Publication:
The clinical impacts of the controlling nutritional status score on patients with hodgkin lymphoma

dc.contributor.authorGürsoy, V.
dc.contributor.authorPinar, I. -E.
dc.contributor.authorAli, R.
dc.contributor.buuauthorHunutlu, Fazıl Çağrı
dc.contributor.buuauthorGÖKTUĞ, MEHMET REFİK
dc.contributor.buuauthorHUNUTLU, FAZIL ÇAĞRI
dc.contributor.buuauthorÖzkocaman, Vildan
dc.contributor.buuauthorÖZKOCAMAN, VİLDAN
dc.contributor.buuauthorÖzkalemkaş, Fahir
dc.contributor.buuauthorÖZKALEMKAŞ, FAHİR
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Hematoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı
dc.date.accessioned2024-10-16T05:53:31Z
dc.date.available2024-10-16T05:53:31Z
dc.date.issued2023-10-01
dc.description.abstractOBJECTIVE: The aim of the study was to evaluate the clinical importance and potential mechanisms of controlling nutritional status (CONUT) score as a prognostic tool for Hodgkin lymphoma (HL). PATIENTS AND METHODS: Diagnosed with HL, 307 patients were included in the study. Patients' demographic data, stages, B symptoms, extranodal involvement, presence of bulky disease, laboratory findings, treatments, treatment responses, nutritional status, and overall survival (OS) rates were evaluated from the hospital records. The pri-mary endpoint of our study was to evaluate and classify newly diagnosed HL patients under the CONUT score. The secondary endpoint was to indicate any relationship between nutritional status, CONUT score, and other prognostic factors and OS.RESULTS: Of 307 patients (173 males, 134 females), the mean age was 41.58 +/- 16.26 (ranging between 18-82 years). The most common type of malignancy was nodular sclerosis (72.53%). To the receiver operating characteristic (ROC) curve analysis, the best cut-off point was 2.5 to predict mortality. Eigthy-five (27.7%) and 222 (72.3%) patients had >= 3 and <= 2 CONUT scores, respectively. Twenty-four (10.80%) and 23 (27.10%) cases were also mortal in the patients with <= 2 and >= 3 CONUT scores, respectively (p<0.001). Survival times were significantly lower in those with higher (>= 3) CONUT scores (p<0.001) than among the other patients.CONCLUSIONS: Evaluation of nutritional status plays an important role in the response and survival of those with hematological malignancies. Malnutrition can reduce patients' tolerance to chemotherapy and increase the risk of secondary infections. In this study, undernutrition evaluated with the CONUT score was demonstrated to be a potential independent prognostic factor for OS in patients with HL.
dc.identifier.endpage9927
dc.identifier.issn1128-3602
dc.identifier.issue20
dc.identifier.startpage9916
dc.identifier.urihttps://hdl.handle.net/11452/46492
dc.identifier.volume27
dc.identifier.wos001113903000038
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherVerduci Publisher
dc.relation.journalEuropean Review For Medical And Pharmacological Sciences
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPrognostic impact
dc.subjectCell
dc.subjectPoor
dc.subjectSurvival
dc.subjectAlbumin
dc.subjectCount
dc.subjectConut
dc.subjectRatio
dc.subjectDiabetes mellitus. controlling nutritional status score
dc.subjectHodgkin lymphoma
dc.subjectMalnutrition
dc.subjectOverall survival
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectPharmacology & pharmacy
dc.titleThe clinical impacts of the controlling nutritional status score on patients with hodgkin lymphoma
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationd1fe2bb6-11d1-46bd-b9fd-523bec760729
relation.isAuthorOfPublication6e52e5e1-b960-43bc-bd41-4cc11d8dde87
relation.isAuthorOfPublication516d4442-e436-45a6-87b9-741a9e213d31
relation.isAuthorOfPublication6d4676a2-f825-4560-bfa8-c7eb6daf748d
relation.isAuthorOfPublication.latestForDiscoveryd1fe2bb6-11d1-46bd-b9fd-523bec760729

Files

Collections