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ÖZFİLİZ, NESRİN

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ÖZFİLİZ

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2004 - 200912010 - 20151
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    Publication
    Can thoracic sympathetic nerve damage be reversed?
    (Georg Thieme Verlag, 2015-12-01) Erol, M. Muharrem; Salcı, Hakan; Melek, Hüseyin; İlhan, Tuncay; Özfiliz, Nesrin; Bayram, Ahmet Sami; Gebitekin, Cengiz; Erol, M. Muharrem; SALCI, HAKAN; MELEK, HÜSEYİN; İLHAN, TUNCAY; ÖZFİLİZ, NESRİN; BAYRAM, AHMET SAMİ; GEBİTEKİN, CENGİZ; Uludağ Üniversitesi/Tıp Fakültesi/Göğüs Cerrahisi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Cerrahi Anabilim Dalı.; Uludağ Üniversitesi/Veteriner Fakültesi/Histoloji Anabilim Dalı.; 0000-0003-0684-0900; 0000-0003-1822-8153; AAI-5039-2021; AAE-1069-2022; AAH-2756-2021; JCE-0097-2023; AAH-8859-2021; ABB-7580-2020; T-4623-2019; KHE-8874-2024
    Background Function of the thoracic sympathetic chain (TSC) reportedly recovers after surgical clips are removed. Hence, this study was designed to study nerve regeneration after unclipping the TSC.Methods The bilateral TSCs of six goats were studied; the goats were separated into three groups (groups I, II, and III) during excision, clipping, and unclipping. During surgery, the TSCs were excised with a scalpel in group I and clipped in groups II and III. In group III, the clips were removed 1 month postoperatively and observed for possible nerve healing for 1 month. All TSCs were examined histologically following en block resection at 1 month postoperatively in groups I and II and at 2 months postoperatively in group III.Results Inflammation in nerve sections was noted following clip removal. Furthermore, there was significant degeneration and cell infiltration in the nerve fibers of the clipped regions. The Schwann cells around the peripheral nerve endings in the unclipped regions facilitated nerve transmission by reconstitution of myelin.Conclusion Clipping the TSC can cause histologic degeneration; however, histologic nerve regeneration occurs after unclipping.
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    Publication
    Carcinogenic effect of clinoptilolite in rats
    (Indian Veterinary Journal, 2004-01-01) Özbilgin, Şule; Özfiliz, Nesrin; Özbilgin, Şule; ÖZFİLİZ, NESRİN; Uludağ Üniversitesi/Veteriner Fakültesi/Hayvancılık Bölümü; 0000-0002-2940-8988; AAH-2756-2021; R-1336-2019
    Clinoptilolite is a soft, greyish-white natural rock. It contains aluminosilicates with other mixture of minerals. Clinoptilolite products are used for various purposes such as feed additives or dieatary supplements for toxin prevention in farm and poultry breeding animals (Mumpton, 1977; Harvey, 1993). Ozgur et al. (2000) used it as a bedding material for rats and also gave it as 10% and 20% clinoptilolite aqueous solution per os for 6 months and at the end of the experiments toxic effect was not observed in the rats. However, there is inadequate evidence in experimental animals for the carcinogenic potential of clinoptilolite (Tatrai et al., 1993; Adamis et al., 2000). In this study, the induction of mesothelioma was investigated by intrapleural administration of clinoptilolite.