Publication:
Predictors for the risk and severity of post-thrombotic syndrome in vascular Behcet's disease

dc.contributor.authorAksoy, Aysun
dc.contributor.authorÇolak, Seda
dc.contributor.authorYağız, Burcu
dc.contributor.authorCoşkun, Belkıs Nihan
dc.contributor.authorOmma, Ahmet
dc.contributor.authorYıldız, Yasin
dc.contributor.authorSarı, Alper
dc.contributor.authorAtaş, Nuh
dc.contributor.authorIlgın, Can
dc.contributor.authorKaradağ, Ömer
dc.contributor.authorErden, Abdulsamet
dc.contributor.authorDalkılıç, Ediz
dc.contributor.authorBolca, Naile
dc.contributor.authorErgelen, Rabia
dc.contributor.authorOnur, Mehmet Ruhi
dc.contributor.authorDireskeneli, Haner
dc.contributor.authorAlibaz-Öner, Fatma
dc.contributor.buuauthorYAĞIZ, BURCU
dc.contributor.buuauthorCOŞKUN, BELKIS NİHAN
dc.contributor.buuauthorBOLCA TOPAL, NAİLE
dc.contributor.buuauthorDALKILIÇ, HÜSEYİN EDİZ
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Romatoloji Bilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Radyoloji Anabilim Dalı.
dc.contributor.orcid0000-0003-0298-4157
dc.contributor.researcheridJQW-5031-2023
dc.contributor.researcheridAAG-7155-2021
dc.contributor.researcheridCMF-4757-2022
dc.contributor.researcheridEKW-9201-2022
dc.date.accessioned2024-06-12T10:18:33Z
dc.date.available2024-06-12T10:18:33Z
dc.date.issued2021-02-04
dc.description.abstractObjective: Deep vein thrombosis (DVT) of the lower extremities is the most common form of vascular involvement in Behcet disease (BD), frequently leading to post-thrombotic syndrome (PTS) as a disabling complication. We have described the clinical characteristics and predictors of PTS presence among patients with BD and lower extremity DVT. We also used venous Doppler ultrasound (US) examinations in our assessment. Methods: Patients with BD (n = 205; 166 men, 39 women; age 39 6 9.5 years) and a history of DVT were investigated. The Villalta scale was used to assess the presence and severity of PTS. Doppler US examinations were performed within 1 week of the clinical evaluation. The total number of vessels with reflux, thrombi, recanalization, and collateral vessels were calculated. Results: Of the 205 patients with BD, 62% had had PTS and 18% had had severe PTS. Patients with PTS had had greater reflux (P = .054) and thrombosis (P = .02) scores compared with patients without PTS. Treatment with anticoagulation (AC), immunosuppressive (IS) therapy, or AC combined with IS drugs did not affect the occurrence of PTS. However, patients treated with IS therapy, with or without AC drugs, had a decreased incidence of severe PTS compared with the AC-only group (P = .017). Patients treated with AC plus IS agents also had increased collateral scores compared with patients treated with only IS drugs. Interferon-a use seemed to provide better recanalization scores compared with azathioprine only (1.0 [range, 0-14] vs 2.5 [range, 0-10]; P = .010). Conclusions: Patients with BD and DVT have a high risk of developing severe PTS. IS treatment decreases the development of severe PTS. AC therapy might influence the course of PTS by increasing the collateral scores, and the use of interferon-a also increased recanalization scores. Routine assessment with Doppler US examinations could be helpful in the prediction of severe PTS.
dc.identifier.doi10.1016/j.jvsv.2021.02.007
dc.identifier.endpage1459
dc.identifier.issn2213-333X
dc.identifier.issue6
dc.identifier.startpage1451
dc.identifier.urihttps://doi.org/10.1016/j.jvsv.2021.02.007
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S2213333X21000913
dc.identifier.urihttps://hdl.handle.net/11452/42057
dc.identifier.volume9
dc.identifier.wos000714088700015
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherElsevier
dc.relation.journalJournal of Vascular Surgery-Venous and Lymphatic Disorders
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectDeep-vein thrombosis
dc.subjectVenous disease
dc.subject1st episode
dc.subjectFollow-up
dc.subjectQuality
dc.subjectThromboembolism
dc.subjectWarfarin
dc.subjectSystem
dc.subjectReflux
dc.subjectAnticoagulation
dc.subjectBehcet disease
dc.subjectDeep vein thrombosis
dc.subjectDvt
dc.subjectImmunosuppressive agents
dc.subjectPost-thrombotic syndrome
dc.subjectSurgery
dc.subjectCardiovascular system & cardiology
dc.titlePredictors for the risk and severity of post-thrombotic syndrome in vascular Behcet's disease
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication1613225c-2f43-4052-9f82-210c854edcf4
relation.isAuthorOfPublication.latestForDiscovery02b3cfbb-e8e7-4a95-b025-294888ae9a91

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