Person: ŞENOL, KAZIM
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ŞENOL
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KAZIM
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Publication Metastatic neoplasms to the breast(Sage Publications Inc, 2023-10-29) Özsen, Mine; Tolunay, Şahsine; Polatkan, Seyit Ali Volkan; Şenol, Kazım; Gökgöz, Mustafa Şehsuvar; ÖZŞEN, MİNE; TOLUNAY, ŞAHSİNE; POLATKAN, SEYİT ALİ VOLKAN; ŞENOL, KAZIM; GÖKGÖZ, MUSTAFA ŞEHSUVAR; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; 0000-0001-6273-0664; JIT-5311-2023; AAI-1612-2021; FSB-8576-2022; KGQ-4411-2024; EWY-5692-2022Objective: When the clinical presentation is related to the metastatic mass and a radiologically solitary tumor focus is detected, especially in cases where clinical information is not taken into account or is insufficient, if a possible metastatic neoplasia is not kept in mind then it is possible to evaluate the tumor as a primary breast neoplasm. In this study, it is aimed to present our cases of non-hematopoietic metastatic neoplasms and to evaluate the clinicopathological features that may aid in distinguishing metastatic from primary neoplasms. Material and Methods: This study includes cases diagnosed with metastatic non-hematopoietic breast neoplasm in breast resection materials in our center, between the years 2010-2023. All cases were analyzed retrospectively by evaluating clinicopathological features. Results: Of the 15 subjects included in the study, 11 (73%) were female and 4 (27%) were male. The mean age of the patients were 46.9 ranged from 22 to 63 years. The most frequent metastatic malignancy was carcinoma (60%), followed by melanoma (33%) and sarcoma (7%). Of the 9 patients with metastatic carcinoma, the primary tumor originated from the lungs in 4, from gastrointestinal system in 2, female genital tract in 2, and kidney in 1 patient. Sarcoma diagnosis was given in a single patient and the histology was a leiomyosarcoma originating from kidney. Conclusion: A careful histomorphological and immunohistochemical evaluation and a detailed examination of the clinicoradiological data are critical to establish the right course in patient management, treatment plan and to correctly predict the prognosis.Publication The positive effects of the human amniotic membrane on the healing of staple line after sleeve gastrectomy applied long-evans rat model(Springer, 2019-11-01) Ferhatoğlu, Murat Ferhat; Kıvılcım, Taner; Şenol, Kazım; Vural, Gürcan; Kartal, Abdulcabbar; İncir, Said; Filiz, Ali İlker; Kebudi, Abut; ŞENOL, KAZIM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı; 0000-0001-6273-0664; KGQ-4411-2024Background The staple line leakage is a dangerous complication of sleeve gastrectomy. Various strategies have been tried to reduce the leakage risk. The amniotic membrane (AmM) is the inner layer of the placental membranes and has anti-inflammatory, anti-fibrosis, and anti-scarring effects, and it also has lower immune characteristics which are another essential characteristic of AmM concerning its utility for grafting. In this study, we aimed to investigate the impact of AmM on the staple line healing process of sleeve gastrectomy model in rats. Materials and Methods We used twenty-eight Long-Evans rats in this study. Sleeve gastrectomy was performed with tristapler. Fourteen rats served as controls, AmM was applied staple line of the other fourteen. Fourteen animals were sacrificed (seven from the AmM applied group and the other seven from the control group) on the third postoperative day. And, the other fourteen animals were sacrificed (seven from the AmM applied group and seven from the control group) on the seventh postoperative day. The tissue around the staple line was evaluated microscopically and macroscopically, bursting pressures and hydroxyproline levels were also measured. Results The bursting pressure and hydroxyproline measurements of the AmM applied group was significantly higher on the seventh postoperative day (p = 0.015, p = 0.012) Fibroblast activity and neoangiogenesis of the AmM applied group was also significantly higher on the seventh postoperative day (p = 0.004, p = 0.002). Conclusion This