Publication:
Anti-HDV IgM as a marker of disease activity in hepatitis delta

dc.contributor.authorWranke, Anika
dc.contributor.authorHeidrich, Benjamin
dc.contributor.authorErnst, Stefanie
dc.contributor.authorSerrano, Beatriz Calle
dc.contributor.authorCaruntu, Florin Alexandru
dc.contributor.authorCurescu, Manuela Gabriela
dc.contributor.authorYalcin, Kendal
dc.contributor.authorGürel, Selim
dc.contributor.authorZeuzem, Stefan
dc.contributor.authorErhardt, Andreas
dc.contributor.authorLueth, Stefan
dc.contributor.authorPapatheodoridis, George V.
dc.contributor.authorBremer, Birgit
dc.contributor.authorStift, Judith
dc.contributor.authorGrabowski, Jan
dc.contributor.authorKirschner, Janina
dc.contributor.authorPort, Kerstin
dc.contributor.authorCornberg, Markus
dc.contributor.authorFalk, Christine S.
dc.contributor.authorDienes, Hans-Peter
dc.contributor.authorHardtke, Svenja
dc.contributor.authorManns, Michael P.
dc.contributor.authorYurdaydin, Cihan
dc.contributor.authorWedemeyer, Heiner
dc.contributor.authorHIDIT-2 Study Grp
dc.contributor.buuauthorGÜREL, SELİM
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi.
dc.contributor.researcheridHLH-8209-2023
dc.date.accessioned2024-08-15T10:15:33Z
dc.date.available2024-08-15T10:15:33Z
dc.date.issued2014-07-29
dc.description.abstractBackground: Hepatitis delta frequently leads to liver cirrhosis and hepatic decompensation. As treatment options are limited, there is a need for biomarkers to determine disease activity and to predict the risk of disease progression. We hypothesized that anti-HDV IgM could represent such a marker.Methods: Samples of 120 HDV-infected patients recruited in an international multicenter treatment trial (HIDIT-2) were studied. Anti-HDV IgM testing was performed using ETI-DELTA-IGMK-2-assay (DiaSorin). In addition, fifty cytokines, chemokines and angiogenetic factors were measured using multiplex technology (Bio-Plex System). A second independent cohort of 78 patients was studied for the development of liver-related clinical endpoints (decompensation, HCC, liver transplantation or death; median follow up of 3.0 years, range 0.6-12).Results: Anti-HDV IgM serum levels were negative in 18 (15%), low (OD<0.5) in 76 (63%), and high in 26 (22%) patients of the HIDIT-2 cohort. Anti-HDV IgM were significantly associated with histological inflammatory (p<0.01) and biochemical disease activity (ALT, AST p<0.01). HDV replication was independent from anti-HDV IgM, however, low HBV-DNA levels were observed in groups with higher anti-HDV IgM levels (p<0.01). While high IP-10 (CXCL10) levels were seen in greater groups of anti-HDV IgM levels, various other antiviral cytokines were negatively associated with anti-HDV IgM. Associations between anti-HDV IgM and ALT, AST, HBV-DNA were confirmed in the independent cohort. Clinical endpoints occurred in 26 anti-HDV IgM positive patients (39%) but in only one anti-HDV IgM negative individual (9%; p = 0.05).Conclusions: Serum anti-HDV IgM is a robust, easy-to-apply and relatively cheap marker to determine disease activity in hepatitis delta which has prognostic implications. High anti-HDV IgM levels may indicate an activated interferon system but exhausted antiviral immunity.
dc.description.sponsorshipFederal Ministry of Education & Research (BMBF)
dc.description.sponsorshipHannover Medical School, Germany (IFB-Tx) 01E00802
dc.description.sponsorshipRoche Holding
dc.description.sponsorshipGilead Sciences
dc.identifier.doi10.1371/journal.pone.0101002
dc.identifier.issn1932-6203
dc.identifier.issue7
dc.identifier.urihttps://doi.org/10.1371/journal.pone.0101002
dc.identifier.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0101002
dc.identifier.urihttps://hdl.handle.net/11452/44057
dc.identifier.volume9
dc.identifier.wos000341307600005
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherPublic Library Science
dc.relation.journalPlos One
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectB-virus
dc.subjectLiver-transplantation
dc.subjectInterferon
dc.subjectInfection
dc.subjectChallenges
dc.subjectAntibodies
dc.subjectProfiles
dc.subjectTherapy
dc.subjectCells
dc.subjectScience & technology - other topics
dc.titleAnti-HDV IgM as a marker of disease activity in hepatitis delta
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationd7a9ea11-69fc-4122-a365-8fb2123512e6
relation.isAuthorOfPublication.latestForDiscoveryd7a9ea11-69fc-4122-a365-8fb2123512e6

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