Publication:
The effect of capsaicin on IGF-I and IGF-IR expression in ovarian granulosa cells

dc.contributor.authorGüler, Sabire
dc.contributor.authorZik, Berrin
dc.contributor.buuauthorGüler, Sabire
dc.contributor.buuauthorZIK, BERRİN
dc.contributor.departmentBursa Uludağ Üniversitesi/Veteriner Fakültesi/Histoloji ve Embriyoloji Anabilim Dalı
dc.contributor.researcheridAAH-9810-2021
dc.contributor.researcheridHTY-9355-2023
dc.date.accessioned2024-07-03T06:49:42Z
dc.date.available2024-07-03T06:49:42Z
dc.date.issued2020-01-01
dc.description.abstractCapsaicin (trans-8-methyl-N-vanillyl-6-noneadamide) is a pungent ingredient in red peppers from the Capsicum family. Insulin-like growth factor-I (IGF-I) is expressed in granulosa cells and has an important role in ovarian development. However, there are no data about the IGF-I expression in ovarian granulosa cells after capsaicin treatment. The aim of this study was to investigate the expression of IGF-I and its receptor (insulin-like growth factor-I receptor [IGF-IR]) in primary rat ovarian granulosa cells after low and high doses of capsaicin treatment. For this, granulosa cells were isolated and cultured from ovaries of 30-day-old female Sprague-Dawley rats. Granulosa cell plates were divided into four groups as cell control (C), vehicle control (V), and 50 mu M and 150 mu M capsaicin groups. In experimental groups, granulosa cells were exposed to capsaicin for 24 hours and immunocytochemistry was performed afterwards using anti-IGF-I and anti-IGF-IR antibodies. Both IGF-I and IGF-IR expressions were found to be significantly increased in parallel to the capsaicin doses. Elevated levels of IGF-I may be a risk factor for ovarian development. Because of the crucial role of IGF-I in ovary development, capsaicin treatment can be effective on follicular development and/or disorders characterized by high IGF-I levels.
dc.identifier.doi10.12681/jhvms.22939
dc.identifier.endpage1984
dc.identifier.issn1792-2720
dc.identifier.issue1
dc.identifier.startpage1977
dc.identifier.urihttps://doi.org/10.12681/jhvms.22939
dc.identifier.urihttps://ejournals.epublishing.ekt.gr/index.php/jhvms/article/view/22939
dc.identifier.urihttps://hdl.handle.net/11452/42768
dc.identifier.volume71
dc.identifier.wos000526941600006
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherHellenic Veterinary Medical Soc
dc.relation.bapOUAP (V)-2012/4
dc.relation.journalJournal of The Hellenic Veterinary Medical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectGrowth-factor-i
dc.subjectFollicle-stimulating-hormone
dc.subjectGene-expression
dc.subjectInsulin
dc.subjectReceptor
dc.subjectSteroidogenesis
dc.subjectProliferation
dc.subjectTrpv1
dc.subjectMethoxychlor
dc.subjectPepper
dc.subjectOvary
dc.subjectCapsaicin
dc.subjectIgf-i
dc.subjectIgf-ir
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectVeterinary sciences
dc.titleThe effect of capsaicin on IGF-I and IGF-IR expression in ovarian granulosa cells
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationa30427a9-dc3b-4196-927b-d5b5b4e35e1f
relation.isAuthorOfPublication.latestForDiscoverya30427a9-dc3b-4196-927b-d5b5b4e35e1f

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