Publication: Evaluation of the combination treatments with intravenous fosfomycin for carbapenem-resistant Klebsiella pneumoniae
dc.contributor.buuauthor | ÖNAL, UĞUR | |
dc.contributor.buuauthor | Tüzemen, Nazmiye Ülkü | |
dc.contributor.buuauthor | TÜZEMEN, NAZMİYE ÜLKÜ | |
dc.contributor.buuauthor | Kaya, Pınar Küçükdemirci | |
dc.contributor.buuauthor | KELEBEK GİRGİN, NERMİN | |
dc.contributor.buuauthor | KÜÇÜKDEMİRCİ KAYA, PINAR | |
dc.contributor.buuauthor | İŞÇİMEN, REMZİ | |
dc.contributor.buuauthor | ÖZAKIN, CÜNEYT | |
dc.contributor.buuauthor | Özakın, Cüneyt | |
dc.contributor.buuauthor | Kahveci, Ferda Şöhret | |
dc.contributor.buuauthor | KAHVECİ, FERDA ŞÖHRET | |
dc.contributor.buuauthor | Akalın, Halis | |
dc.contributor.buuauthor | AKALIN, EMİN HALİS | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Anestezi ve Reanimasyon Anabilim Dalı. | |
dc.contributor.orcid | 0000-0003-3544-3509 | |
dc.contributor.orcid | 0000-0002-8428-8245 | |
dc.contributor.orcid | 0000-0002-5882-1632 | |
dc.contributor.orcid | 0000-0001-7530-1279 | |
dc.contributor.researcherid | JCO-3678-2023 | |
dc.contributor.researcherid | AAU-8952-2020 | |
dc.contributor.researcherid | A-4290-2018 | |
dc.date.accessioned | 2024-09-24T05:37:02Z | |
dc.date.available | 2024-09-24T05:37:02Z | |
dc.date.issued | 2023-01-01 | |
dc.description.abstract | OBJECTIVE: The aim of this study was to evaluate the combination treatments with intravenous fosfomycin for carbapenem-resistant Klebsiella pneumoniae infections in a tertiary-care center.METHODS: Between December 24, 2018 and November 21, 2022, adult patients diagnosed with bloodstream infection or ventilator-associated pneumonia due to culture-confirmed carbapenem-resistant Klebsiella pneumoniae in the anesthesiology and reanimation intensive care units were investigated retrospectively.RESULTS: There were a total of 62 patients fulfilling the study inclusion criteria. No significant difference was recorded in 14-and 30-day mortality among different types of combination regimens such as fosfomycin plus one or two antibiotic combinations. Hypokalemia (OR:5.651, 95%CI 1.019- 31.330, p=0.048) was found to be a significant risk factor for 14-day mortality, whereas SOFA score at the time of diagnosis (OR:1.497, 95%CI 1.103- 2.032, p=0.010) and CVVHF treatment (OR:6.409, 95%CI 1.395-29.433, p=0.017) were associated with 30-day mortality in multivariate analysis.CONCLUSION: In our study, high mortality rates were found in patients with bloodstream infection or ventilator-associated pneumonia due to carbapenem-resistant Klebsiella pneumoniae, and no significant difference was recorded in 14-and 30-day mortality among different types of combination regimens such as fosfomycin plus one or two antibiotic combinations. | |
dc.identifier.doi | 10.1590/1806-9282.20230727 | |
dc.identifier.issn | 0104-4230 | |
dc.identifier.issue | 11 | |
dc.identifier.uri | https://doi.org/10.1590/1806-9282.20230727 | |
dc.identifier.uri | https://hdl.handle.net/11452/45080 | |
dc.identifier.volume | 69 | |
dc.identifier.wos | 001084181200001 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Assoc Medica Brasileira | |
dc.relation.journal | Revista Da Associacao Medica Brasileira | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Fosfomycin | |
dc.subject | Bloodstream infection | |
dc.subject | Ventilator-associated pneumonia | |
dc.subject | Klebsiella pneumoniae | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Medicine, general & internal | |
dc.subject | General & internal medicine | |
dc.title | Evaluation of the combination treatments with intravenous fosfomycin for carbapenem-resistant Klebsiella pneumoniae | |
dc.type | Article | |
dspace.entity.type | Publication | |
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relation.isAuthorOfPublication | 4fb46529-3295-4383-97b1-7c494ff32c24 | |
relation.isAuthorOfPublication.latestForDiscovery | 73351d49-e518-4e6a-8f69-c922f8f24611 |
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