study showed that covering of staple line of sleeve gastrectomy model in rats significantly provided higher bursting pressures and increased hydroxyproline levels, fibroblast activity, and neoangiogenesis which may potentially lead a better staple line healing. We think further investigations are needed on this issue.Publication Clinical features and short-term outcomes of bariatric surgery in morbidly obese patients: Institutional experience at a rural hospital(Mary Ann Liebert, Inc, 2021-03-01) Şenol, Kazım; Ferhatoğlu, Murat Ferhat; Kocaeli, Aysen Akkurt; Dündar, Halit Ziya; Kaya, Ekrem; ŞENOL, KAZIM; DÜNDAR, HALİT ZİYA; KAYA, EKREM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı; 0000-0002-9562-4195; FVY-2168-2022; EWI-3634-2022; AAG-7319-2021Objective: To prospectively evaluate the postoperative morbidity, mortality, and weight loss evolution of patients who underwent a bariatric procedure during 1 year of follow-up.Methods: Since July 2016, a total of 101 patients' data have been prospectively registered in a database. Comorbidities, operating time, hospital stay, early and late complications rate, and weight loss evolution after 1 year of follow-up were recorded.Results: The mean age was 38.41 +/- 11.05 years with a mean body mass index (BMI) of 49.02 +/- 5.89 kg/m(2) (range 38-67). Laparoscopic sleeve gastrectomy (LSG) was performed in 93 patients (92.07%) and Roux-en-Y gastric bypass (RNYGB) in 8 patients (7.92%). Thirty-day morbidity rate was 7.92% (8/101). Within a mean 9.32 +/- 2.25 (range 1-19) months follow-up time, mean percent of the excess of weight loss of 1st, 6th, and 12th months were 22.7 +/- 6.1, 67.2 +/- 11.2, and 81.4 +/- 10.5, respectively. Diabetes (n = 38, 37.6%), hypertension (n = 13, 12.9%), and obstructive sleep apnea (n = 5, 4.9%) were resolved in 76%, 68.4%, and 100% of the patients, respectively (p < 0.001).Conclusions: LSG and RNYGB are safe and highly effective, particularly in patients with a BMI >50 kg/m(2). Both techniques have been presented with better clinical outcomes regarding significant comorbidity resolution in the early evolution of weight loss.Publication Simple prognostic markers to predict mortality in intensive care unit: Red cell distribution width(Turkish Soc Medical & Surgical Intensive Care Medicine, 2021-04-01) Erdogan, Ahmet; Erdem, Deniz; Uckan, Enes Malik; Tez, Mesut; Senol, Kazim; ŞENOL, KAZIM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; 0000-0001-5282-9492; F-6462-2013; HGB-6844-2022; HQY-3560-2023Background: We tried to examine association between the prognostic intensive care unit (ICU) scores and red cell distribution width (RDW) for prediction of mortality in a cohort of ICU patients at a single centre in Turkey.Methods: This is a retrospective cohort study conducted in a 9-bed mixed ICU of a tertiary hospital from January to December 2013. One hundred and nine ICU patients requiring intensive care following an elective or emergent surgical procedure, trauma or medical severe disease were enrolled in the study. Demographic data, admission clinical parameters and Acute Physiology and Chronic Health Evaluation (APACHE) II, Sequential Organ Failure Assessment (SOFA), Simplified Acute Physiology Score (SAPS) II scores were collected. The primary outcome was ICU mortality which is defined as death before hospital discharge for any reason. Receivers operating characteristic (ROC) curves were used to examine the performance of variables in predicting ICU mortality.Results: There were significant positive correlations between RDW and APACHE II, SOFA and SAPS II scores. RDW levels were significantly higher in non-survivors (16.94 +/- 3.05 versus 15.62 +/- 2.82, p<0.001). The optimal cutoff value of RDW for prediction of mortality according to ROC analyses was 14.5. ICU mortality rate was 18.9% if RDW level was less than 14.5%; and 81.1 % if RDW level was greater than14.5%.Conclusions: We found that ICU mortality was higher RDW was greater than 14.5%. We also found positive correlation between RDW and ICU mortality scores.Publication Outcomes of marginal grafts in cadaveric liver transplantation(Lippincott Williams & Wilkins, 2021-08-01) Taşar, Pınar; Dündar, Halit