Publication: Invasive pulmonary aspergillosis in acute leukemia: Current issues for pathogenesis, diagnosis and treatment
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Date
2006-01-01
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Bentham Science
Abstract
Invasive pulmonary aspergillosis (IPA) is a frequently life-threatening fungal infection that complicates acute leukemia patients following conventional chemotherapy and bone marrow transplantation. The mortality rate reaches 50% in leukemic patients during chemotherapy-induced neutropenia and can exceed 90% in bone marrow transplantation patients. Despite advances in antimicrobial therapy and supportive care, IPA remains a major clinical problem in patients with acute leukemia. Current issues for IPA in adults are reviewed.
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Keywords
Stem-cell transplantation, Linked-immunosorbent-assay, Polymerase-chain-reaction, Liposomal amphotericin-b, Acute myeloid-leukemia, Bronchoalveolar lavage samples, Empirical antifungal therapy, Working-party agiho, Fungal-infections, Bone-marrow, Invasive pulmonary aspergillosis (ipa), Acute leukemia, Science & technology, Life sciences & biomedicine, Respiratory system
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