Publication:
Evaluation of the combination treatments with intravenous fosfomycin for carbapenem-resistant Klebsiella pneumoniae

dc.contributor.buuauthorÖNAL, UĞUR
dc.contributor.buuauthorTüzemen, Nazmiye Ülkü
dc.contributor.buuauthorTÜZEMEN, NAZMİYE ÜLKÜ
dc.contributor.buuauthorKaya, Pınar Küçükdemirci
dc.contributor.buuauthorKELEBEK GİRGİN, NERMİN
dc.contributor.buuauthorKÜÇÜKDEMİRCİ KAYA, PINAR
dc.contributor.buuauthorİŞÇİMEN, REMZİ
dc.contributor.buuauthorÖZAKIN, CÜNEYT
dc.contributor.buuauthorÖzakın, Cüneyt
dc.contributor.buuauthorKahveci, Ferda Şöhret
dc.contributor.buuauthorKAHVECİ, FERDA ŞÖHRET
dc.contributor.buuauthorAkalın, Halis
dc.contributor.buuauthorAKALIN, EMİN HALİS
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Mikrobiyoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Mikrobiyoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Anestezi ve Reanimasyon Anabilim Dalı.
dc.contributor.orcid0000-0003-3544-3509
dc.contributor.orcid0000-0002-8428-8245
dc.contributor.orcid0000-0002-5882-1632
dc.contributor.orcid0000-0001-7530-1279
dc.contributor.researcheridJCO-3678-2023
dc.contributor.researcheridAAU-8952-2020
dc.contributor.researcheridA-4290-2018
dc.date.accessioned2024-09-24T05:37:02Z
dc.date.available2024-09-24T05:37:02Z
dc.date.issued2023-01-01
dc.description.abstractOBJECTIVE: The aim of this study was to evaluate the combination treatments with intravenous fosfomycin for carbapenem-resistant Klebsiella pneumoniae infections in a tertiary-care center.METHODS: Between December 24, 2018 and November 21, 2022, adult patients diagnosed with bloodstream infection or ventilator-associated pneumonia due to culture-confirmed carbapenem-resistant Klebsiella pneumoniae in the anesthesiology and reanimation intensive care units were investigated retrospectively.RESULTS: There were a total of 62 patients fulfilling the study inclusion criteria. No significant difference was recorded in 14-and 30-day mortality among different types of combination regimens such as fosfomycin plus one or two antibiotic combinations. Hypokalemia (OR:5.651, 95%CI 1.019- 31.330, p=0.048) was found to be a significant risk factor for 14-day mortality, whereas SOFA score at the time of diagnosis (OR:1.497, 95%CI 1.103- 2.032, p=0.010) and CVVHF treatment (OR:6.409, 95%CI 1.395-29.433, p=0.017) were associated with 30-day mortality in multivariate analysis.CONCLUSION: In our study, high mortality rates were found in patients with bloodstream infection or ventilator-associated pneumonia due to carbapenem-resistant Klebsiella pneumoniae, and no significant difference was recorded in 14-and 30-day mortality among different types of combination regimens such as fosfomycin plus one or two antibiotic combinations.
dc.identifier.doi10.1590/1806-9282.20230727
dc.identifier.issn0104-4230
dc.identifier.issue11
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20230727
dc.identifier.urihttps://hdl.handle.net/11452/45080
dc.identifier.volume69
dc.identifier.wos001084181200001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherAssoc Medica Brasileira
dc.relation.journalRevista Da Associacao Medica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectFosfomycin
dc.subjectBloodstream infection
dc.subjectVentilator-associated pneumonia
dc.subjectKlebsiella pneumoniae
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectMedicine, general & internal
dc.subjectGeneral & internal medicine
dc.titleEvaluation of the combination treatments with intravenous fosfomycin for carbapenem-resistant Klebsiella pneumoniae
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication.latestForDiscovery73351d49-e518-4e6a-8f69-c922f8f24611

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