Ziya; Sığırlı, Deniz; Şenol, Kazım; Çelik, Fatih; Selimoglu, Kerem; İşçimen, Remzi; Kıyıcı, Murat; Kaya, Ekrem; TAŞAR, PINAR; DÜNDAR, HALİT ZİYA; SIĞIRLI, DENİZ; ŞENOL, KAZIM; Çelik, Fatih; Selimoğlu, Kerem; İŞÇİMEN, REMZİ; KIYICI, MURAT; KAYA, EKREM; Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Bölümü; Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Cerrahi Bölümü; Uludağ Üniversitesi/Tıp Fakültesi/Anestezi ve Reanimat Bölümü; Uludağ Üniversitesi/Tıp Fakültesi/Gastroenteroloji Bölümü; 0000-0001-6273-0664; 0000-0003-2728-9521; 0000-0003-3635-7282; IIC-9825-2023; EWI-3634-2022; KGQ-4411-2024; JYY-5340-2024; CDS-3299-2022Publication Metformin promotes apoptosis in primary breast cancer cells by downregulation of cyclin D1 and upregulation of P53 through an AMPK-alpha independent mechanism(Türk Tıp Bilimleri Dergisi, 2021-01-01) Yenmiş, Güven; Beşli, Nail; Saraç, Elif Yaprak; Emre, Fatma Sinem Hocaoğlu; Şenol, Kazım; Sultuybek, Gönul Kanıgur; ŞENOL, KAZIM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı; 0000-0001-6273-0664; KGQ-4411-2024Background/aim: In the present study we aimed to figure out the effect of metformin on the expression of AMPK-alpha, cyclin D1, and Tp53, and apoptosis in primary breast cancer cells (PBCCs).Materials and methods: PBCCs were treated with two doses of metformin (0 mM, 25 mM). Proliferation was determined by BrdU as-say. Real-time PCR was used to assess AMPK-alpha, cyclin D1, and Tp53 gene expressions; apoptotic indexes of PBCCs were analyzed using flow-cytometry.Results: Twenty-four-hour incubation with 25 mM metformin reduced the proliferation of PBCCs. AMPK-alpha gene expression in PBCCs was not affected by 25 mM metformin treatment compared with the control group. PBCCs treated with 25 mM metformin had lower cyclin D1 expression compared with nontreated cells; however, the difference was not statistically significant. Twenty-five mil-limolar dose of metformin increased p53 expression significantly compared with the nontreated group. The high concentration of met -formin elevated the number of annexin V-positive apoptotic cells, and the increase in the apoptotic index was statistically significant.Conclusion: Metformin can modulate cyclin D1 and p53 expression through AMPK-alpha-independent mechanism in breast cancer cells, leading to cell proliferation inhibition and apoptosis induction.Publication Primary tumor surgery in patients with de novo bone-only stage IVA/B breast cancer: Mets: Protocol MF22-03, combination data analysis of prospective studies(Springer, 2023-06-01) Göktepe, Berk; Demirörs, Berkay; Şenol, Kazım; Özbaş, Serdar; Cabioğlu, Neslihan; Sezgin, Efe; Soran, Atilla; ŞENOL, KAZIM; Uludağ Üniversitesi; DSQ-5587-2022Publication Identification of CHEK2 germline mutations in BRCA1/2- and PALB2-negative breast and ovarian cancer patients(Karger, 2022-08-01) Aksoy, Fuat; Tezcan Ünlü, Havva; Çeçener, Gülşah; Güney Eskiler, Gamze; Egeli, Ünal; Tunca, Berrin; Efendi Erdem, Ecem; Şenol, Kazım; Gökgöz, Mustafa Şehsuvar; AKSOY, FUAT; Tezcan Ünlü, Havva; ÇEÇENER, GÜLŞAH; EGELİ, ÜNAL; TUNCA, BERRİN; Efendi Erdem, Ecem; ŞENOL, KAZIM; GÖKGÖZ, MUSTAFA ŞEHSUVAR; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; 0000-0001-5808-9384; 0000-0002-0910-4258; 0000-0002-3820-424X; 0000-0001-7904-883X; 0000-0002-1619-6680; 0000-0001-6273-0664; HII-8895-2022; AAP-9988-2020; GYU-0252-2022; AAH-1420-2021; ABI-6078-2020; GWP-6104-2022; KGQ-4411-2024; EWY-5692-2022Introduction: The CHEK2 gene is known to be an important signal transducer involved in DNA repair, apoptosis, or cell cycle arrest in response to DNA damage. The mutations in this gene have been associated with a wide range of cancers, both sporadic and hereditary. Germline CHEK2 mutations are linked to an increased risk of breast cancer. Therefore, the aim of this study was to identify the prevalence of CHEK2 variants in BRCA1/2- and PALB2-negative early-onset patients with breast cancer and/or ovarian cancer in a Turkish population for the first time. Methods: The study included 95 patients with BRCA1/2- and PALB2-negative early-onset breast cancer and/or ovarian cancer and also 60 unaffected women. All the intron/exon boundaries