Publication: Design, synthesis and anticancer activity of new benzofuran-chalcone hybrids and their water soluble sodium salts
dc.contributor.author | Coskun, Demet | |
dc.contributor.author | Coşkun, Mehmet Fatih | |
dc.contributor.buuauthor | Çınar-Asa, Sibel | |
dc.contributor.buuauthor | Akgün, Oğuzhan | |
dc.contributor.buuauthor | Akgün, Halime | |
dc.contributor.buuauthor | Arı, Ferda | |
dc.contributor.buuauthor | ARI, FERDA | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Biyoloji Bölümü. | |
dc.contributor.orcid | 0000-0002-8410-1786 | |
dc.contributor.orcid | 0000-0002-2048-3252 | |
dc.contributor.orcid | 0000-0002-6729-7908 | |
dc.contributor.researcherid | A-5608-2019 | |
dc.contributor.researcherid | ADX-9980-2022 | |
dc.contributor.researcherid | AAG-7012-2021 | |
dc.date.accessioned | 2024-09-10T05:57:19Z | |
dc.date.available | 2024-09-10T05:57:19Z | |
dc.date.issued | 2023-03-06 | |
dc.description.abstract | In this study, firstly, 1-(7-ethoxy-1-benzofuran-2-yl) ethanone and 1,1'-(7-ethoxy-1-benzofuran-2,4-diyl)diethanone were synthesized for the starting reagent purposes. The synthesized benzofuran-chalcone salts were soluble in water at room temperature. Structural analysis of the synthesized compounds was characterized by elemental analysis, FT-IR and NMR spectroscopy techniques. The anticancer activities of the compounds were determined by SRB viability assay in human lung cancer (A549, H1299) and breast cancer (MCF-7, MDA-MB-231) cell lines. Findings for apoptosis were determined by flow cytometry analysis and the PARP-ELISA method. The results of the in vitro SRB analysis of the compounds showed that some of the chalcone hybrids were very effective on both types of cancer in a dose and time-dependent manner. Treatment of all cancer cell types with these hybrids resulted in a significant increase in the percentage of early and mainly late apoptotic cells, demonstrating their apoptosis-inducing effects via the Caspase 3/7 Activity. | |
dc.description.sponsorship | 100/2000 Council of Higher Education (CoHE) | |
dc.identifier.doi | 10.1002/slct.202204402 | |
dc.identifier.issn | 2365-6549 | |
dc.identifier.issue | 9 | |
dc.identifier.uri | https://doi.org/10.1002/slct.202204402 | |
dc.identifier.uri | https://hdl.handle.net/11452/44443 | |
dc.identifier.volume | 8 | |
dc.identifier.wos | 000940798800001 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Wiley-v C H Verlag Gmbh | |
dc.relation.journal | Chemistryselect | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.relation.tubitak | 119Z727 | |
dc.relation.tubitak | 100/2000 | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Diels-alder adducts | |
dc.subject | Breast-cancer | |
dc.subject | Derivatives | |
dc.subject | Caspase-3 | |
dc.subject | Agents | |
dc.subject | Constituents | |
dc.subject | Potency | |
dc.subject | Roles | |
dc.subject | Anticancer activity | |
dc.subject | Apoptosis | |
dc.subject | Benzofuran | |
dc.subject | Chalcone | |
dc.subject | Cytotoxicity | |
dc.subject | Science & technology | |
dc.subject | Physical sciences | |
dc.subject | Chemistry, multidisciplinary | |
dc.subject | Chemistry | |
dc.title | Design, synthesis and anticancer activity of new benzofuran-chalcone hybrids and their water soluble sodium salts | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 1dd517bb-3e11-411e-a8db-27d448dcd55e | |
relation.isAuthorOfPublication.latestForDiscovery | 1dd517bb-3e11-411e-a8db-27d448dcd55e |