Person: YALÇIN, YAKUP
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YALÇIN
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YAKUP
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Publication Clinical significance of risk-reducing salpingo-oophorectomy in patients with BRCA1/2 mutation(Elsevier, 2023-10) Abay, Merve; Özgen, Levent; Yalçın, Yakup; Özerkan, Kemal; ABAY, MERVE; ÖZGEN, LEVENT; YALÇIN, YAKUP; ÖZERKAN, KEMAL; Tıp Fakültesi; Kadın Hastalıkları ve Doğum Ana Bilim Dalı; 0000-0003-0070-2646; CAK-3842-2022; JFT-0660-2023; HQP-3191-2023; AAH-9791-2021Objective: Serous tubal intraepithelial carcinoma (STIC) is a precursor lesion which is located in the distal fallopian tube and causes high grade serous ovarian carcinoma (HGSOC). The incidence of STIC for women underwent risk reducing salpingo-oophorectomy for BRCA mutation varies from 0.6 to 7% and its clinical outcomes are still unclear. The aim of this study was to demonstrate the incidence of STIC and HGSOC in BRCA1/2 mutation carriers after risk reducing salpingo-oophorectomy (RRSO) and the clinical outcomes of these patients. Material and methods: We retrospectively reviewed the records of 48 BRCA1 and/or 2 mutation carriers who underwent prophylactic salpingo-oophorectomy with or without hysterectomy at the Department of Obstetrics and Gynecology, Bursa Uludag University between January 2000 and January 2022. Inclusion criteria: BRCA 1 and/or 2 mutation carriers diagnosed by genetic testing, asymptomatic patients with no abnormal findings on pelvic examination. Exclusion criteria: patients with no abnormal findings on pelvic examination and a presence of a personal history of ovarian, fallopian tube or peritoneal cancer. Results: A total of 48 BRCA 1 and/or 2 mutation carriers underwent RRSO. STIC was diagnosed in 1 (2,0%) patient and restaging surgery was not performed. Primary peritoneal carcinoma (PPC) did not develop during the 20 months follow-up period. One (2.0%) patient was diagnosed with occult ovarian cancer. Restaging surgery was performed and chemotherapy treatments were given after surgery. A pelvic recurrence developed 25 months after the occult cancer diagnosis in the follow up period. One (2.0%) patient with normal histopathological findings after RRSO was diagnosed with peritoneal cancer 57 months after the operation. Conclusion: The risk of PPC continues after RRSO. Therefore, close follow-up procedure is very important for early diagnosis and effective treatment of patients with PPC after RRSO.Publication Clinicopathologic and surgical analysis of 1090 patients with borderline ovarian tumors: A Turkish society gynecologic oncology (TRSGO) multi-institutional retrospective trial(BMJ Publishing Group, 2023-09-01) Güvenal, Tevfik; Demirkıran, Fuat; Şimşek, Erkan; Yalçın, Yakup; Khatib, Ghanim; Gökulu, Şevki Göksun; Şimşek, Tayup; Dolapçıoğlu, Kenan; Onan, Anıl; Özgül, Nejat; Ortaç, Fırat; Yüksel, Hasan; Altıntaş, Aytekin; Boso, Banu; Seyfettinoğlu, Sevtap; Çelik, Çetin; Ureyen, Işin; Yalcin, Ibrahim; Güngördük, Kemal; Şentürk, Baki; Ayhan, Ali; YALÇIN, YAKUP; Tıp Fakültesi; Kadın Hastalıkları Ana Bilim Dalı; Onkoloji Bölümü; HQP-3191-2023Publication Impact of uterine adenomyosis on survival outcome of patients with non-endometrioid endometrial cancer(Bmj Publishing Group, 2023-09-01) Özgen, Levent; ÖZGEN, LEVENT; Yalçın, Yakup; YALÇIN, YAKUP; Özerkan, Kemal; ÖZERKAN, KEMAL; Abay, Merve; ABAY, MERVE; Tıp Fakültesi; Cerrahi Tıp Bilimleri Ana Bilim DalıPublication Evaluation of vulvar squamous cell and glandular cell cancers, retrospective multicenter study(BMJ Publishing Group, 2023-09-01) Güngördük, Kemal; Demirkıran, Fuat; Khatip, Ghanim; Öz, Murat; Tosun, Yağmur Minareci Özgür; Taşkın, Salih; Akman, Levent; Özçelik, Varol Gülseren Bülent; Doğan, Selen; Yalçın, Yakup; Cebi, Şükrü; Vatansever, Doğan; Özarkan, Kemal; Terek, Coşan; Aslan, Koray; Sancı, Muzaffer; Ortaç, Fırat; Vardar, Mehmet Ali; Ayhan, Ali; Arvas, Macit; YALÇIN, YAKUP; Uludağ Üniversitesi; HQP-3191-2023