and coding exons of CHEK2 were subjected to mutational analysis by heteroduplex analysis and DNA sequencing. Results: A total of 16 CHEK2 variants were found in breast cancer patients within the Turkish population. CHEK2 c.1100delC mutation most frequently studied in the CHEK2 gene was not detected in our study. The prevalence of variants of uncertain significance in CHEK2 was found to be 7.3% (n = 7) in BRCA1/2 and PALB2 mutation-negative Turkish patients with early-onset breast and/or ovarian cancer. Conclusion: The present study may shed light on alternative variations that could be significant for understanding the prevalence and clinical suitability of the CHEK2 gene.Publication Aso visual abstract: Intervention for hepatic and pulmonary metastases in breast cancer patients-prospective, multi-institutional registry study: Imet; protocol mf 14-02(Springer, 2022-08-06) Soran, Atilla; Özbaş, S.; Özcınar, B.; Isık, A.; Doğan, L.; Dağ, A.; Karanlık, H.; Aytaç, O.; Karadeniz Çakmak, G.; Dalcı, K.; Doğan, M.; Sezer, Y. A.; Özyar, E.; Sezgin, E.; GÖKGÖZ, MUSTAFA ŞEHSUVAR; Senol, Kazım; ŞENOL, KAZIM; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.Publication Retrospective analysis of prognostic factors affecting the recurrence and disease-free survival following surgical management of gastrointestinal stromal tumors(Turkish Surgical Assoc, 2020-06-01) Özdemir, Gül Dağlar; Akat, Arif Zeki; Kama, Nuri Aydın; Şenol, Kazım; ŞENOL, KAZIM; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0001-6273-0664Objective: The aim of this study was to evaluate the prognostic factors effecting recurrence risk and disease-free survival of the patients who were diagnosed as gastrointestinal stromal tumor after complete resection of the tumor with or without adjuvant therapy.Material and Methods: Between the years 2005 and 2013, data of 71 patients including clinical and demographic features, tumor localizations, pathologic examinations, survival and recurrence rates were enrolled into this retrospective study.Results: Male/female ratio was 1.71, and mean age was 60.27 +/- 14.65 years. Forty-two (59.2%) patients had tumor in stomach, 16 (22.5%) in small bowel, whereas 12 (16.9%) had extra-gastrointestinal system and one patient (%1.4) had rectal localization. Modified NIH risk stratification scheme categorized 9 (12.68%) patients in very low-, 12 (16.90%) in low-, 21 (29.58%) patients in moderate-and 29 (40.85%) patients in high-risk group. Twenty-four (33.8%) patients had a metastatic disease at follow-up while 13 (18.3%) patients were metastatic at admission. RO resection was successfully performed in 51 (71.8%) patients, while R1 resection in 9 (12.7%) and R2 resection in 11 (15.5%) were achieved. Mean follow-up time was 47.12 +/- 33.52 months (range, 1-171 months). Nineteen (26.8%) patients demonstrated recurrence with a mean time of 22.16 +/- 15.89 months (range, 3-57 months). During follow-up 17 (23.9%) patients were deceased. In univariate analysis, high-risk group, small bowel and extra-gastrointestinal system localization, R1-2 resection, necrosis, positive resection margin and invasion of surrounding tissues, metastatic disease and adjuvant therapy were statistically significant in terms of recurrence. Multivariate analysis presented small bowel and extra-gastrointestinal system localization, R2 resection, mitoses count, invasion and adjuvant therapy as independent prognostic risk factors affecting disease-free survival rates.The 1,3 and 5 years of disease-free survival rates of the patients were 89.6%, 75.4%, 64.3%, respectively.Conclusion: As mentioned in the literature, the mainstay of curative therapy of gastrointestinal stromal tumor is surgery. In our study, not only small bowel, extra-gastrointestinal system localization and invasion of surrounding tissues by tumor, but also R2 resection that complicate the local control of the disease were represented as independent adverse prognostic factors for disease-free survival. Unfavourable clinical outcomes of adjuvant therapy over the disease-free survival was linked to higher tumor stage with metastatic disease and emphasized that prospective trials with more cases should be practiced.