Publication: Prognostic significance of estrogen receptor, progesterone receptor, her2/neu, ki-67, and nm23 expression in patients with invasive breast cancer
dc.contributor.author | Ölmez, F. | |
dc.contributor.buuauthor | Çubukçu, E. | |
dc.contributor.buuauthor | ÇUBUKÇU, ERDEM | |
dc.contributor.buuauthor | DELİGÖNÜL, ADEM | |
dc.contributor.buuauthor | Kanat, O. | |
dc.contributor.buuauthor | Ölmez, O. Fatih | |
dc.contributor.buuauthor | Kabul, S. | |
dc.contributor.buuauthor | KABUL, SELVA | |
dc.contributor.buuauthor | Canhoroz, M. | |
dc.contributor.buuauthor | Avcı, N. | |
dc.contributor.buuauthor | Deligönül, A. | |
dc.contributor.buuauthor | Hartavi, M. | |
dc.contributor.buuauthor | Çubukçu, S. | |
dc.contributor.buuauthor | ÇUBUKÇU, SİNEM | |
dc.contributor.buuauthor | Kurt, E. | |
dc.contributor.buuauthor | Evrensel, T. | |
dc.contributor.buuauthor | EVRENSEL, TÜRKKAN | |
dc.contributor.buuauthor | Gökgöz, S. | |
dc.contributor.buuauthor | GÖKGÖZ, MUSTAFA ŞEHSUVAR | |
dc.contributor.buuauthor | Manavoğlu, O. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Onkoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı. | |
dc.contributor.researcherid | AAJ-1027-2021 | |
dc.date.accessioned | 2024-08-15T13:26:43Z | |
dc.date.available | 2024-08-15T13:26:43Z | |
dc.date.issued | 2013-04-01 | |
dc.description.abstract | Purpose: To determine the prognostic significance of estrogen receptor (ER), progesterone receptor (PR), HER2/neu, Ki-67, and nm23 immunohistochemical expression with respect to progression free survival (PFS) and overall survival (OS) in Turkish patients with invasive breast cancer (IBC).Methods: Patients with IBC (n = 81; mean age = 51.9 +/- 11.1 years) were prospectively enrolled at the Department of Oncology, Uludag University Medical Center, Bursa, Turkey. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections.Results: We did not find any significant association between immunohistochemical expression of ER, PR, HER2/neu, Ki-67, and nm23 and the baseline characteristics of IBC patients. The median patient PFS was 30 months (range 22-45), and the median OS was 32 months (range 23-46). Stratification of the patient population according to nm23 immunohistochemical expression revealed a statistically significant difference in terms of both OS (p < 0.05) and DFS (p < 0.05). Multivariate Cox regression analysis indicated that tumor grade, axillary lymph node status, and nm23 immunohistochemical expression were the 3 main independent prognostic factors for PFS and OS in IBC patients.Conclusion: Reduced nm23 immunohistochemical expression is an independent negative prognostic factor for OS and PFS. Patients with negative nm23 expression may require a more intensive follow-up. | |
dc.identifier.endpage | 365 | |
dc.identifier.issn | 1107-0625 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 359 | |
dc.identifier.uri | https://hdl.handle.net/11452/44086 | |
dc.identifier.volume | 18 | |
dc.identifier.wos | 000322750700008 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Imprimatur Publications | |
dc.relation.journal | Journal Of Buon | |
dc.relation.publicationcategory | Makale - Ulusal Hakemli Dergi | |
dc.subject | Lymph-node metastasis | |
dc.subject | Hormone-receptor | |
dc.subject | In-situ | |
dc.subject | Carcinoma | |
dc.subject | Suppressor | |
dc.subject | Biology | |
dc.subject | Protein | |
dc.subject | Immunohistochemistry | |
dc.subject | Invasive breast cancer | |
dc.subject | Nm23 | |
dc.subject | Prognosis | |
dc.subject | Survival | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Oncology | |
dc.title | Prognostic significance of estrogen receptor, progesterone receptor, her2/neu, ki-67, and nm23 expression in patients with invasive breast cancer | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | f971677f-09c5-4463-bf01-3c6341fbe5f7 | |
relation.isAuthorOfPublication | 76775155-c27b-4421-bb7b-b154db42aac3 | |
relation.isAuthorOfPublication | edfc19d5-ce9e-4fbd-8a24-07492003c264 | |
relation.isAuthorOfPublication | 375ef438-7ff8-4a42-97a4-74096fac117f | |
relation.isAuthorOfPublication | eceff514-6af7-4c3b-a146-b77546565a6c | |
relation.isAuthorOfPublication | 7b478372-ad3a-4f0a-a336-3ebde58856eb | |
relation.isAuthorOfPublication.latestForDiscovery | f971677f-09c5-4463-bf01-3c6341fbe5f7 |