstrated the beneficial effects of chocolate, primarily on hypertension and other conditions such as coronary artery disease and hyperlipidemia. The present review provides a summary of the ingredients, bioavailability and cardiovascular protective effects of chocolate / cocoa and the published effects of chocolate on a number of cardiovascular diseases.Publication Index of cardiac-electrophysiological balance in relapsing-remitting multiple sclerosis patients treated with fingolimod(Elsevier Sci Ltd, 2023-06-16) Günay-Polatkan, S.; GÜNAY POLATKAN, ŞEYDA; SIĞIRLI, DENİZ; Güllü, G.; GÜLLÜ, GİZEM; Sığırlı, Deniz; Koç, E. R.; KOÇ, EMİNE RABİA; Aydınlar, A.; AYDINLAR, ALİ; Turan, O. F.; TURAN, ÖMER FARUK; Tıp Fakültesi; Kardiyoloji Ana Bilim Dalı; 0000-0002-0264-7284; A-7083-2015Background: Fingolimod is indicated for the treatment of relapsing-remitting multiple sclerosis (RRMS) and also targets cardiovascular system due to receptors on cardiomyocytes. Results of previous studies are controversial for the effect of fingolimod in terms of ventricular arrhythmias. Index of cardio-electrophysiological balance (iCEB) is a risk marker for predicting malignant ventricular arrhythmia. There is no evidence on the effect of fingolimod on iCEB in patients with relapsing-remitting multiple sclerosis (RRMS). The aim of this study was to evaluate iCEB in patients with RRMS treated with fingolimod .Methods: A total of 86 patients with RRMS treated with fingolimod were included in the study. All patients underwent a standard 12-lead surface electrocardiogram at initiation of treatment and 6 h after treatment. Heart rate, RR interval, QRS duration, QT, QTc (heart rate corrected QT), T wave peak-to-end (Tp-e) interval, Tp-e/QT, Tp-e/QTc, iCEB (QT/QRS) and iCEBc (QTc/QRS) ratios were calculated from the electrocardiogram. QT correction for heart rate was performed using both the Bazett and Fridericia formulas. Pre-treatment and posttreatment values were compared.Results: Heart rate was significantly lower after fingolimod treatment (p< 0.001). While the post-treatment values of RR and QT intervals were significantly longer (p< 0.001) and post-treatment iCEB was higher (median [Q1Q3], 4.23 [3.95-4.50] vs 4.53 [4.18-5.14]; p< 0.001), it was found that there was no statistically significant change in iCEB and other study parameters derived using QT after correcting for heart rate using both of two formulas.Conclusions: In this study, it was found that fingolimod did not statistically significantly change any of the heart rate-corrected ventricular repolarization parameters, including iCEBc, and it is safe in terms of ventricular arrhythmia.Publication Covid-19 pandemic and anxiety related factors in patients treated in the emergency department(Mre Press, 2020-10-01) Durak, Vahide Aslihan; DURAK, VAHİDE ASLIHAN; Günay, Seyda; GÜNAY POLATKAN, ŞEYDA; Sığırlı, Deniz; SIĞIRLI, DENİZ; Akova, Bedrettin; AKOVA, BEDRETTİN; Armağan, Erol; ARMAĞAN, EROL; Tıp Fakültesi; Spor Hekimliği Ana Bilim Dalı; 0000-0003-0836-7862; 0000-0003-1044-8805; AAA-7472-2021; AAI-4550-2021; AAH-8846-2021; AAI-5350-2021Aims: A novel coronavirus, now known as SARS-CoV-2019, suddenly emerged in Wuhan, China and within threemonths of the initial outbreak, the virus had spread rapidly to neighboring countries causing a pandemic. After the first case was announced, emergency departments were immediately reorganized as pandemic clinics. Special areas with maximum precautions were designed to evaluate patients. The majority of studies on this pandemic have focused on the treatment of respiratory symptoms and comorbidities in intensive care units. In this study, we sought to determine those factors that contributed to the anxiety level during the COVID-19 pandemic using the 'State' subscale of State-Trait Anxiety Inventory (STAI-S). Methods: A survey was performed in the emergency department by using an online questionnaire which consisted of demographic variables, questions about the opinions and behaviors of patients during the pandemic, diagnostic test results for COVID-19, and treatment methods. Results: