Publication:
Prognostic significance of estrogen receptor, progesterone receptor, her2/neu, ki-67, and nm23 expression in patients with invasive breast cancer

dc.contributor.authorÖlmez, F.
dc.contributor.buuauthorÇubukçu, E.
dc.contributor.buuauthorÇUBUKÇU, ERDEM
dc.contributor.buuauthorDELİGÖNÜL, ADEM
dc.contributor.buuauthorKanat, O.
dc.contributor.buuauthorÖlmez, O. Fatih
dc.contributor.buuauthorKabul, S.
dc.contributor.buuauthorKABUL, SELVA
dc.contributor.buuauthorCanhoroz, M.
dc.contributor.buuauthorAvcı, N.
dc.contributor.buuauthorDeligönül, A.
dc.contributor.buuauthorHartavi, M.
dc.contributor.buuauthorÇubukçu, S.
dc.contributor.buuauthorÇUBUKÇU, SİNEM
dc.contributor.buuauthorKurt, E.
dc.contributor.buuauthorEvrensel, T.
dc.contributor.buuauthorEVRENSEL, TÜRKKAN
dc.contributor.buuauthorGökgöz, S.
dc.contributor.buuauthorGÖKGÖZ, MUSTAFA ŞEHSUVAR
dc.contributor.buuauthorManavoğlu, O.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Onkoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.
dc.contributor.researcheridAAJ-1027-2021
dc.date.accessioned2024-08-15T13:26:43Z
dc.date.available2024-08-15T13:26:43Z
dc.date.issued2013-04-01
dc.description.abstractPurpose: To determine the prognostic significance of estrogen receptor (ER), progesterone receptor (PR), HER2/neu, Ki-67, and nm23 immunohistochemical expression with respect to progression free survival (PFS) and overall survival (OS) in Turkish patients with invasive breast cancer (IBC).Methods: Patients with IBC (n = 81; mean age = 51.9 +/- 11.1 years) were prospectively enrolled at the Department of Oncology, Uludag University Medical Center, Bursa, Turkey. Immunohistochemistry was performed on formalin-fixed, paraffin-embedded tissue sections.Results: We did not find any significant association between immunohistochemical expression of ER, PR, HER2/neu, Ki-67, and nm23 and the baseline characteristics of IBC patients. The median patient PFS was 30 months (range 22-45), and the median OS was 32 months (range 23-46). Stratification of the patient population according to nm23 immunohistochemical expression revealed a statistically significant difference in terms of both OS (p < 0.05) and DFS (p < 0.05). Multivariate Cox regression analysis indicated that tumor grade, axillary lymph node status, and nm23 immunohistochemical expression were the 3 main independent prognostic factors for PFS and OS in IBC patients.Conclusion: Reduced nm23 immunohistochemical expression is an independent negative prognostic factor for OS and PFS. Patients with negative nm23 expression may require a more intensive follow-up.
dc.identifier.endpage365
dc.identifier.issn1107-0625
dc.identifier.issue2
dc.identifier.startpage359
dc.identifier.urihttps://hdl.handle.net/11452/44086
dc.identifier.volume18
dc.identifier.wos000322750700008
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherImprimatur Publications
dc.relation.journalJournal Of Buon
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi
dc.subjectLymph-node metastasis
dc.subjectHormone-receptor
dc.subjectIn-situ
dc.subjectCarcinoma
dc.subjectSuppressor
dc.subjectBiology
dc.subjectProtein
dc.subjectImmunohistochemistry
dc.subjectInvasive breast cancer
dc.subjectNm23
dc.subjectPrognosis
dc.subjectSurvival
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectOncology
dc.titlePrognostic significance of estrogen receptor, progesterone receptor, her2/neu, ki-67, and nm23 expression in patients with invasive breast cancer
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscoveryf971677f-09c5-4463-bf01-3c6341fbe5f7

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