Publication:
Neutralizing antibody titers against field strains of bovine viral diarrhea virus after vaccination with three commercial vaccines

dc.contributor.authorAlpay, Gizem
dc.contributor.authorYeşilbağ, Kadir
dc.contributor.buuauthorAlpay, Gizem
dc.contributor.buuauthorYEŞİLBAĞ, KADİR
dc.contributor.departmentUludağ Üniversitesi/Veteriner Fakültesi/Viroloji Anabilim Dalı
dc.contributor.orcid0000-0002-3411-081X
dc.contributor.orcid0000-0003-1793-6879
dc.contributor.researcheridAAH-3917-2021
dc.contributor.researcheridABE-7662-2020
dc.date.accessioned2024-10-07T06:10:29Z
dc.date.available2024-10-07T06:10:29Z
dc.date.issued2019-01-01
dc.description.abstractModified killed vaccines against bovine viral diarrhea virus (BVDV) are used worldwide. In the present study, the cross-neutralization antibody responses against field strains from seven subgenotypes of BVDV-1 and one subgenotype of BVDV-2 were evaluated using sera obtained by three inactivated commercial vaccines. One vaccine contained both BVDV-1 and BVDV-2 strains, while the others contained only BVDV-1a. Three vaccine groups, each containing five calves, were vaccinated two times with 30-day intervals. The antibody titers were evaluated by virus neutralization assay. The monovalent vaccine induced the highest antibody titers. Significant levels of neutralizing antibody titers were maintained up to the last sampling time. Although one vaccine contained the BVDV-2 strain, the lowest antibody titers were detected against field strains from BVDV-2, BVDV-1b, and BVDV-1r. This study indicated that cross-protective immune responses with the most common international BVDV vaccine strains need to be evaluated with challenge experiments against field strains for efficient protection.
dc.identifier.doi10.3906/vet-1803-43
dc.identifier.endpage723
dc.identifier.issn1300-0128
dc.identifier.issue6
dc.identifier.startpage716
dc.identifier.urihttps://doi.org/10.3906/vet-1803-43
dc.identifier.urihttps://journals.tubitak.gov.tr/veterinary/vol43/iss6/2/
dc.identifier.urihttps://hdl.handle.net/11452/45932
dc.identifier.volume43
dc.identifier.wos000500746600002
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherTübitak Bilimsel ve Teknolojik Araştırma Kurumu
dc.relation.bap2010/43
dc.relation.journalTürkiye Veteriner ve Hayvan Bilimleri Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak109 0 762
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFetal protection
dc.subjectModified-live
dc.subjectBvdv strains
dc.subjectGenotype
dc.subjectImpact
dc.subjectHeterogeneity
dc.subjectChallenge
dc.subjectInfection
dc.subjectDiversity
dc.subjectExposure
dc.subjectBovine viral diarrhea
dc.subjectInactivated vaccine
dc.subjectField strains
dc.subjectSubgenotype
dc.subjectNeutralizing antibody
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectVeterinary sciences
dc.titleNeutralizing antibody titers against field strains of bovine viral diarrhea virus after vaccination with three commercial vaccines
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationb5374809-7a56-4b86-973f-11b3cce21a21
relation.isAuthorOfPublication.latestForDiscoveryb5374809-7a56-4b86-973f-11b3cce21a21

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