Publication:
The mediation of central cyclooxygenase and lipoxygenase pathways in orexin-induced cardiovascular effects

dc.contributor.authorAltınbaş, Burçin
dc.contributor.authorGüvenç-Bayram, Gökçen
dc.contributor.authorYalçın, Murat
dc.contributor.buuauthorYALÇIN, MURAT
dc.contributor.buuauthorAltınbaş, Burçin
dc.contributor.buuauthorGüvenç-Bayram, Gökçen
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi/Fizyoloji Anabilim Dalı
dc.contributor.orcid0000-0002-1413-3651
dc.contributor.orcid0000-0002-5600-8162
dc.contributor.orcid0000-0002-9534-736X
dc.contributor.researcheridIYS-2646-2023
dc.contributor.researcheridAAR-6815-2021
dc.contributor.researcheridAAG-6956-2021
dc.date.accessioned2024-06-04T08:07:10Z
dc.date.available2024-06-04T08:07:10Z
dc.date.issued2021-03-01
dc.description.abstractPreviously it was reported that central orexin (OX) and arachidonic acid (AA) signaling pathways played an active role in the control of the cardiovascular system. It was also reported that they have exhibited their cardiovascular control role by using similar central or peripheral mechanisms. However, there has been no study demonstrating the interaction between OX and AA signaling pathways in terms of cardiovascular control. The current study was designed to investigate the possible mediation of the central cyclooxygenase (COX) and lipoxygenase (LOX) pathways in OX-induced cardiovascular effects in the rats.Intracerebroventricular injection of OX increased blood pressure and heart rate in a dose-dependent manner in normotensive male Sprague Dawley rats. Moreover, the microdialysis study revealed that intracerebroventricular injected OX caused a time-dependent increase in the extracellular total prostaglandin concentrations in the posterior hypothalamus. Interestingly, central pretreatment with a non-selective COX inhibitor, ibuprofen, or a non-selective LOX inhibitor, nordihydroguaiaretic acid, partially reversed pressor and tachycardic cardiovascular responses evoked by central administration of OX.In summary, our findings show that the central treatment with OX causes pressor and tachycardic cardiovascular responses along with an increase in posterior hypothalamic extracellular total prostaglandin concentrations. Furthermore, our results also demonstrate that central COX and LOX pathways mediate, at least in part, centrally administered OX-evoked pressor and tachycardic responses, as well.
dc.identifier.doi10.1016/j.brainres.2020.147239
dc.identifier.issn0006-8993
dc.identifier.issn1872-6240
dc.identifier.pubmed33412148
dc.identifier.urihttps://doi.org/10.1016/j.brainres.2020.147239
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S0006899320305977
dc.identifier.urihttps://hdl.handle.net/11452/41712
dc.identifier.volume1754
dc.identifier.wos000614110700003
dc.indexed.pubmedPubMed
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherElsevier
dc.relation.journalBrain Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak214O728
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectRostral ventrolateral medulla
dc.subjectPhospholipase a(2) activator
dc.subjectCentral histaminergic system
dc.subjectArachidonic-acid
dc.subjectArterial-pressure
dc.subjectInjected melittin
dc.subjectHypotensive rats
dc.subjectThromboxane a(2)
dc.subjectHeart-rate
dc.subjectNeurons
dc.subjectOrexin
dc.subjectCylooygenase and lipoxygenase pathways
dc.subjectCardiovascular parameters
dc.subjectIntracerebroventricular
dc.subjectMicrodialysis
dc.subjectPosterior hypothalamus
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectNeurosciences
dc.subjectNeurosciences & neurology
dc.titleThe mediation of central cyclooxygenase and lipoxygenase pathways in orexin-induced cardiovascular effects
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication90abe2d4-19a5-42d8-b921-d41cf6e684c8
relation.isAuthorOfPublication.latestForDiscovery90abe2d4-19a5-42d8-b921-d41cf6e684c8

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