Person: ÇETİNTAŞ, SİBEL
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ÇETİNTAŞ
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SİBEL
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Publication Improving locoregional outcome in high-intermediate-risk and high-risk stage i endometrial cancer with surgical staging followed by brachytherapy(Korean Soc Therapeutic Radiology & Oncology, 2022-06-01) Arslan, Sonay; Abakay, Candan Demiröz; DEMİRÖZ ABAKAY, CANDAN; Çetintaş, Sibel; ÇETİNTAŞ, SİBEL; Kurt, Meral; KURT, MERAL; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.Purpose: This study aims to assess the locoregional efficacy of postoperative vaginal brachytherapy (VBT) alone in patients undergoing surgical staging for early-stage high-intermediate-risk (HIR) and high-risk (HR) endometrial cancer.Materials and Methods: One hundred and four patients with early-stage HIR and HR endometrial cancer who underwent surgical staging were treated with adjuvant VBT alone. The patients with stage lb, grade I-III, stage la, grade III, lower uterine segment involvement, and lymphovascular invasion (LVI) were included to study.Results: The 5- and 10-year overall survival (OS) rates were 87% and 76%, respectively. The 5- and 10-year DFS rates were 86 0 10 and 86%, respectively. Among the patients, 92 % had endometrioid adenocarcinoma, 2% had undifferentiated carcinoma, 2 % had serous papillary carcinoma, and 4 % had clear-cell carcinoma. Of the patients, 6396 had stage lb disease, while 3796 had stage la disease. None of the patients had vaginal or pelvic lymph node recurrence, whereas two had para-aortic lymph node metastasis, one had surgical scar recurrence, one had para-aortic lymph node and brain metastasis, and one had lung metastasis. The presence of lymphatic invasion was found to be a statistically significant prognostic factor for increased distant metastasis rates (p = 0.020). Lymphatic invasion was also regarded as an independent prognostic factor for metastasis-free survival (p = 0.044).Conclusion: Our study results suggest that postoperative VBT alone is an effective and safe treatment modality with low complication in patients undergoing surgical staging for HIR and HR endometrial cancer.Publication Efficacy of single-dose radiotherapy in preventing posttraumatic tendon adhesion(Springernature, 2020-06-02) Ermutlu, Cenk; ERMUTLU, CENK; Kaleli, Tufan; KALELİ, HÜSEYİN TUFAN; Yalçınkaya, Ulviye; YALÇINKAYA, ÜLVİYE; Çetintaş, Sibel; ÇETİNTAŞ, SİBEL; Atıcı, Teoman; ATICI, TEOMAN; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Ortopedi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolijisi Anabilim Dalı.; 0000-0001-8259-3695; 0000-0003-1109-8958; 0000-0002-3396-3407; AAH-8924-2021; AAB-6136-2022; A-5095-2018; AAB-2795-2021Background and AimPosttraumatic peritendinous adhesion is the greatest obstacle to achieve normal tendon function following lacerations of extrinsic flexor tendons of the hand. In this study, we aimed to evaluate whether single-dose radiotherapy (RT) has the potential to modulate intrasynovial tendon adhesions.Materials and MethodsA total of 80 tendons from the third to fourth flexor profundus of both hind paws of 20 adult New Zealand rabbits were used in this study. Rabbits in the RT group received 3 Gy of X-irradiation in a single fraction. Histopathological evaluation of longitudinal sections of tendons was made using the Tang grading system for peritendinous adhesions. Intratendinous quality of the healing tissue in the laceration zone was assessed using a modified Movin scale.ResultsAdhesion and inflammatory response were greater in the RT group (p(<)0.001). Tendon healing in the radiation group was found to he more uniform and organized compared with the control group. However, this difference was not statistically significant. The nuclei of the tenocytes in the radiation group showed a closer resemblance to normal tendon tissue when compared with the control group (p=0.007).ConclusionsDespite RT's certain advantages such as extracorporeal use, anti-inflammatory effect, and homogenous tissue penetration, 3-Gy X-irradiation resulted in increased