Publication: The clinical impacts of the controlling nutritional status score on patients with hodgkin lymphoma
dc.contributor.author | Gürsoy, V. | |
dc.contributor.author | Pinar, I. -E. | |
dc.contributor.author | Ali, R. | |
dc.contributor.buuauthor | Hunutlu, Fazıl Çağrı | |
dc.contributor.buuauthor | GÖKTUĞ, MEHMET REFİK | |
dc.contributor.buuauthor | HUNUTLU, FAZIL ÇAĞRI | |
dc.contributor.buuauthor | Özkocaman, Vildan | |
dc.contributor.buuauthor | ÖZKOCAMAN, VİLDAN | |
dc.contributor.buuauthor | Özkalemkaş, Fahir | |
dc.contributor.buuauthor | ÖZKALEMKAŞ, FAHİR | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Hematoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı | |
dc.date.accessioned | 2024-10-16T05:53:31Z | |
dc.date.available | 2024-10-16T05:53:31Z | |
dc.date.issued | 2023-10-01 | |
dc.description.abstract | OBJECTIVE: The aim of the study was to evaluate the clinical importance and potential mechanisms of controlling nutritional status (CONUT) score as a prognostic tool for Hodgkin lymphoma (HL). PATIENTS AND METHODS: Diagnosed with HL, 307 patients were included in the study. Patients' demographic data, stages, B symptoms, extranodal involvement, presence of bulky disease, laboratory findings, treatments, treatment responses, nutritional status, and overall survival (OS) rates were evaluated from the hospital records. The pri-mary endpoint of our study was to evaluate and classify newly diagnosed HL patients under the CONUT score. The secondary endpoint was to indicate any relationship between nutritional status, CONUT score, and other prognostic factors and OS.RESULTS: Of 307 patients (173 males, 134 females), the mean age was 41.58 +/- 16.26 (ranging between 18-82 years). The most common type of malignancy was nodular sclerosis (72.53%). To the receiver operating characteristic (ROC) curve analysis, the best cut-off point was 2.5 to predict mortality. Eigthy-five (27.7%) and 222 (72.3%) patients had >= 3 and <= 2 CONUT scores, respectively. Twenty-four (10.80%) and 23 (27.10%) cases were also mortal in the patients with <= 2 and >= 3 CONUT scores, respectively (p<0.001). Survival times were significantly lower in those with higher (>= 3) CONUT scores (p<0.001) than among the other patients.CONCLUSIONS: Evaluation of nutritional status plays an important role in the response and survival of those with hematological malignancies. Malnutrition can reduce patients' tolerance to chemotherapy and increase the risk of secondary infections. In this study, undernutrition evaluated with the CONUT score was demonstrated to be a potential independent prognostic factor for OS in patients with HL. | |
dc.identifier.endpage | 9927 | |
dc.identifier.issn | 1128-3602 | |
dc.identifier.issue | 20 | |
dc.identifier.startpage | 9916 | |
dc.identifier.uri | https://hdl.handle.net/11452/46492 | |
dc.identifier.volume | 27 | |
dc.identifier.wos | 001113903000038 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Verduci Publisher | |
dc.relation.journal | European Review For Medical And Pharmacological Sciences | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Prognostic impact | |
dc.subject | Cell | |
dc.subject | Poor | |
dc.subject | Survival | |
dc.subject | Albumin | |
dc.subject | Count | |
dc.subject | Conut | |
dc.subject | Ratio | |
dc.subject | Diabetes mellitus. controlling nutritional status score | |
dc.subject | Hodgkin lymphoma | |
dc.subject | Malnutrition | |
dc.subject | Overall survival | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Pharmacology & pharmacy | |
dc.title | The clinical impacts of the controlling nutritional status score on patients with hodgkin lymphoma | |
dc.type | Article | |
dspace.entity.type | Publication | |
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