Person: GÜLLÜLÜ BOZ, SAİDE ELİF
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GÜLLÜLÜ BOZ
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SAİDE ELİF
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Publication Comparison of the effects of medical and surgical treatments in giant prolactinoma: A single-center experience(Springer, 2021-07-08) Hakyemez, Bahattin; Cander, Soner; CANDER, SONER; Oz Gul, Ozen; ÖZ GÜL, ÖZEN; Eylemer, Eda; Gunes, Elif; Hakyemez, Bahattin; HAKYEMEZ, BAHATTİN; Gullulu Boz, Elif; GÜLLÜLÜ BOZ, SAİDE ELİF; Yilmazlar, Selcuk; YILMAZLAR, SELÇUK; Ersoy, Canan; ERSOY, CANAN; Tıp Fakültesi; AAA-3274-2019Purpose Giant prolactinomas, which have extremely large sizes and high prolactin (PRL) values, are rarely seen. Although medical therapy is effective, surgical treatment is more frequently applied due to slightly lower response rates and compression symptoms. This study aimed to compare the medical and surgical treatment results in giant prolactinomas. Methods Thirty-nine patients who were followed up in our center for giant prolactinoma were included in the study, and the response rates of the patients were evaluated after the medical and surgical treatments. The treatment responses were compared in terms of tumor volume, PRL level, visual field, and pituitary function. Results The outcomes of the 66 treatment periods (medical n = 42; surgical n = 24) in 39 patients (mean age, 47.2 years; men, 89.7%) were evaluated. The most common presentations were hypogonadism and visual defects. The mean longest tumor diameter at diagnosis was 52.2 +/- 11.8 mm, and the median PRL levels were 5000 ng/mL. PRL level normalization was achieved in 69% with medical therapy, and a curative response was obtained in only two patients with surgery. Tumor volume reduction was 67% (no cure) in the medical and 75% (13% cure) in the surgical groups (p = 0.39). Improvement of visual field was 70.8% in the medical and 84.2% in the surgical group (p = 0.12). Conclusion In our study, it was observed that medical therapy was effective and safe in patients with giant prolactinomas. The use of surgical treatment should be limited to prolactinomas with compression or post-resistance to medical treatment in serious cases.Publication Could mesangial c3 deposition be an independent prognostic marker in immunoglobulin a nephropathy?(Oxford Univ Press, 2023-06-01) Çetinkaya, Hakkı; Gürsu, Meltem; Yazıcı, Halil; Cebeci, Egemen; Eren, Necmi; Altıparmak, Mehmet Rıza; Akçay, Ömer Faruk; Şahin, Gülizar Manga; Baştürk, Taner; Atılgan, Kadir Gökhan; Aydemir, Nihal; Turgutalp, Kenan; Dheir, Hamad; Yılmaz, Mürvet; Sıralı, Semahat Karahisar; Tatar, Erhan; Mirioğlu, Şafak; Kazan, Sinan; Aydın, Emre; Aydın, Zeki; Türkmen, Kültiğin; Kutlay, Sim; Karagöz, Ferdi; Ögütmen, Melike Betül; Öztürk, Savaş; Özkan, Oktay; Yıldız, Nuriye; Dinçer, Mevlüt Tamer; Yaşar, Emre; Gök, Mahmut; Türkmen, Aydın; Dede, Fatih; Derici, Ülver; Boz, Saide Elif Güllülü; GÜLLÜLÜ BOZ, SAİDE ELİF; Tıp Fakültesi; Nefroloji Ana Bilim Dalı; JCX-3921-2023Publication Could mesangial c3 deposition be an independent prognostic marker in immunoglobulin a nephropathy?