Person: YALÇIN, EBRU
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YALÇIN
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EBRU
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Publication Evaluation of serum and tissue magnesium, vascular endothelial growth factor, and osteopontin levels in dogs with mammary tumors with/without pulmonary metastases and in healthy dogs(Polish Society Magnesium Research, 2021-01-01) Ucmak, Zeynep Gunay; Koenhemsi, Lora; Ucmak, Melih; ; Gonul, Remzi; Yalcin, Ebru; YALÇIN, EBRU; Ates, Atilla; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Biyokimya Anabilim Dalı.; 0000-0003-2530-1291; 0000-0002-4979-170X; 0000-0002-8688-127X; 0000-0002-9013-930X; D-3017-2019; AAG-7917-2020; B-6201-2015; B-2891-2015; ACP-9956-2022Mammary tumors in female dogs are usually malignant and tend to metastasize to distant organs, especially to regional lymph nodes and lungs. Radiography is the standard diagnostic method to detect pulmonary metastases in these animals. Magnesium (Mg). vascular endothelial growth factor (VEGF), and osteopontin (OPN) levels have been used in recent studies to make prognoses of human breast cancer. To the best of our knowledge, however, there are not many studies that have been performed on this subject, and there is no study on animals in which the three indicators are scrutinized together. The aim of this present study is to evaluate Mg, VEGF, and OPN levels in healthy dogs and in dogs with mammary tumors with/without pulmonary metastases, and to investigate the alterations of these parameters in the serum and tissue samples of dogs with mammary tumors in connection with the histological tumor type and tumor grade. Mammary tumor groups were designed according to the presence of pulmonary metastasis in radiography; group MI consists of 20 dogs with metastatic mammary ttunors to the lung, and group MO consists of 20 dogs with nonmetastatic mammary tumors. Ten clinically healthy dogs composed group H. The dogs represented different breeds and ages. Three-view thoracic radiographs were taken to determine any metastasis in lungs by digital radiography. Magnesium, VEGF, and OPN were determined in the mammary gland samples and blood serum of 40 dogs with malignant mammary tumors and in 10 healthy dogs. The magnesium levels were measured by atomic absorption spectrophotometry, both in the tissue and serum samples. Also, the tissue and serum VEGF and OPN levels were determined by ELISA with commercially available kits. The tissue Mg levels in the MO group were significantly (P<0.05) higher than in group H. However, the serum VEGF level was significantly associated with a tumor type. Additionally, the serum OPN levels exhibited a tendency to be higher in dogs with mammary tumors with pulmonary metastases, grade 3, and eaminosarcoma. It is concluded that Mg, VEGF, and OPN could have practical use for diagnosing and understanding the pathophysiology of CMT.Publication Identification of serum proteins in dogs naturally infected with Anaplasma phagocytophilum and Borrelia burgdorferi: A pilot study(Hellenic Veterinary Medical Soc, 2021-10-01) Martinez, L. F.; Escribano, D.; Schanilec, P.; Martinez-Subiela, S.; Tvarijonaviciute, A.; Ceron, J. J.; Yilmaz, Z.; Kocatürk, M.; Levent, P.; Sarıl, A.; SARIL, AHMET; Cihan, H.; Yilmaz, Zeki; YILMAZ, ZEKİ; Yalcin, E.; YALÇIN, EBRU; Bursa Uludağ Üniversitesi/Veteriner Fakültesi; 0000-0001-9836-0749; 0000-0002-6697-6079; ; ACP-9956-2022; A-9637-2008; ACP-9956-2022Serum proteomic analysis would aid in better understanding the pathophysiology of several diseases. The aim of this study was to identify the serum proteomes of dogs with anaplasmosis and Lyme disease using a pro-teomic approach. Diseases were diagnosed by a commercial rapid in-clinic ELISA. Borrelia antibodies were evaluated by IFAT. Four groups were designated: symptomatic dogs with anaplasmosis (n=5), dogs with Lyme disease (n=5), dual-positive dogs (n=5), and healthy control dogs (n=5). Serum samples were collected before treatment. Two-dimen-sional electrophoresis of pooled samples in each group were run in triplicate. Ten out of 57 differentially expressed spots between groups were evaluated for identification by mass spectrometry. Compared to those of controls, levels of vitamin D-binding protein (VDBP), glycoprotein-9 (GP9) and kininogen-1 (KGN-1) decreased, while haptoglobin (Hp) and immunoglobulin (Ig) heavy chain levels increased in dual infection group. Serum apolipoprotein-A1 (Apo-A1) levels decreased in dogs with anaplasmosis, Lyme disease and dual in-fections compared to those in control dogs. Serum clusterin levels decreased in dogs with anaplasmosis but were not differentially expressed in dogs with Lyme disease or dogs with dual infections compared to those in control dogs. Calpain-3 decreased in dogs with anaplasmosis and Lyme disease. This study showed that many protein levels might be changed in dogs with naturally acquired anaplasmosis and Lyme disease. Understanding the role of these proteins in different biological processes can provide information of interest for diagnostic and therapeutic approaches for these clinical conditions.Publication Changes in choline and cholinesterase in saliva of dogs with parvovirus infection(Elsevier, 2021-01-01) Kocatürk, Meriç; Tecles, Fernando; Yalçın, Ebru; Cihan, Hüseyin; Tural, Merve; Levent, Pınar; Cansev, Mehmet; Ceron, Jose J.; Yılmaz, Zeki; KOCATÜRK, MERİÇ; YALÇIN, EBRU; CİHAN, HÜSEYİN; Tural, Merve; Levent, Pınar; CANSEV, MEHMET; YILMAZ, ZEKİ; Bursa Uludağ Üniversitesi/Veteriner Fakültesi/İç Hastalıkları Anabilim Dalı.; Bursa Uludağ Üniversitesi/Tıp Fakültesi/Farmakoloji Anabilim Dalı.; 0000-0002-2849-1222; 0000-0001-6703-4908; 0000-0003-2918-5064; 0000-0001-9836-0749; M-9071-2019; GDR-9018-2022 ; V-5578-2017; ACP-9956-2022; A-9637-2008; ABH-3742-2020; DDR-1481-2022This study investigated the changes in choline (Ch) and butyrylcholinesterase (BChE) in saliva in canine parvovirosis (CP) as a model of sepsis, and their correlations with these analytes in serum and with other markers of inflammation such as white blood cell count (WBC) and serum C-reactive protein (CRP). A total of 30 dogs with CP were sampled for saliva and serum at presentation, and 10 healthy puppies were also sampled as controls. Salivary Ch was higher in dogs with CP (P < 0.001) showing a positive correlation with CRP, whereas no differences were observed in salivary BChE. This is the first report in which Ch is measured in saliva of dogs and based in the results of this study, salivary Ch could be potentially used as biomarker of the severity of CP.Publication Serum leptin and ghrelin levels and their relationship with serum cortisol,thyroid hormones, lipids, homocysteine and folic acid in dogs with compulsive tail chasing(Cabi Publishing-c A B Int, 2017-01-01) Yalçın, Ebru; Yılmaz, Zeki; Özarda, Yeşim; Denenberg, S; YALÇIN, EBRU; YILMAZ, ZEKİ; ÖZARDA, YEŞİM; Uludağ Üniversitesi/Veteriner Fakültesi/Dahiliye Bölümü; Denenberg, S; 0000-0001-9836-0749; 0000-0002-6697-6079; AAL-8873-2021; ACP-9956-2022; A-9637-2008Publication Effects of multimodal environmental modification in crystal-related feline lower urinary tract diseases(Arquivo Brasileiro Medicina Veterinaria Zootecnia, 2023-07-01) Kurum, Hilal; Yalçın, Ebru; YALÇIN, EBRU; Bursa Uludağ Üniversitesi/Veteriner Fakültesi; ACP-9956-2022This study aims to analyze the effects of multimodal environmental modification (MEMO) of cats with recurrence of lower urinary tract signs (LUTS). Treatment of FLUTD included pharmacological treatment, dietary management, and multimodal environmental modification approaches. Twenty client-owned indoor-housed cats with recurrence of lower urinary tract signs had been covered in this observation. Diagnosis of lower urinary tract was made primarily based on the cat's clinical signs, results of laboratory parameters, urinalysis and ultrasonographic examination. Cats were divided into two groups as cefovecin (8 mg/kg sc, single time use) + meloxicam (0.1mg/kg q24h, 3 days) + dry food including l-tryptophan and milk protein hydrolysate to dissolve struvite stones (Group 1) and cefovecin + meloxicam + dry food including l-tryptophan and milk protein hydrolysate to dissolve struvite stones + multimodal environmental modification (Group 2). Clinical and urinary parameters are scored as 0, 1, 2, 3 or 4 points on initial, third, seventh days. Scores of clinical parameters were significantly different between (p<0.05) group 2 and group 1 on the third and seventh days and scores of urinary parameters are significantly different between (p<0.05) group 2 than group 1 on the seventh day. Clients who were contacted after 1 year reported that they did not see any clinical signs of urinary tract diseases.