peritendinous posttraumatic adhesion, possibly due to dose imbalance. Increased roundness in the tenocyte nuclei was present in the RT group. Studies with different dosing regimens and a higher number of subjects are necessary to establish an ideal dose suppressing the synovial response without compromising tendon healing.Publication An evaluation of the effects of hemoglobin levels on the efficacy of treatment and survival in patients with bladder cancer(Elsevier, 2004-01-01) Kurt, Meral; Canki, N; Çetintaş, SK; Saruhan, S; Yavaşcaoğlu, İsmet; Küçük, N.; Engin, K; KURT, MERAL; Canki, N.; ÇETİNTAŞ, SİBEL; Saruhan, S.; YAVAŞCAOĞLU, İSMET; Küçük, N.; Engin, K.; Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi; 0000-0002-5139-2484; AAA-3961-2020; AAA-7047-2020; ENQ-8539-2022; DOZ-9697-2022; EIN-0828-2022; DBW-9088-2022; CQB-5826-2022Publication Induction chemotherapy and concomitant chemoradiotherapy (CRT) in patients with unresectable, locally advanced pancreatic carcinoma(Amer Soc Clinical Oncology, 2004-07-15) Kurt, Meral; Kurt, Engin; Çetintaş, Sibel; Evrensel, Türkan; Manavoğlu, Osman; Engin, Korkmazer; KURT, MERAL; Kurt, Engin; ÇETİNTAŞ, SİBEL; Evrensel, Türkan; Manavoğlu, Osman; KORKMAZ, ENGİN; Uludağ Üniversitesi; 0000-0002-9732-5340; AAA-7047-2020; AAA-3961-2020; AAJ-1027-2021; FFO-4769-2022; AAJ-1027-2021Publication Dosimetric comparison of multileaf and fixed cone collimator plans with cyberknife(Elsevier Ireland Ltd, 2023-05-01) Abakay, C. Demiröz; DEMİRÖZ ABAKAY, CANDAN; Kiray, Z.; Kurt, Meral; KURT, MERAL; Çetintaş, S.; ÇETİNTAŞ, SİBEL; Bursa Uludağ Üniversitesi/Tıp Fakltesi/Onkoloji Anabilim Dalı.Publication Prediction of breast cancer metastasis risk using circulating tumor markers: A follow-up study(Assoc Basic Medical Sci Federation Bosnia & Herzegovina Sarajevo, 2019-01-01) Çetintaş, Sibel; Tezcan, Gülçin; Tunca, Berrin; Egeli, Ünal; Gökgöz, Mustafa Şehsuvar; Çecener, Gülsah; ÇETİNTAŞ, SİBEL; TUNCA, BERRİN; EGELİ, ÜNAL; GÖKGÖZ, MUSTAFA ŞEHSUVAR; ÇEÇENER, GÜLŞAH; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.; 0000-0002-1619-6680; 0000-0001-7904-883X; 0000-0002-3820-424X; EWY-5692-2022; AAA-7047-2020; AAH-1420-2021; ABI-6078-2020; AAP-9988-2020Distant organ tumor dissemination is a major cause of breast cancer-related deaths. In 2010, we analyzed the prognostic importance of the circulating tumor markers (CTMs) cytokeratin 19 (CK19), CK20, epidermal growth factor receptor (EGFR) and human epidermal growth factor receptor 2 (HER2) in relation to the clinical and pathological characteristics of patients with breast cancer (BC). To assess the clinical utility of CK19, CK20 and EGFR in predicting distant metastasis in BC, here we report 7-year follow-up results of 77 patients. The patients with at least one positive CTM were classified as CTM(+) and those negative for all CTMs were assigned to CTM(-) group. In patients who received no treatment following CTM analysis, 25.0% had metastasis in CTM(+) and 10.0% in CTM(-) group. In patients who received one of the following therapies: chemotherapy, radiotherapy or hormone therapy, or the combinations of these therapies, the rate of metastasis was 33.3% in CTM(+) and 20.0% in CTM(-) group. Disease-free time was shorter in CTM(+) patients compared to CTM(-) group (28.83 +/- 10.76 and 41.38 +/- 9.5 months, respectively). According to multivariate Cox proportional hazard regression analysis, the presence of regional lymph node metastasis, Ki-67 expression, higher tumor grade and CTM expression status were predictors of poor prognosis associated with distant metastasis (p < 0.05). Also, CTM positivity was a factor associated with metastasis-related poor prognosis (HR = 0.492, p = 0.026). The mean survival for CTM(+) patients was shorter than that for CTM(-) patients (90.671 +/- 2.66 and 101.23 +/- 3.92 months, respectively; p > 0.05). Our findings demonstrate that CTM positivity may indicate a high metastasis risk; however, CTM negativity does not guarantee low metastasis risk. These results may encourage further preclinical investigation of CTMs, to evaluate the possible implications of these findings to the clinical setting.