Publication: (E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation
dc.contributor.author | Rabha, Younis | |
dc.contributor.author | Han-Shen, Tae | |
dc.contributor.author | Ortells, Marcelo O. | |
dc.contributor.author | Arias, Hugo R. | |
dc.contributor.author | Bağdaş, Deniz | |
dc.contributor.author | Gül, Zülfiye | |
dc.contributor.buuauthor | Sevdar, Gülce | |
dc.contributor.buuauthor | Cavun, Sinan | |
dc.contributor.buuauthor | Gürün, Mine Sibel | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Sinir Bilimleri ve Nöroloji | |
dc.contributor.orcid | 0000-0003-0307-3486 | |
dc.contributor.orcid | 0000-0001-5050-095X | |
dc.contributor.researcherid | JCN-7924-2023 | |
dc.contributor.researcherid | AAC-9702-2019 | |
dc.contributor.researcherid | DVX-8040-2022 | |
dc.contributor.scopusid | 57226240379 | |
dc.contributor.scopusid | 6507468595 | |
dc.contributor.scopusid | 55664349700 | |
dc.date.accessioned | 2024-02-20T07:35:06Z | |
dc.date.available | 2024-02-20T07:35:06Z | |
dc.date.issued | 2021-07-27 | |
dc.description.abstract | Clinical intervention of pain is often accompanied by changes in affective behaviors, so both assays of affective and sensorial aspects of nociception play an important role in the development of novel analgesics. Although positive allosteric modulation (PAM) of alpha 7 nicotinic acetylcholine receptors (nAChRs) has been recognized as a novel approach for the relief of sensorial aspects of pain, their effects on affective components of pain remain unclear. Therefore, we investigated whether PAM-4, a highly selective alpha 7-nAChR PAM, attenuates inflammatory and neuropathic pain, as well as the concomitant depressive/anxiety comorbidities. The anti-nociceptive activity of PAM-4 was assessed in mice using the formalin test and chronic constriction injury (CCI)-induced neuropathic pain model. The anxiolytic- and antidepressant-like activity of PAM-4 was evaluated using the marble burying test and forced swimming test. Acute systemic administration of PAM-4 dose-dependently reversed formalin-induced paw licking behavior and CCI-induced mechanical allodynia without development of any motor impairment. PAM-4 reversed the decreased swimming time and number of buried marbles in CCI-treated mice, suggesting that this ligand attenuates chronic pain-induced depression-like behavior and anxiogenic-like effects. The effects of PAM-4 were inhibited by the alpha 7-selective antagonist methyllycaconitine, indicating molecular mechanism mediated by alpha 7-nAChRs. Indeed, electrophysiological recordings showed the PAM-4 enhances human alpha 7 nAChRs with higher potency and efficacy compared to rat alpha 7 nAChRs. These findings suggest that PAM-4 reduces both sensorial and affective behaviors induced by chronic pain in mice by alpha 7-nAChR potentiation. PAM-4 deserves further investigations for the management of chronic painful conditions with comorbidities. | en_US |
dc.description.sponsorship | OVPR Pilot/Seed Grant (Oklahoma State University Center for Health Sciences) | en_US |
dc.identifier.citation | Deniz, B. vd. (2021). "(E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation". Neurological Research, 43(12), 1056-1068. | en_US |
dc.identifier.doi | https://doi.org/10.1080/01616412.2021.1949684 | |
dc.identifier.endpage | 1068 | tr_TR |
dc.identifier.issn | 0161-6412 | |
dc.identifier.issn | 1743-1328 | |
dc.identifier.issue | 12 | tr_TR |
dc.identifier.pubmed | 34281483 | tr_TR |
dc.identifier.scopus | 2-s2.0-85110975018 | tr_TR |
dc.identifier.startpage | 1056 | tr_TR |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.1080/01616412.2021.1949684 | |
dc.identifier.uri | https://hdl.handle.net/11452/39859 | |
dc.identifier.volume | 43 | tr_TR |
dc.identifier.wos | 000675131800001 | |
dc.indexed.pubmed | PubMed | en_US |
dc.indexed.scopus | Scopus | en_US |
dc.indexed.wos | SCIE | en_US |
dc.language.iso | en | en_US |
dc.publisher | Taylor and Francis | en_US |
dc.relation.collaboration | Yurt içi | tr_TR |
dc.relation.collaboration | Yurt dışı | tr_TR |
dc.relation.collaboration | Sanayi | tr_TR |
dc.relation.journal | Neurological Research | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | tr_TR |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Alpha 7 nicotinic acetylcholine receptors | en_US |
dc.subject | Positive allosteric modulator | en_US |
dc.subject | Pam-4 | en_US |
dc.subject | Formalin | en_US |
dc.subject | Chronic constriction injury | en_US |
dc.subject | Neuropathic pain | en_US |
