Publication:
Comparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery

dc.contributor.authorGüney, Ayla
dc.contributor.authorKaya, Fatma Nur
dc.contributor.authorYavaşcaoğlu, Belgin
dc.contributor.authorGurbet, Alp
dc.contributor.authorSelmi, Nazan Has
dc.contributor.authorKaya, Şener
dc.contributor.authorKutlay, Oya
dc.contributor.buuauthorGüney, Ayla
dc.contributor.buuauthorKAYA, FATMA NUR
dc.contributor.buuauthorGURBET, ALP
dc.contributor.buuauthorYAVAŞCAOĞLU, BELGİN
dc.contributor.buuauthorSelmi, Nazan Has
dc.contributor.buuauthorKaya, Şener
dc.contributor.buuauthorKutlay, Oya
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anesteziyoloji ve Reanimasyon Anabilim Dalı.
dc.contributor.orcid0000-0003-4820-2288
dc.contributor.orcid0000-0002-6503-8232
dc.contributor.researcheridEXO-4828-2022
dc.contributor.researcheridHPG-2667-2023
dc.contributor.researcheridAAG-9356-2021
dc.contributor.researcheridA-7994-2018
dc.contributor.researcheridFVA-4074-2022
dc.contributor.researcheridCYU-8986-2022
dc.contributor.researcheridFFP-7118-2022
dc.date.accessioned2024-10-01T13:17:33Z
dc.date.available2024-10-01T13:17:33Z
dc.date.issued2012-08-01
dc.description.abstractObjective: The aim of this study was to compare esmolol to nitroglycerine in terms of effectiveness in controlling hypotension during nasal surgery.Materials and Methods: After approval by our institutional Ethics Committee, 40 patients were recruited and randomized into two drug groups: esmolol (Group E) and nitroglycerine (Group N). In group E, a bolus dose of 500 mu g/kg esmolol was administered over 30 sec followed by continuous administration at a dose of 25-300 mu g/kg/min to maintain systolic arterial pressure at 80 mmHg. In group N, nitroglycerine was administered at a dose of 0.5-2 mu g/kg/min.Results: During the hypotensive period, systolic arterial pressure, diastolic arterial pressure, mean arterial pressure, and heart rate were decreased 24%, 33%, 27% and 35%, respectively, in group E (p<0.001, p<0.001, p<0.001, p<0.001) and were decreased 30%, 33%, 34% and 23%, respectively, in group N (p<0.001, p<0.001, p<0.001, p<0.001). The decrease in heart rate was higher in group E during the hypotensive period (p=0.048). During the recovery period, diastolic arterial pressure and heart rate were decreased 9% and 18%, respectively, in group E (p=0.044, p<0.001). Systolic arterial pressure, diastolic arterial pressure, and mean arterial pressure were decreased 7%, 3% and 7%, respectively, in group N (p=0.049, p=0.451, p=0.045).Conclusion: Esmolol provides hemodynamic stability and good surgical field visibility and should be considered as an alternative to nitroglycerine.
dc.identifier.doi10.5152/eajm.2012.23
dc.identifier.endpage105
dc.identifier.issn1308-8734
dc.identifier.issue2
dc.identifier.startpage99
dc.identifier.urihttps://doi.org/10.5152/eajm.2012.23
dc.identifier.urihttps://www.eajm.org//en/comparison-of-esmolol-to-nitroglycerine-in-controlling-hypotension-during-nasal-surgery-132588
dc.identifier.urihttps://hdl.handle.net/11452/45606
dc.identifier.volume44
dc.identifier.wos000420428900008
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherAves
dc.relation.journalEurasian Journal of Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnesthesia
dc.subjectControlled hypotension
dc.subjectEsmolol hydrochloride
dc.subjectNitroglycerin
dc.subjectGeneral & internal medicine
dc.titleComparison of esmolol to nitroglycerine in controlling hypotension during nasal surgery
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication9e72832d-356c-409c-a2b1-16a2bfe825c3
relation.isAuthorOfPublication22870513-5f1d-4e85-9a57-284c8900e112
relation.isAuthorOfPublicationfc04310c-770b-4b0f-89a3-3ed0ffafbc66
relation.isAuthorOfPublication.latestForDiscovery9e72832d-356c-409c-a2b1-16a2bfe825c3

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