Publication:
Incidence and management of thromboembolism in patients with acute leukemia

dc.contributor.authorTemuroğlu, Aytuel
dc.contributor.buuauthorGüler, Salih
dc.contributor.buuauthorGÜLER, SALİH
dc.contributor.buuauthorEvim, Melike Sezgin
dc.contributor.buuauthorSEZGİN EVİM, MELİKE
dc.contributor.buuauthorGüneş, Adalet Meral
dc.contributor.buuauthorMERAL GÜNEŞ, ADALET
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Pediatri Hemotoloji Anabilim Dalı.
dc.date.accessioned2024-09-09T11:40:39Z
dc.date.available2024-09-09T11:40:39Z
dc.date.issued2023-03-29
dc.description.abstractThromboembolic events (TE) in childhood are relatively rare but, serious complications of acute leukemia. The aim was to define the incidence and risk factors of thrombosis in children with leukemias. The electronic files of pediatric denovo/relapsed acute leukemia patients aged below 18 years, treated between 2011 and 2021 were retrospectively evaluated for thrombotic attacks. Thirty out of 469 patients developed 35 thrombotic events. The median age at the time of the TE was 11.8 (2-17.6) years, and the median time from diagnosis to TE was 9 (0-58) months. The frequency of TE was found at 7.4% ( n = 35/469). When catheter related (n = 13) events, superficial venous events (n = 10), and arterial central nervous system thrombosis (n = 1) were excluded, the frequency of TE was decreased to 2.3% (n = 11/469). Children older than 10 years old (13.8%; n = 21/152) had significantly higher thromboembolic events than the others (4.4%; n = 14/317) (p = 0.03). The majority of attacks were symptomatic 66% (n = 23/35). The most common complaints were local pain, swelling, and redness 52% (n = 12/23). The majority of attacks in patients with relapsed (75%; 6/8) and newly diagnosed acute lymphoblastic leukemia (40%; 10/25%) developed during the induction phase. Thrombosis recurred in 13.3% (n = 4/30) of cases more than once. Thrombotic attacks were successfully treated with low molecular weight heparin 60% (n = 21/35), and recombinant tissue plasminogen activator 17% (n = 6/35). None of the children were lost due to thrombosis. Thrombosis is an important complication during acute leukemia treatment.Successful results are obtained with early diagnosis and treatment attempts by creating awareness.
dc.identifier.doi10.1007/s12288-023-01642-5
dc.identifier.endpage648
dc.identifier.issn0971-4502
dc.identifier.issue4
dc.identifier.startpage642
dc.identifier.urihttps://doi.org/10.1007/s12288-023-01642-5
dc.identifier.urihttps://hdl.handle.net/11452/44415
dc.identifier.volume39
dc.identifier.wos000960269300002
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSpringer India
dc.relation.journalIndian Journal Of Hematology And Blood Transfusion
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAcute lymphoblastic-leukemia
dc.subjectOne single-center
dc.subjectRisk-factors
dc.subjectVenous thromboembolism
dc.subjectChildren
dc.subjectThrombosis
dc.subjectChildhood
dc.subjectComplications
dc.subjectEpidemiology
dc.subjectPathogenesis
dc.subjectAcute leukemia
dc.subjectChildhood
dc.subjectVenous thromboembolism
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectHematology
dc.titleIncidence and management of thromboembolism in patients with acute leukemia
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublicatione5dd9c52-ff4f-4fd0-9e37-2a7972f2b05f
relation.isAuthorOfPublication500825a8-5e0f-481f-a84f-d7fb8759c049
relation.isAuthorOfPublication.latestForDiscovery8ef9e002-892e-459a-80e7-cf08b69c48bb

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