Person: KAYA, MURAD
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Publication Sepsis episodes caused by pressure injuries in critical illness: A retrospective observational cohort study(Hmp, 2023-11-01) Kaya, Pınar Küçükdemirci; Kaya, Murad; Girgin, Nermin Kelebek; Kahveci, Ferda S.; Akalın, Emin Halis; İsçimen, Remzi; KÜÇÜKDEMİRCİ KAYA, PINAR; KAYA, MURAD; KELEBEK GİRGİN, NERMİN; KAHVECİ, FERDA ŞÖHRET; AKALIN, EMİN HALİS; İŞÇİMEN, REMZİ; Bursa Uludağ Üniversitesi/Tıp Fakültesi.; 0000-0002-8428-8245; 0000-0002-5882-1632; JGB-6637-2023; CYJ-4124-2022; DTU-3148-2022; IMY-6211-2023; AAU-8952-2020; DWL-9897-2022BACKGROUND: Critically -ill patients (CIPs) with pressure injuries (PIs) may develop bloodstream infections (BSIs). PURPOSE: To identify predisposing factors and discuss diagnosis and management of sepsis -related PIs in CIPs. METHODS: The records of CIPs in the intensive care unit (ICU) between January 1, 2014, and January 1, 2020, with PI with sepsis -diagnoses and with different site cultures that were positive concurrent with bloodstream -cultures were retrospectively reviewed. RESULTS: Ninety-one sepsis episodes were included in the study. Low albumin level ( U = 382.00, P = .006), renal failure (odds ratio [OR], 0.108 [95% CI, 0.015-0.783]; P = .025), and length of ICU stay ( U = 130.00, P < .001) were identified as risk factors of BSIs due to PIs. The probability of BSI during a sepsis episode was lower in CIPs with PIs with higher C -reactive protein levels ( U = 233.00, P < .001) and whose injury resulted from trauma or surgery (OR, 0.101 [95% CI, 0.016-0.626]; P = .014). The mortality was higher in CIPs with PI -induced BSIs (OR, 0.051 [95% CI, 0.008-0.309]; P = .001). CONCLUSIONS: Pressure injury -induced sepsis was associated with a high risk of 28 -day mortality. The findings suggest that CIPs with PI are at increased risk of BSIs if they have low albumin levels, renal -failure, and prolonged ICU stay during sepsis episodes.Publication Are the tidal volumes used in intensive care units suitable for lung protective ventilation? Can training ensure compatibility?(Galenos Yayincilik, 2020-09-01) Kaya, Pınar Küçükdemirci; Sayan, Halil Erkan; Girgin, Nermin Kelebek; KELEBEK GİRGİN, NERMİN; Kaya, Murad; KAYA, MURAD; Bursa Uludağ Üniversitesi/Tıp Fakültesi; 0000-0002-5882-1632Objective: Low tidal volume (VT) and lung protective ventilation (LPV) are recommended to prevent lung injury associated with invasive mechanical ventilation (IMV). Present study aimed to determine the patients with risk of high VT application, whether VT calculated according ideal body weight (IBW) values are suitable for the recommended (6-8 mL/kg) and whether a questionnaire on the issue contributes to IMV suitable for LPV.Materials and Methods: Present study is conducted as a multicenter point - prevalence study in the intensive care units of three hospitals in Bursa. Non-ARDS patients receiving IMV and patients who were older than 18 years were included in the study. IMV parameters and demographic data of the patients were collected. Then, the physicians responsible of ventilatory management completed a questionnaire about LPV strategies and VT values required according to the IVA were shown. After 24 hours, mechanical ventilation parameters were re-collected. Body mass index (BMI), average tidal volume applied [VTmean = minute volume (MV)/respiratory rate (RR)] and VTmean for IBW (VTmean/IBW) values were calculated.Results: Fifty-six patients were included in the study. There were 33 male patients (58.9%) and the mean age of the patients was 65.43 +/- 18.87 years. The mean BMI of the patients was 27.84 +/- 7.0. The most commonly used ventilation mode was synchronized intermittent mandatory ventilation (75%). The VTmean was 549.32 +/- 151.00 mL (VTmean/IBW =9.31 +/- 3.07 mL/kg). According to VTmean/IBW, for the use of large VTs, being female (10.77 +/- 2.74 mL/kg) and having BMI >= 30 (10.82 +/- 3.80 mL/kg) posed significantly higher risk than being male (8.31 +/- 2.91 mL/kg) and having BMI <30 (8.67 +/- 2.47 mL/kg) (p=0.002, p=0.015 respectively). The results showed a significant decrease (p=0.026) in VTmean/IBW (8.81 +/- 3.49 mL/kg) values after the physicians completed LPV questionnaire and were shown the VT values (predicted by IBW).Conclusion: VTmean/IBW values were found to be higher than 6-8 mL/kg, the recommended value for LPV. Ventilation with high VT was associated with female gender and having a BMI of >= 30. Completing the LPV questionnaire and seeing the VT values (predicted by IBW) contributed to the number of the patients ventilated with VT values suitable LPV.Publication Sepsis episodes caused by pressure injuries in critical illness: A retrospective observational cohort study(Hmp, 2023-11-01) KELEBEK GİRGİN, NERMİN; Girgin, Nermin Kelebek; Kaya, Pınar Küçükdemirci; KÜÇÜKDEMİRCİ KAYA, PINAR; Kahveci, Ferda S.; İşcimen, Remzi; İŞÇİMEN, REMZİ; Kaya, Murad; KAYA, MURAD; Akalin, Emin Halis; AKALIN, EMİN HALİS; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Anestezi ve Reanimasyon Anabilim Dalı.; 0000-0002-8428-8245; 0000-0002-5882-1632BACKGROUND: Critically -ill patients (CIPs) with pressure injuries (PIs) may develop bloodstream infections (BSIs). PURPOSE: To identify predisposing factors and discuss diagnosis and management of sepsis -related PIs in CIPs. METHODS: The records of CIPs in the intensive care unit (ICU) between January 1, 2014, and January 1, 2020, with PI with sepsis -diagnoses and with different site cultures that were positive concurrent with bloodstream -cultures were retrospectively reviewed. RESULTS: Ninety-one sepsis episodes were included in the study. Low albumin level ( U = 382.00, P = .006), renal failure (odds ratio [OR], 0.108 [95% CI, 0.015-0.783]; P = .025), and length of ICU stay ( U = 130.00, P < .001) were identified as risk factors of BSIs due to PIs. The probability of BSI during a sepsis episode was lower in CIPs with PIs with higher C -reactive protein levels ( U = 233.00, P < .001) and whose injury resulted from trauma or surgery (OR, 0.101 [95% CI, 0.016-0.626]; P = .014). The mortality was higher in CIPs with PI -induced BSIs (OR, 0.051 [95% CI, 0.008-0.309]; P = .001). CONCLUSIONS: Pressure injury -induced sepsis was associated with a high risk of 28 -day mortality. The findings suggest that CIPs with PI are at increased risk of BSIs if they have low albumin levels, renal -failure, and prolonged ICU stay during sepsis episodes.