(Springer Heidelberg, 2023-11-10) Çetinkaya, Hakkı; Gürsu, Meltem; Yazıcı, Halil; Cebeci, Egemen; Eren, Necmi; Altıparmak, Mehmet Riza; Akcay, Ömer Faruk; Şahin, Gülizar; Dheir, Hamad; Bastürk, Taner; Atılgan, Kadir Gökhan; Aydemir, Nihal; Turgutalp, Kenan; Yılmaz, Murvet; Sırali, Semahat Karahisar; Tatar, Erhan; Mirioğlu, Şafak; Kazan, Sinan; Aydın, Emre; Aydın, Zeki; Türkmen, Kültiğin; Kutlay, Sim; Karagöz, Ferdi; Öğütmen, Melike Betül; Öztürk, Savaş; Özkan, Oktay; Yıldız, Nuriye; Dincer, Tamer; Yaşar, Emre; Gök, Mahmut; Türkmen, Aydın; Dede, Fatih; Derici, Ülver; Boz, Elif Güllülü; GÜLLÜLÜ BOZ, SAİDE ELİF; Tıp Fakültesi; Nefroloji Ana Bilim Dalı; CHO-7088-2022Background: Immunoglobulin A nephropathy (IgAN) is a common primary glomerulonephropathy. There is evidence that mesangial C3 deposition plays a role in the development of the disease. The aim of this study was to examine the effect of C3 deposition on the prognosis of IgAN patients.Method: The study included 1135 patients with biopsy-confirmed IgAN from the database of the Turkish Nephrology Association Glomerular Diseases Working Group (TSN-GOLD). Patients were excluded from the study if they were aged < 18 or > 75 years or if C3 staining had not been performed in the immunofluorescent analysis. C3 deposition was defined as an immunofluorescence intensity of C3 >= 2 + within the mesangium. The primary endpoints were the development of end-stage renal disease, a 30% decrease in glomerular filtration rate compared to the basal value or an elevation in proteinuria to a nephrotic level (3.5 gr/day).Results: Mesangial C3 deposition was observed in 603 (53.1%) patients. No statistically significant difference was found at baseline between the groups with and without mesangial C3 deposition, as for age, sex, BMI, proteinuria level, or the presence of hypertension. In the follow-up period with a mean duration of 78 months, no significant difference was found between the two groups regarding the primary endpoints (p = 0.43). A significant correlation between C3 deposition and segmental glomerulosclerosis (S1) according to the Oxford MEST-C classification was found (p = 0.001).Conclusion: Although a correlation was observed between mesangial C3 deposition and the S1 MEST-C classification, mesangial C3 deposition was not a prognostic factor in IgAN.Publication Prognostic factors in renal and patient survival in anti-neutrophil cytoplasmic antibody associated vasculitis(Oxford Univ Press, 2023-06-01) Oğuz, Ebru Gök; Gürsu, Meltem; Güllülü, Mustafa; Şahin, Hatice; Pişkinpaşa, Serhan Vahit; Akçay, Ömer Faruk; Çetinkaya, Hakkı; Cebeci, Egemen; Türkmen, Aydın; Trablus, Sinan; Tatar, Erhan; Turgutalp, Kenan; Bek, Sibel; Sahin, Garip; Sipahi, Savaş; Mirioğlu, Şafak; Güngör, Özkan; Kutlay, Sim; Baştürk, Taner; Sipahioğlu, Murat; Yıldırım, Yaşar; Dursun, Belda; Kazan, Sinan; Özelsancak, Rüya; Demirelli, Bülent; Karakan, Şebnem; Yılmaz, Mürvet; Şahin, Idris; Tanrısev, Mehmet; Yadigar, Serap; Tanburoğlu, Derya Başak; Toprak, Zeki; Ayli, Deniz; Kibar, Müge Üzerk; Derici, Ülver; Şahin, Gülizar Manga; Aydın, Mehmet Fethullah; Sumnu, Abdullah; Öztürk, Savaş; Boz, Saide Elif Güllülü; GÜLLÜLÜ BOZ, SAİDE ELİF; Tıp Fakültesi; Nefroloji Ana Bilim Dalı; JCX-3921-2023