dc.subject | Electrophysiology | en_US |
dc.subject | Cigarette-smoking | en_US |
dc.subject | Negative affect | en_US |
dc.subject | Screening-test | en_US |
dc.subject | Animal-models | en_US |
dc.subject | Mouse models | en_US |
dc.subject | Depression | en_US |
dc.subject | Agonist | en_US |
dc.subject | 3-Furan2-yl-n-p-tolyl-acrylamide | en_US |
dc.subject | Anxiety | en_US |
dc.subject | Neurosciences & neurology | en_US |
dc.subject.emtree | Acetylcholine | en_US |
dc.subject.emtree | Bicarbonate | en_US |
dc.subject.emtree | Bungarotoxin receptor | en_US |
dc.subject.emtree | Complementary rna | en_US |
dc.subject.emtree | Distilled water | en_US |
dc.subject.emtree | Formaldehyde | en_US |
dc.subject.emtree | Fresh water | en_US |
dc.subject.emtree | Furan derivative | en_US |
dc.subject.emtree | Gentamicin | en_US |
dc.subject.emtree | Hydrogen | en_US |
dc.subject.emtree | Ketamine | en_US |
dc.subject.emtree | Methyllycaconitine | en_US |
dc.subject.emtree | Penicillin derivative | en_US |
dc.subject.emtree | Ricinomacrogol | en_US |
dc.subject.emtree | Streptomycin | en_US |
dc.subject.emtree | Water | en_US |
dc.subject.emtree | Xylazine | en_US |
dc.subject.emtree | Acrylamide derivative | en_US |
dc.subject.emtree | Analgesic agent | en_US |
dc.subject.emtree | Bungarotoxin receptor | en_US |
dc.subject.emtree | N-phenylacrylamide | en_US |
dc.subject.emtree | Mino acid sequence | en_US |
dc.subject.emtree | Analgesic activity | en_US |
dc.subject.emtree | Anesthesia | en_US |
dc.subject.emtree | Animal experiment | en_US |
dc.subject.emtree | Animal model | en_US |
dc.subject.emtree | Animal tissue | en_US |
dc.subject.emtree | Antidepressant activity | en_US |
dc.subject.emtree | Anxiety | en_US |
dc.subject.emtree | Article | en_US |
dc.subject.emtree | Behavior | en_US |
dc.subject.emtree | Blood brain barrier | en_US |
dc.subject.emtree | Chronic constriction injury | en_US |
dc.subject.emtree | Chronic pain | en_US |
dc.subject.emtree | Comorbidity | en_US |
dc.subject.emtree | Controlled study | en_US |
dc.subject.emtree | Depression | en_US |
dc.subject.emtree | Electrophysiology | en_US |
dc.subject.emtree | Fetal bovine serum | en_US |
dc.subject.emtree | Forced swim test | en_US |
dc.subject.emtree | Hypersensitivity | en_US |
dc.subject.emtree | İncubation time | en_US |
dc.subject.emtree | Latent period | en_US |
dc.subject.emtree | Light dark cycle | en_US |
dc.subject.emtree | Lipophilicity | en_US |
dc.subject.emtree | Locomotion | en_US |
dc.subject.emtree | Male | en_US |
dc.subject.emtree | Marble burying test | en_US |
dc.subject.emtree | Motor dysfunction | en_US |
dc.subject.emtree | Mouse | en_US |
dc.subject.emtree | Neuropathic pain | en_US |
dc.subject.emtree | Nociception | en_US |
dc.subject.emtree | Nonhuman | en_US |
dc.subject.emtree | Oocyte | en_US |
dc.subject.emtree | Post hoc analysis | en_US |
dc.subject.emtree | Rigidity | en_US |
dc.subject.emtree | Sciatic nerve | en_US |
dc.subject.emtree | Stopwatch | en_US |
dc.subject.emtree | Tranquilizing activity | en_US |
dc.subject.emtree | Voltage clamp technique | en_US |
dc.subject.emtree | Von frey test | en_US |
dc.subject.emtree | Animal | en_US |
dc.subject.emtree | Animal behavior | en_US |
dc.subject.emtree | Bagg albino mouse | en_US |
dc.subject.emtree | Drug effect | en_US |
dc.subject.emtree | Metabolism | en_US |
dc.subject.emtree | Neuralgia | en_US |
dc.subject.emtree | Nociception | en_US |
dc.subject.emtree | Psychology | en_US |
dc.subject.mesh | Acrylamides | en_US |
dc.subject.mesh | Alpha7 nicotinic acetylcholine receptor | en_US |
dc.subject.mesh | Analgesics | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Anxiety | en_US |
dc.subject.mesh | Behavior, animal | en_US |
dc.subject.mesh | Depression | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Mice | en_US |
dc.subject.mesh | Mice, inbred balb c | en_US |
dc.subject.mesh | Neuralgia | en_US |
dc.subject.mesh | Nociception | en_US |
dc.subject.scopus | Inflammation; Methyllycaconitine; 3-(2,4-Dimethoxybenzylidene)Anabaseine | en_US |
dc.subject.wos | Clinical neurology | en_US |
dc.subject.wos | Neurosciences | en_US |
dc.title | (E)-3-furan-2-yl-N-phenylacrylamide (PAM-4) decreases nociception and emotional manifestations of neuropathic pain in mice by α7 nicotinic acetylcholine receptor potentiation | en_US |
dc.type | Article | en_US |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/Sinir Bilimleri ve Nöroloji |
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