Publication:
Design, synthesis and anticancer activity of new benzofuran-chalcone hybrids and their water soluble sodium salts

dc.contributor.authorCoskun, Demet
dc.contributor.authorCoşkun, Mehmet Fatih
dc.contributor.buuauthorÇınar-Asa, Sibel
dc.contributor.buuauthorAkgün, Oğuzhan
dc.contributor.buuauthorAkgün, Halime
dc.contributor.buuauthorArı, Ferda
dc.contributor.buuauthorARI, FERDA
dc.contributor.departmentBursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Biyoloji Bölümü.
dc.contributor.orcid0000-0002-8410-1786
dc.contributor.orcid0000-0002-2048-3252
dc.contributor.orcid0000-0002-6729-7908
dc.contributor.researcheridA-5608-2019
dc.contributor.researcheridADX-9980-2022
dc.contributor.researcheridAAG-7012-2021
dc.date.accessioned2024-09-10T05:57:19Z
dc.date.available2024-09-10T05:57:19Z
dc.date.issued2023-03-06
dc.description.abstractIn this study, firstly, 1-(7-ethoxy-1-benzofuran-2-yl) ethanone and 1,1'-(7-ethoxy-1-benzofuran-2,4-diyl)diethanone were synthesized for the starting reagent purposes. The synthesized benzofuran-chalcone salts were soluble in water at room temperature. Structural analysis of the synthesized compounds was characterized by elemental analysis, FT-IR and NMR spectroscopy techniques. The anticancer activities of the compounds were determined by SRB viability assay in human lung cancer (A549, H1299) and breast cancer (MCF-7, MDA-MB-231) cell lines. Findings for apoptosis were determined by flow cytometry analysis and the PARP-ELISA method. The results of the in vitro SRB analysis of the compounds showed that some of the chalcone hybrids were very effective on both types of cancer in a dose and time-dependent manner. Treatment of all cancer cell types with these hybrids resulted in a significant increase in the percentage of early and mainly late apoptotic cells, demonstrating their apoptosis-inducing effects via the Caspase 3/7 Activity.
dc.description.sponsorship100/2000 Council of Higher Education (CoHE)
dc.identifier.doi10.1002/slct.202204402
dc.identifier.issn2365-6549
dc.identifier.issue9
dc.identifier.urihttps://doi.org/10.1002/slct.202204402
dc.identifier.urihttps://hdl.handle.net/11452/44443
dc.identifier.volume8
dc.identifier.wos000940798800001
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWiley-v C H Verlag Gmbh
dc.relation.journalChemistryselect
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.relation.tubitak119Z727
dc.relation.tubitak100/2000
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectDiels-alder adducts
dc.subjectBreast-cancer
dc.subjectDerivatives
dc.subjectCaspase-3
dc.subjectAgents
dc.subjectConstituents
dc.subjectPotency
dc.subjectRoles
dc.subjectAnticancer activity
dc.subjectApoptosis
dc.subjectBenzofuran
dc.subjectChalcone
dc.subjectCytotoxicity
dc.subjectScience & technology
dc.subjectPhysical sciences
dc.subjectChemistry, multidisciplinary
dc.subjectChemistry
dc.titleDesign, synthesis and anticancer activity of new benzofuran-chalcone hybrids and their water soluble sodium salts
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication1dd517bb-3e11-411e-a8db-27d448dcd55e
relation.isAuthorOfPublication.latestForDiscovery1dd517bb-3e11-411e-a8db-27d448dcd55e

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