Publication: Her-2 positivity rate in dogs with mammary carcinoma: A systematic review and meta-analysis
dc.contributor.buuauthor | Uzabacı, Ender | |
dc.contributor.buuauthor | UZABACI, ENDER | |
dc.contributor.buuauthor | Özyiğit, Musa Özgür | |
dc.contributor.buuauthor | ÖZYİĞİT, MUSA ÖZGÜR | |
dc.contributor.buuauthor | Ercan, İlker | |
dc.contributor.buuauthor | Arda, O. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Veteriner Fakültesi/ Patoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Veteriner Fakültesi/ Biyoistatistik Anabilim Dalı. | |
dc.contributor.orcid | 0000-0002-9634-0055 | |
dc.contributor.orcid | 0000-0002-2382-290X | |
dc.contributor.researcherid | JPL-5273-2023 | |
dc.contributor.researcherid | ABF-2367-2020 | |
dc.contributor.researcherid | AAR-6478-2021 | |
dc.date.accessioned | 2024-07-04T12:54:13Z | |
dc.date.available | 2024-07-04T12:54:13Z | |
dc.date.issued | 2020-04-01 | |
dc.description.abstract | Human epidermal growth factor receptor 2 (HER-2) plays an essential role in cell growth and survival. HER-2 overexpression occurs in 20-30% of human breast tumors and has prognostic value as it is associated with disease progression. HER-2 overexpression is also associated with tumor progression and metastasis in malignant mammary tumors of the canine. However, in the literature, different positivity classifications/scoring were used in the evaluation of HER-2 status, and there is no consensus in terms of scoring of HER-2 expression in canine mammary tumors. In this study, it was aimed to estimate the HER-2 positivity rate by evaluating the results of the study using different positivity classifications by meta-analysis. In this context, by using "HER-2 canine mammary tumor" keywords, Pubmed and Web of Science electronic databases were scanned until February 2019, and a total of 97 related studies were found. However, 20 of these studies were used for the analysis. Two different meta-analyses were performed to evaluate the HER-2 positivity status with "2+ and 3+" and "3+" scores. As a result, HER-2 positivity rates were determined at 25.87% and 25.99% for the studies using "2+/3+" scores and "3+" respectively for HER-2 positivity. Therefore, this result suggests that the rate of HER-2 positivity is similar between humans and dogs. | |
dc.identifier.endpage | 2148 | |
dc.identifier.issn | 1792-2720 | |
dc.identifier.issue | 2 | |
dc.identifier.startpage | 2141 | |
dc.identifier.uri | https://hdl.handle.net/11452/42919 | |
dc.identifier.volume | 71 | |
dc.identifier.wos | 000558376300008 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Hellenic Veterinary Medical Soc | |
dc.relation.journal | Journal Of The Hellenic Veterinary Medical Society | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Human-breast | |
dc.subject | In-situ | |
dc.subject | Expression | |
dc.subject | Tumors | |
dc.subject | Egfr | |
dc.subject | Overexpression | |
dc.subject | Phenotype | |
dc.subject | Oncogene | |
dc.subject | Estrogen | |
dc.subject | Her-2 | |
dc.subject | Meta-analysis | |
dc.subject | Canine | |
dc.subject | Mammary tumor | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Veterinary sciences | |
dc.title | Her-2 positivity rate in dogs with mammary carcinoma: A systematic review and meta-analysis | |
dc.type | Review | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 415edb5b-1ae0-491a-bd6a-97c2d1a6ec1e | |
relation.isAuthorOfPublication | 3a2cbbbb-163d-428a-9caa-27708d631560 | |
relation.isAuthorOfPublication.latestForDiscovery | 415edb5b-1ae0-491a-bd6a-97c2d1a6ec1e |