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Comparison of plasmapheresis with medical apheresis in terms of efficacy and cost in the acute treatment of hypertriglyceridemia in children with

dc.contributor.authorErdöl, Şahin
dc.contributor.authorBilgin, Hüseyin
dc.contributor.authorSağlam, Halil
dc.contributor.buuauthorERDÖL, ŞAHİN
dc.contributor.buuauthorBİLGİN, HÜSEYİN
dc.contributor.buuauthorSAĞLAM, HALİL
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentPediatri Ana Bilim Dalı
dc.contributor.departmentMetabolizma Bilim Dalı
dc.contributor.orcid0000-0002-6598-8262
dc.contributor.researcheridGLN-8241-2022
dc.contributor.researcheridJMQ-9930-2023
dc.contributor.researcheridHSF-7083-2023
dc.date.accessioned2024-06-27T07:33:49Z
dc.date.available2024-06-27T07:33:49Z
dc.date.issued2021-11-01
dc.description.abstractObjectives: We aimed to compare plasmapheresis and medical apheresis as lipid-lowering therapies in children with familial lipoprotein lipase (LPL) deficiency. Methods: The data of 13 patients who were followed up after a diagnosis of LPL deficiency were retrospectively analyzed. Plasma triglyceride, cholesterol, amylase, and lipase values and complications were recorded before and after each patient underwent plasmapheresis or medical apheresis. Results: The mean follow-up period of the patients was 99.64 +/- 52.92 months in the medical apheresis group and 118 +/- 16.97 months in the plasmapheresis group. While the mean triglyceride level before plasmapheresis was 1,875.38 +/- 547.46 mg/dL, it was 617 +/- 228.28 mg/dL after plasmapheresis. While the mean triglyceride level before medical apheresis was 1,756.86 +/- 749.27 mg/dL, it was found to be 623.03 +/- 51.36 mg/dL after medical apheresis. Triglyceride levels were decreased by 59.62% with medical apheresis and 65.57% with plasmapheresis. The cost of treatment for medical apheresis was found to be lower compared to plasmapheresis 296.93 +/- 29.94 Turkish lira (USD 43.34 +/- 4.01) vs. 3,845.42 +/- 156.17 Turkish lira (USD 561.37 +/- 20.93; p<0.001). Conclusions: Although there is no standardized strategy for the acute treatment of hypertriglyceridemia due to LPL deficiency, medical apheresis is a safe and effective treatment with a low risk of side effects. Unlike plasmapheresis, medical apheresis can be performed in any center, which is another important advantage of the procedure. A greater catabolism. diabetes, tions gene the titis, xhantoms acute zil, familial and these there treatment. ting
dc.identifier.doi10.1515/jpem-2021-0260
dc.identifier.eissn2191-0251
dc.identifier.endpage1424
dc.identifier.issn0334-018X
dc.identifier.issue11
dc.identifier.startpage1419
dc.identifier.urihttps://doi.org/10.1515/jpem-2021-0260
dc.identifier.urihttps://www.degruyter.com/document/doi/10.1515/jpem-2021-0260/html
dc.identifier.urihttps://hdl.handle.net/11452/42488
dc.identifier.volume34
dc.identifier.wos000717373400008
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWalter
dc.relation.journalJournal Of Pediatric Endocrinology & Metabolism
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLipoprotein-lipase
dc.subjectPancreatitis
dc.subjectPatient
dc.subjectInsulin
dc.subjectDeficiency
dc.subjectMutations
dc.subjectTherapy
dc.subjectHypertriglyceridemia
dc.subjectInsulin
dc.subjectLipoproteinlipase deficiency
dc.subjectMedical apheresis
dc.subjectPlasmapheresis
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectEndocrinology & metabolism
dc.subjectPediatrics
dc.titleComparison of plasmapheresis with medical apheresis in terms of efficacy and cost in the acute treatment of hypertriglyceridemia in children with
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Pediatri Ana Bilim Dalı/Metabolizma Bilim Dalı
relation.isAuthorOfPublication20f0e0ab-299b-4991-a5bc-4c6021265d5e
relation.isAuthorOfPublication2b20b93d-cba7-4607-8ff3-2122b9a800be
relation.isAuthorOfPublication0ea2245f-bcba-4a84-b68a-fdbc43ac8913
relation.isAuthorOfPublication.latestForDiscovery20f0e0ab-299b-4991-a5bc-4c6021265d5e

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