Publication: The effect of capsaicin on IGF-I and IGF-IR expression in ovarian granulosa cells
dc.contributor.author | Güler, Sabire | |
dc.contributor.author | Zik, Berrin | |
dc.contributor.buuauthor | Güler, Sabire | |
dc.contributor.buuauthor | ZIK, BERRİN | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Veteriner Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı | |
dc.contributor.researcherid | AAH-9810-2021 | |
dc.contributor.researcherid | HTY-9355-2023 | |
dc.date.accessioned | 2024-07-03T06:49:42Z | |
dc.date.available | 2024-07-03T06:49:42Z | |
dc.date.issued | 2020-01-01 | |
dc.description.abstract | Capsaicin (trans-8-methyl-N-vanillyl-6-noneadamide) is a pungent ingredient in red peppers from the Capsicum family. Insulin-like growth factor-I (IGF-I) is expressed in granulosa cells and has an important role in ovarian development. However, there are no data about the IGF-I expression in ovarian granulosa cells after capsaicin treatment. The aim of this study was to investigate the expression of IGF-I and its receptor (insulin-like growth factor-I receptor [IGF-IR]) in primary rat ovarian granulosa cells after low and high doses of capsaicin treatment. For this, granulosa cells were isolated and cultured from ovaries of 30-day-old female Sprague-Dawley rats. Granulosa cell plates were divided into four groups as cell control (C), vehicle control (V), and 50 mu M and 150 mu M capsaicin groups. In experimental groups, granulosa cells were exposed to capsaicin for 24 hours and immunocytochemistry was performed afterwards using anti-IGF-I and anti-IGF-IR antibodies. Both IGF-I and IGF-IR expressions were found to be significantly increased in parallel to the capsaicin doses. Elevated levels of IGF-I may be a risk factor for ovarian development. Because of the crucial role of IGF-I in ovary development, capsaicin treatment can be effective on follicular development and/or disorders characterized by high IGF-I levels. | |
dc.identifier.doi | 10.12681/jhvms.22939 | |
dc.identifier.endpage | 1984 | |
dc.identifier.issn | 1792-2720 | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 1977 | |
dc.identifier.uri | https://doi.org/10.12681/jhvms.22939 | |
dc.identifier.uri | https://ejournals.epublishing.ekt.gr/index.php/jhvms/article/view/22939 | |
dc.identifier.uri | https://hdl.handle.net/11452/42768 | |
dc.identifier.volume | 71 | |
dc.identifier.wos | 000526941600006 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Hellenic Veterinary Medical Soc | |
dc.relation.bap | OUAP (V)-2012/4 | |
dc.relation.journal | Journal of The Hellenic Veterinary Medical Society | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Growth-factor-i | |
dc.subject | Follicle-stimulating-hormone | |
dc.subject | Gene-expression | |
dc.subject | Insulin | |
dc.subject | Receptor | |
dc.subject | Steroidogenesis | |
dc.subject | Proliferation | |
dc.subject | Trpv1 | |
dc.subject | Methoxychlor | |
dc.subject | Pepper | |
dc.subject | Ovary | |
dc.subject | Capsaicin | |
dc.subject | Igf-i | |
dc.subject | Igf-ir | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Veterinary sciences | |
dc.title | The effect of capsaicin on IGF-I and IGF-IR expression in ovarian granulosa cells | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | a30427a9-dc3b-4196-927b-d5b5b4e35e1f | |
relation.isAuthorOfPublication.latestForDiscovery | a30427a9-dc3b-4196-927b-d5b5b4e35e1f |