Publication:
Expression of the ionotropic glutamate receptors on neuronostatin neurons in the periventricular nucleus of the hypothalamus

dc.contributor.authorKocoğlu, S. Serter
dc.contributor.buuauthorÇakir, Cihan
dc.contributor.buuauthorÇAKIR, CİHAN
dc.contributor.buuauthorEyigör, Özhan
dc.contributor.buuauthorMİNBAY, FATMA ZEHRA
dc.contributor.buuauthorEYİGÖR, ÖZHAN
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı.
dc.contributor.orcid0000-0002-8332-7353
dc.contributor.orcid0000-0003-3463-7483
dc.contributor.researcheridABC-1475-2020
dc.contributor.researcheridABE-5128-2020
dc.contributor.researcheridAAH-5249-2021
dc.contributor.researcheridABQ-8779-2022
dc.date.accessioned2024-11-06T05:58:39Z
dc.date.available2024-11-06T05:58:39Z
dc.date.issued2022-01-01
dc.description.abstractBackground: Neuronostatin, a newly identified peptide, is accepted as an anorex- igenic peptide since it suppresses food intake when given intracerebroventricularly. Although the effect mechanisms of neuronostatin have been shown in different studies, there are no reports in the literature describing the mechanisms controlling neuronostatin neurons. In this study, we aimed to determine the presence of the ionotropic glutamate receptor subunits (iGluRs) in neuronostatin neurons in the periventricular nucleus of the hypothalamus. Materials and methods: The presence of glutamate receptors in neuronostatin neurons was investigated by dual immunohistochemistry. Immunohistochemistry was performed on 40 mu m thick coronal brain sections with antibodies against AMPA (GluA1-4), kainate (GluK1/2/3, and GluK5), and NMDA (GluN1 and GluN2A) receptor subunits. Results: The results showed that the neuronostatin neurons expressed most of the NMDA and non-NMDA receptor subunits. The neuronostatin neurons in the anterior hypothalamic periventricular nucleus were particularly immunopositive for GluA1, GluA4, GluK1/2/3, GluK5 and GluN1 antibodies. No expression was observed for GluA2, GluA3 and GluN2A antibodies. Conclusions: For the first time in the literature, our study demonstrated that the neuronostatin neurons express glutamate receptor subunits which may form homomeric or heteromeric functional receptor complexes. Taken together, these results suggest that multiple subunits of iGluRs are responsible for glutamate transmission on neuronostatin neurons in the anterior hypothalamic periventricular nucleus.
dc.identifier.doi10.5603/FM.a2020.0145
dc.identifier.endpage19
dc.identifier.issn0015-5659
dc.identifier.issue1
dc.identifier.startpage13
dc.identifier.urihttps://doi.org/10.5603/FM.a2020.0145
dc.identifier.urihttps://hdl.handle.net/11452/47466
dc.identifier.volume81
dc.identifier.wos000768747000001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherVia Medica
dc.relation.journalFolia Morphologica
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectMessenger-rnas
dc.subjectKainate
dc.subjectSubunits
dc.subjectLocalization
dc.subjectSomatostatin
dc.subjectModulation
dc.subjectMechanism
dc.subjectLight
dc.subjectNeuronostatin
dc.subjectGlutamate
dc.subjectNmda
dc.subjectKainate
dc.subjectAmpa
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectAnatomy & morphology
dc.titleExpression of the ionotropic glutamate receptors on neuronostatin neurons in the periventricular nucleus of the hypothalamus
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationba820810-4653-4ae4-b4ff-511e9021ceca
relation.isAuthorOfPublicationf1bfa5b7-14d3-4734-a407-8300bea2fefe
relation.isAuthorOfPublication57503bab-1719-45f6-a0e0-df41bd5cd569
relation.isAuthorOfPublication.latestForDiscoveryba820810-4653-4ae4-b4ff-511e9021ceca

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