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KAHVECİ, RAMAZAN

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KAHVECİ

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RAMAZAN

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    Publication
    The ki-67 proliferation index predicts recurrence-free survival in patients with dermatofibrosarcoma protuberans
    (Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2021-01-01) Tanriverdi, Ozgur; Ozsen, Mine; ÖZŞEN, MİNE; Deligonul, Adem; DELİGÖNÜL, ADEM; Yazici, Serkan; YAZİCİ, SERKAN; Cetintas, Sibel Kahraman; Yalcinkaya, Ulviye; YALÇINKAYA, ÜLVİYE; Sahin, Ahmet Bilgehan; ŞAHİN, AHMET BİLGEHAN; Orhan, Sibel Oyucu; OYUCU ORHAN, SİBEL; Ocak, Birol; OCAK, BİROL; Evrensel, Turkkan; EVRENSEL, TÜRKKAN; Kahveci, Ramazan; KAHVECİ, RAMAZAN; Cubukcu, Erdem; ÇUBUKÇU, ERDEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Onkoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Plastik Cerrahi ve Estetik Anabilim Dalı.; 0000-0001-6407-0962; 0000-0002-5771-7649; 0000-0002-7846-0870; 0000-0002-0598-7284; 0000-0001-7537-1699; AAJ-8314-2021; AEC-2238-2022; AAM-4927-2020; M-2172-2015
    Dermatofibrosarcoma protuberans (DFSP) is an uncommon soft tissue sarcoma that originates from the dermis or subcutaneous tissue in the skin. While its prognosis is generally favorable, disease recurrence is relatively frequent. Since morbidity after repeated surgery may be significant, an optimized prediction of recurrence-free survival (RFS) has the potential to improve current management strategies. The purpose of this study was to investigate the prognostic value of the Ki-67 proliferation index with respect to RFS in patients with DFSP We retrospectively analyzed data from 45 patients with DFSP. We calculated the Ki-67 proliferation index as the percentage of immunostained nuclei among the total number of tumor cell nuclei regardless of the intensity of immunostaining. We constructed univariate and multivariate Cox proportional hazards regression models to identify predictors of RFS. Among the 45 patients included in the study, 8 developed local recurrences and 2 had lung metastases (median follow-up: 95.o months; range: 5.2-412.4 months). The RFS rates at 60, 120, and 240 months of follow-up were 83.8%, 76.2%, and 65.3%, respectively. The median Ki-67 proliferation index was 14%. Notably, we identified the Ki-67 proliferation index as the only independent predictor for RFS in multivariate Cox proportional hazards regression analysis (hazard ratio = 1.106, 95% confidence interval = 1.019-1.200, p = 0.016). In summary, our results highlight the potential usefulness of the Ki-67 proliferation index for facilitating the identification of patients with DFSP at a higher risk of developing disease recurrences.
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    Outcomes of elderly burn patients requiring hospitalization
    (Taylor ve Francis, 2015-06-01) Şimşek, Muhammed Eren; Özgenel, G. Yeşim; Kahveci, Ramazan; Akın, Selçuk; Özbek, Serhat; Tufan, Fatih; ÖZGENEL, GÜZİN YEŞİM; KAHVECİ, RAMAZAN; AKIN, SELÇUK; ÖZBEK, SERHAT; Uludağ Üniversitesi/Tıp Fakültesi/Plastik, Rekonstrüktif ve Estetik Cerrahi Anabilim Dalı.; 0000-0003-3245-1618; 0000-0003-1683-0722; 0000-0003-0000-8355; AAH-5064-2021; AAH-5441-2021; AAH-4233-2021; AAG-4626-2019
    Background: The elderly population is more likely to be affected by accidents, such as burns, compared to younger populations because of their diminished host defense. There is limited data about the outcomes of elderly burn patients requiring hospitalization.Methods: In this retrospective study, we assessed the epidemiology and outcomes of burn injuries in elderly patients (>60 years old) admitted to a burn unit of a tertiary medical center based on patient characteristics, type and extent of burns, treatment, hospital stay and mortality rates.Results: Forty-eight elderly burn patients among 870 burn patients during the study period were evaluated. Fire was the most common cause of burns (77.1%). Most of the burns involved more than 20% of total body surface area. Twenty-six (54.2%) patients died during hospitalization. Although burn surface area slightly and non-significantly increased in patients over 75 years, there was a significantly increased mortality rate in these patients. Multivariate linear regression analysis revealed burn area and age as independent associates of mortality.Conclusion: Our data show a high mortality rate in elderly burn patients. Extensive burns and increased age seem to increase the mortality risk.
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    Hypothenar hammer syndrome: Case report
    (Medknow Publications & Media, 2014-04-01) ÖZGENEL, GÜZİN YEŞİM; Altınkaya, Süleyman; Özgenel, Güzin Yeşim; Tunalı, Orhan; Kahveci, Ramazan; KAHVECİ, RAMAZAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi; AAG-4626-2019; AAH-4233-2021
    Introduction: Hypothenar Hammer Syndrome is trauma related vascular disease of the hand.Case: A 42-year-old man, manual worker, came to our department with a painful mass in his dominant hand. Physical examination showed pulsatile mass at hypothenar region. Angiography demonstrated ulnar artery pseudoaneurysm.Results: Surgical resection of affected ulnar artery part and reconstruction was performed with vein graft.