Publication:
The regulatory effect of cabazitaxel on epithelial-mesenchymal transition in metastatic prostate cancer

dc.contributor.authorEskiler, Gamze Guney
dc.contributor.buuauthorERYILMAZ, IŞIL EZGİ
dc.contributor.buuauthorEGELİ, ÜNAL
dc.contributor.buuauthorÇEÇENER, GÜLŞAH
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.
dc.contributor.orcid0000-0002-2088-9914
dc.contributor.researcheridAAB-6011-2022
dc.date.accessioned2024-11-06T13:02:53Z
dc.date.available2024-11-06T13:02:53Z
dc.date.issued2023-01-01
dc.description.abstractIntroduction:Epithelial-mesenchymal transition (EMT) is a critical mechanism that promotes cancer cells to metastasis. Therefore, EMT regulation has become an important target in anticancer therapy approaches in recent years. However, in metastatic prostate cancer (PC), the EMT regulatory effect has not fully understood for cabazitaxel (Cbx), a third line taxane-based chemotherapeutic for metastatic castration-resistant PC.Aim:In this study, we investigated the antimetastatic and EMT-regulatory effects of Cbx on hormone-sensitive metastatic PC cells.Materials and Methods:The anticancer effects of Cbx were assessed by WST-1 and Annexin V analysis. The antimetastatic effect of Cbx was evaluated by wound healing and quantitative reverse transcription polymerase chain reaction through EMT-mesenchymal-to-epithelial transition (MET) markers as well as EMT-repressor microRNAs (miRNAs) in Cbx-treated LNCaP cells.Results:Our results showed that, in addition to its apoptotic and anti-migratory activities, Cbx exhibited the EMT-repressor effects through the prominent downregulation of matrix metalloproteinase-9 and Snail levels as EMT-promoting factors, and the significant upregulation of the certain miRNAs, including miR-205, miR-524, and miR-124, which play a role in EMT-repressing by targeting regulators of the EMT-associated genes.Conclusion:Although further evaluations are needed to improve the findings, we showed that, in addition to its classical taxane function, Cbx has a regulatory effect on EMT-MET cycling in hormone-sensitive metastatic PC.
dc.identifier.doi10.4103/jcrt.jcrt_364_21
dc.identifier.issn0973-1482
dc.identifier.issueSUPPL 1
dc.identifier.urihttps://doi.org/10.4103/jcrt.jcrt_364_21
dc.identifier.urihttps://hdl.handle.net/11452/47507
dc.identifier.volume19
dc.identifier.wos001267508000032
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.bapBUAP[T]-2015/4
dc.relation.journalJournal Of Cancer Research And Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectTgf-beta
dc.subjectTherapy
dc.subjectGrowth
dc.subjectCells
dc.subjectProliferation
dc.subjectExpression
dc.subjectTgf-beta-1
dc.subjectResistance
dc.subjectDocetaxel
dc.subjectMigration
dc.subjectCabazitaxel
dc.subjectEpithelial-mesenchymal transition
dc.subjectMicrorna
dc.subjectProstate cancer
dc.subjectSnail
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectOncology
dc.titleThe regulatory effect of cabazitaxel on epithelial-mesenchymal transition in metastatic prostate cancer
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication134440c4-386b-47a8-a04b-f11708a8cab2
relation.isAuthorOfPublication051cf631-d214-4c8f-b1f5-fa1d27d5269c
relation.isAuthorOfPublicationae26ce61-4a33-4336-9fe3-b40d1138c397
relation.isAuthorOfPublication.latestForDiscovery134440c4-386b-47a8-a04b-f11708a8cab2

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