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An unusual case of adult-onset multi-systemic langerhans cell histiocytosis with perianal and incident thyroid involvement

dc.contributor.authorGül, Özen Öz
dc.contributor.authorŞişman, Pınar
dc.contributor.authorCander, Soner
dc.contributor.authorGözden, Erdem
dc.contributor.authorKurt, Meral
dc.contributor.authorSaraydaroğlu, Özlem
dc.contributor.authorKırdak, Turkay
dc.contributor.authorErsoy, Canan
dc.contributor.authorErtürk, Erdinç
dc.contributor.buuauthorÖZ GÜL, ÖZEN
dc.contributor.buuauthorŞişman, Pınar
dc.contributor.buuauthorKURT, MERAL
dc.contributor.buuauthorCANDER, SONER
dc.contributor.buuauthorGözden, Erdem
dc.contributor.buuauthorSARAYDAROĞLU, ÖZLEM
dc.contributor.buuauthorKırdak, Turkay
dc.contributor.buuauthorERSOY, CANAN
dc.contributor.buuauthorERTÜRK, ERDİNÇ
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Endokrinoloji ve Metabolizma Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Hematoloji Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Radyasyon Onkolojisi Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Cerrahi Anabilim Dalı.
dc.contributor.researcheridAAI-1005-2021
dc.contributor.researcheridDUS-9872-2022
dc.contributor.researcheridHUR-0563-2023
dc.contributor.researcheridEWL-5375-2022
dc.contributor.researcheridAAA-3961-2020
dc.contributor.researcheridAAH-9701-2021
dc.contributor.researcheridCZX-7145-2022
dc.contributor.researcheridAAH-8861-2021
dc.contributor.researcheridAAJ-6536-2021
dc.date.accessioned2024-10-04T11:29:25Z
dc.date.available2024-10-04T11:29:25Z
dc.date.issued2017-02-01
dc.description.abstractLangerhans cell histiocytosis (LCH) is a rare sporadic disease characterized by histiocytic neoplastic infiltration of various organ systems and a wide spectrum of clinical manifestations, ranging from benign and self-limiting to lethal. Herein, we report a rare case of adult-onset multi-systemic LCH in a 36-year-old male patient with an initial perianal presentation and incidental finding of subsequent thyroid gland involvement in the follow-up period. The patient with a history of perianal LCH treated with surgical excision and local radiotherapy was referred to our Endocrinology Department upon detection of hypermetabolic nodular lesions in the left lateral lobe of thyroid gland on positron emission tomography-computed tomography (PET/CT)scan in the nineth month of follow-up. Current evaluation revealed euthyroid status, a hypoechoic solid lesion of 13 x 9 mm in size with irregular borders in the left thyroid lobe on thyroid USG and cytologic assessment of thyroid nodule. The patient was diagnosed with suspected, oncocytic lesion, Hashimoto thyroiditis or LCH. The patient underwent total thyroidectomy and pathological assessment confirmed the diagnosis of Langerhans cell histiocytosis. Assessments in the sixth month of postoperative follow-up revealed euthyroid status with no thyroid tissue remnants or pathological lymph node on thyroid USG. In view of the multifocal lesions indicating multi-system disease, a systemic chemotherapy protocol with combination of prednisone (PRED) and vinblastine (VBL) has been planned by the hematology department.
dc.identifier.doi10.1530/EDM-16-0087
dc.identifier.eissn2052-0573
dc.identifier.urihttps://doi.org/10.1530/EDM-16-0087
dc.identifier.urihttps://edm.bioscientifica.com/view/journals/edm/2017/1/EDM16-0087.xml
dc.identifier.urihttps://hdl.handle.net/11452/45879
dc.identifier.wos000396742100001
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherBioscientifica Ltd
dc.relation.journalEndocrinology Diabetes and Metabolism Case Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDiagnosis
dc.subjectEndocrinology & metabolism
dc.titleAn unusual case of adult-onset multi-systemic langerhans cell histiocytosis with perianal and incident thyroid involvement
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery4ebb27f5-06de-45b8-8773-ea3452507df3

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