Publication:
The effects of fat graft and platelet-rich fibrin combination after epineurectomy in rats

dc.contributor.buuauthorKastamoni, Menekşe
dc.contributor.buuauthorKASTAMONİ, MENEKŞE
dc.contributor.buuauthorYavaş, Senem Esin
dc.contributor.buuauthorErsoy, Semiha
dc.contributor.buuauthorERSOY, SEMİHA
dc.contributor.buuauthorÖzgenel, Güzin Yeşim
dc.contributor.buuauthorÖZGENEL, GÜZİN YEŞİM
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi
dc.date.accessioned2024-09-09T06:13:47Z
dc.date.available2024-09-09T06:13:47Z
dc.date.issued2023-01-01
dc.description.abstractOBJECTIVE: One of the most important factors that adversely affects the outcome of peripheral nerve surgery is the formation of epineural and extraneural scar tissue after surgery. Many surgical methods and pharmacological and chemical agents have been used to prevent the formation of epineural scar tissue, but satisfactory results have not been achieved in clinical applications. The purpose of this study was to investigate the combined effect of fat graft and platelet-rich fibrin on the formation of epineural scar tissue and on nerve healing in the mature rat model.METHODS: A total of 24 female Sprague-Dawley rats were used. A circumferential segment of epineurium was excised from both bilateral sciatic nerves. The epineurectomized right nerve segment was wrapped with a combination of fat graft and platelet-rich fibrin (experimental group), while the left nerve segment did not receive any surgical procedure other than the epineurectomy (sham group). Notably, 12 randomly selected rats were sacrificed in the fourth week for histopathological examination of early results. The other 12 rats were sacrificed in the eighth week for late results.RESULTS: The formation of fibrosis, inflammation, and myelin degeneration were less common in the experimental group, while nerve regeneration was found to be higher at both 4 and 8 weeks.CONCLUSION: The intraoperative application of a combination of fat graft and platelet-rich fibrin appears to be effective on nerve healing after surgery at both the early and late periods.
dc.identifier.doi10.1590/1806-9282.20220982
dc.identifier.endpage278
dc.identifier.issn0104-4230
dc.identifier.issue2
dc.identifier.startpage272
dc.identifier.urihttps://doi.org/10.1590/1806-9282.20220982
dc.identifier.urihttps://hdl.handle.net/11452/44378
dc.identifier.volume69
dc.identifier.wos000947881200016
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherAssoc Medica Brasileira
dc.relation.journalRevista Da Associacao Medica Brasileira
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectSciatic-nerve
dc.subjectReduction
dc.subjectMigration
dc.subjectCells
dc.subjectSciatic neuropathy
dc.subjectNerve regeneration
dc.subjectPlatelet-rich fibrin
dc.subjectAdipose tissue
dc.subjectReceptor
dc.subjectEpha4
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectMedicine, general & internal
dc.subjectGeneral & internal medicine
dc.titleThe effects of fat graft and platelet-rich fibrin combination after epineurectomy in rats
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationa306b84f-ba15-42f3-ac24-3bacc93f7b83
relation.isAuthorOfPublicationd75314df-3a74-4823-81f2-d62cf576c6df
relation.isAuthorOfPublication3c738968-ecbd-4034-82f6-d3bc1da94b7a
relation.isAuthorOfPublication.latestForDiscoverya306b84f-ba15-42f3-ac24-3bacc93f7b83

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