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Expression profile of prostaglandin enzymes in cystic endometrial hyperplasia in dogs: The results of a hypothesis in clinical trial

dc.contributor.authorKorlu, Yeşim
dc.contributor.authorYavaş, Özkan
dc.contributor.authorAktar, Ahmet
dc.contributor.authorBozkurt, Berkay
dc.contributor.authorÖzyiğit, Musa Özgür
dc.contributor.authorÖzalp, Gözde Rabia
dc.contributor.buuauthorKorlu, Yeşim
dc.contributor.buuauthorYAVAŞ, ÖZKAN
dc.contributor.buuauthorAktar, Ahmet
dc.contributor.buuauthorÖZYİĞİT, MUSA ÖZGÜR
dc.contributor.buuauthorÖZALP, RABİA GÖZDE
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi/Jinekoloji ve Doğum Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi/Patoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi/Döreme ve Suni Tohumlama Anabilim Dalı.
dc.contributor.orcid0000-0002-2975-2594
dc.contributor.researcheridAAE-3607-2019
dc.contributor.researcheridKHD-4075-2024
dc.contributor.researcheridCZR-5232-2022
dc.contributor.researcheridCBC-1744-2022
dc.contributor.researcheridHPY-3936-2023
dc.date.accessioned2024-09-30T09:15:23Z
dc.date.available2024-09-30T09:15:23Z
dc.date.issued2023-01-30
dc.description.abstractThe expressions of prostaglandin synthesis enzymes and estrogen, progesterone receptors in canine cystic endometrial hyperplasia (CEH) were reported in this manuscript. Uterine tissue samples were collected from bitches with CEH (n=5), CEH-P (Cystic endometrial hyperplasia-Pyometra) (n=5) and healthy-negative control group, CG (n=5). Immunohistochemistry was carried out for the estrogen (ER) and progesterone receptor (PR) detection. Shock-frozen samples were utilized in mRNA extraction and Real-Time PCR was performed. Gene expression of PTGS2/COX2, PTGES, PTGER4, PGFS, PTGFR and PGR were detected higher in the CEH group compared with CG. The PGFS and PTGFR (FP) mRNA expressions were significantly increased in CEH compared with other groups. Expression of progesterone receptor mRNA (PGR) was highest in CEH and statistically different from the CEH-P group (P<0.05). No PR immunostaining was observed. ER staining had been detected in endometrial glands, endometrial stoma and myometrium, however hyperplasic glands in propria mucosa had lower or no ER scores. Based on the results of this study, the high levels of prostaglandin enzymes and low ER scores in CEH could be a preliminary step for the next stages of severe differentiation of endometrium.
dc.identifier.doi10.9775/kvfd.2022.28403
dc.identifier.issn1300-6045
dc.identifier.issue1
dc.identifier.urihttps://doi.org/10.9775/kvfd.2022.28403
dc.identifier.urihttps://vetdergikafkas.org/uploads/pdf/pdf_KVFD_2970.pdf
dc.identifier.urihttps://hdl.handle.net/11452/45487
dc.identifier.volume29
dc.identifier.wos000927093100001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherKafkas Üniversitesi
dc.relation.bapDDP(V)-2020/8
dc.relation.journalKafkas Üniversitesi Veteriner Fakültesi Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectToll-like receptors
dc.subjectPyometra
dc.subjectCanine
dc.subjectCycle
dc.subjectCyclooxygenase-2
dc.subjectEstrogen
dc.subjectBitch
dc.subjectCanine
dc.subjectCystic endometrial hyperplasia
dc.subjectEstrogen receptor
dc.subjectProstaglandin
dc.subjectVeterinary sciences
dc.titleExpression profile of prostaglandin enzymes in cystic endometrial hyperplasia in dogs: The results of a hypothesis in clinical trial
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication0d63584e-e8de-4da8-bb8b-1278c8c29973
relation.isAuthorOfPublication3a2cbbbb-163d-428a-9caa-27708d631560
relation.isAuthorOfPublication365bc240-97b6-4a40-9d05-c605d3375637
relation.isAuthorOfPublication.latestForDiscovery0d63584e-e8de-4da8-bb8b-1278c8c29973

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