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BEKTAŞ HORTOĞLU, MELİKA

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BEKTAŞ HORTOĞLU

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MELİKA

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2020 - 20223
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    Publication
    The evaluation of radiosensitivity in patients with STAT3 deficiency
    (Springer, 2021-04-01) Çekiç, Şükrü; Hüriyet, Hüzeyfe; Hortoğlu, Melika; Barış, Safa; Metin, Ayşe; Özen, Ahmet; Aydıner, Elif Karakoç; Abakay, Candan; Çavaş, Tolga; Kılıç, Sara; ÇEKİÇ, ŞÜKRÜ; Hüriyet, Hüzeyfe; BEKTAŞ HORTOĞLU, MELİKA; DEMİRÖZ ABAKAY, CANDAN; ÇAVAŞ, TOLGA; KILIÇ GÜLTEKİN, SARA ŞEBNEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Anabilim Dalı/Çocuk İmmunoloji Bilim Dalı.; 0000-0002-9574-1842; 0000-0001-8494-601X; 0000-0003-4150-5200; AAA-4154-2022; JBJ-7521-2023; R-6749-2017; L-1933-2017; HKN-1599-2023
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    Publication
    Cancer tendency in a patient with ZNF341 deficiency
    (Springer/Plenum Publishers, 2020-01-20) Çekiç, Şükrü; Hartberger, Julia Maria; Frey-Jakobs, Stefanie; Hüriyet, Hüzeyfe; Hortoğlu, Melika Bektaş; Neubauer, Johanna Charlotte; Karalı, Yasin; Abakay, Candan Demiröz; Saraydaroğlu, Özlem; Çavaş, Tolga; Grimbacher, Bodo; Kılıç, Sara Şebnem; ÇEKİÇ, ŞÜKRÜ; Huriyet, Huzeyfe; BEKTAŞ HORTOĞLU, MELİKA; KARALI, YASİN; DEMİRÖZ ABAKAY, CANDAN; SARAYDAROĞLU, ÖZLEM; ÇAVAŞ, TOLGA; KILIÇ GÜLTEKİN, SARA ŞEBNEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik İmmünoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; 0000-0002-9574-1842; 0000-0003-1620-1918; 0000-0002-6897-6806; 0000-0001-8571-2581; 0000-0002-5617-8313; L-1933-2017; JBJ-7521-2023; AAH-3855-2021; AAA-4154-2022; AAH-1658-2021; AAH-9701-2021; AAH-3508-2021; CVI-9578-2022; FFS-1974-2022
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    Publication
    Increased radiosensitivity and impaired DNA repair in patients with STAT3-LOF and ZNF341 deficiency, potentially contributing to malignant transformations
    (Oxford Univ Press, 2022-05-02) Çekiç, Şükrü; Hüriyet, Hüzeyfe; Hortoğlu, Melika; Kasap, Nurhan; Özen, Ahmet; Karakoç-Aydıner, Elif; Metin, Ayşe; Ocakoğlu, Gökhan; Demiröz Abakay, Candan; Temel, Şehime G.; Özemri Sağ, Şebnem; Barış, Safa; Çavaş, Tolga; Şebnem Kılıç, Sara; ÇEKİÇ, ŞÜKRÜ; Hüriyet, Hüzeyfe; BEKTAŞ HORTOĞLU, MELİKA; OCAKOĞLU, GÖKHAN; DEMİRÖZ ABAKAY, CANDAN; TEMEL, ŞEHİME GÜLSÜN; ÖZEMRİ SAĞ, ŞEBNEM; ÇAVAŞ, TOLGA; KILIÇ GÜLTEKİN, SARA ŞEBNEM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatrik İmmünoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü/Hücre Kültürü ve Genetik Toksikoloji Laboratuvarı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Genetik Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Translasyonel Tıp Anabilim Dalı.; 0000-0002-9574-1842 ; 0000-0002-5617-8313 ; 0000-0001-5380-5898 ; 0000-0003-1620-1918 ; L-1933-2017; CVI-9578-2022; JBJ-7521-2023; HLG-6346-2023; AAH-3855-2021; AAG-8385-2021; AAH-8355-2021; AAH-3508-2021; IMT-6140-2023
    STAT3 plays an important role in various complex and sometimes contradictory pathways such as proliferation, differentiation, migration, inflammation, and apoptosis. The transcriptional activity of the STAT3 gene is controlled by a transcription factor called ZNF341. There is insufficient data on radiation sensitivity and post-radiation DNA repair in STAT3- loss-of-function (LOF) patients. We aimed to investigate the radiosensitivity in patients with STAT3-LOF and ZNF341 deficiency. Twelve patients with STAT3-LOF and four ZNF341-deficiency patients were recruited from three clinical immunology centers in Turkey and evaluated for radiosensitivity by the Comet assay, comparing to 14 age- and sex-matched healthy controls. The tail length (TL) (mu m), percentage of DNA in the tail (TDNA%), and olive tail moment (OTM) (arbitrary units) were evaluated at the same time for baseline (spontaneous), initial (immediately after 2 Gy irradiation), and recovery (2 h after irradiation) periods by using a computerized image-analysis system, estimating DNA damage. Except for a patient with ZNF341 deficiency who developed nasal cell primitive neuroendocrine tumor and papillary thyroid cancer during the follow-up, there was no cancer in both groups. During the recovery period of irradiation, TL, TDNA%, and OTM values of healthy controls decreased rapidly toward the baseline, while these values of patients with STAT3-LOF and ZNF341 deficiency continued to increase, implying impaired DNA repair mechanisms. Increased radiosensitivity and impaired DNA repair were demonstrated in patients diagnosed with STAT3-LOF and ZNF341 deficiency, potentially explaining the susceptibility to malignant transformation.This study demonstrates for the first time that patients with STAT3-LOF and ZNF341 deficiency had increased radiation sensitivity and DNA repair defects compared with healthy controls. Our results highlight the need for close monitoring of these patients for the development of malignancy.