There was a statistically significant difference between employment status (p < 0.001), monthly income (p < 0.001), the food consumption changes during the pandemic period (p = 0.001) and the estimated end-date for the COVID-19 pandemic (p < 0.001) and total STAI-S points. Conclusions: Our study has identified factors which significantly increase anxiety during the COVID-19 pandemic and identified those individuals who may benefit from psychiatric and social support.Publication Awareness and knowledge of pneumococcal vaccination in cardiology outpatient clinics and the impact of physicians' recommendations on vaccination rates(Mdpi, 2023-04-01) Ekin, Tuba; Kis, Mehmet; Güngören, Fatih; Akhan, Onur; Atıcı, Adem; Kunak, Ayşegül Ulgen; Mutlu, Deniz; Katkat, Fahrettin; Demir, Mevlüt; Sarac, Ibrahim; Soydan, Elton; Karabulut, Dilay; Karaduman, Medeni; Alp, Cağlar; Bekar, Lütfü; Boyuk, Ferit; Adıyaman, Mehmet Sahin; Kaplan, Mehmet; Zengin, İsmet; Çalışkan, Serhat; Kivrak, Tarik; Öz, Ahmet; Eren, Hayati; Bayrak, Murat; Karabulut, Umut; Öztas, Selvi; Duez, Ramazan; Uluuysal, Ömer; Balun, Ahmet; Sağır, Gurur Nar; Kudat, Hasan; Pamukcu, Hilal Erken; Abacioglu, Özge Özcan; Goldag, Ömer Gorkem; Özmen, Caglar; Günay, Şeyda; Zoghi, Mehdi; Ergene, Asim Oktay; Uluuysal, Ömer; GÜNAY POLATKAN, ŞEYDA; Tıp Fakültesi; Kardiyoloji Ana Bilim Dalı; 0000-0003-0012-345X ; IRO-1299-2023; AAI-5350-2021Aim: We aimed to evaluate the awareness of pneumococcal vaccination (PCV13, PPSV23) in general cardiology outpatient clinics and impact of physicians' recommendations on vaccination rates. Methods: This was a multicenter, observational, prospective cohort study. Patients over the age of 18 from 40 hospitals in different regions of Turkey who applied to the cardiology outpatient clinic between September 2022 and August 2021 participated. The vaccination rates were calculated within three months of follow-up from the admitting of the patient to cardiology clinics. Results: The 403 (18.2%) patients with previous pneumococcal vaccination were excluded from the study. The mean age of study population (n = 1808) was 61.9 +/- 12.1 years and 55.4% were male. The 58.7% had coronary artery disease, hypertension (74.1%) was the most common risk factor, and 32.7% of the patients had never been vaccinated although they had information about vaccination before. The main differences between vaccinated and unvaccinated patients were related to education level and ejection fraction. The physicians' recommendations were positively correlated with vaccination intention and behavior in our participants. Multivariate logistic regression analysis showed a significant correlation between vaccination and female sex [OR = 1.55 (95% CI = 1.25-1.92), p < 0.001], higher education level [OR = 1.49 (95% CI = 1.15-1.92), p = 0.002] patients' knowledge [OR = 1.93 (95% CI = 1.56-2.40), p < 0.001], and their physician's recommendation [OR = 5.12 (95% CI = 1.92-13.68), p = 0.001]. Conclusion: To increase adult immunization rates, especially among those with or at risk of cardiovascular disease (CVD), it is essential to understand each of these factors. Even if during COVID-19 pandemic, there is an increased awareness about vaccination, the vaccine acceptance level is not enough, still. Further studies and interventions are needed to improve public vaccination rates.Publication Coronary risk factors and coronary angiography results of 12.201 patients(Elsevier, 2015-07-01) Günay, Şeyda; Serdar, Osman Akın; Özyılmaz, Sinem; Dereli, Seçkin; Aydınlar, Ali; Baran, İbrahim; Özdemir, Burhan; Yeşilbursa, Dilek; Güllülü, Sumeyye; Kaderli, Aysel Aydın; Şentürk, Tunay; GÜNAY POLATKAN, ŞEYDA; SERDAR, OSMAN AKIN; Özyılmaz, Sinem; Dereli, Seçkin; AYDINLAR, ALİ; Baran, İbrahim; Özdemir, Burhan; YEŞİLBURSA, DİLEK; GÜLLÜLÜ, NAZMİYE SÜMEYYE; Kaderli, Aysel Aydın; ŞENTÜRK, TUNAY; Uludağ Üniversitesi; 0000-0003-1744-8883; 0000-0003-0090-3835; 0000-0002-8974-8837; 0000-0003-4829-8400; 0000-0003-0012-345X; AAI-5350-2021; AAI-6632-2021; AAG-8709-2020; AAB-5861-2021; AAJ-3962-2020; C-1517-2017; AAF-5116-2019; CDA-1396-2022; FRF-3343-2022