Publication:
Evaluation of percentage recovery together with modified reference range in hyperprolactinemia

dc.contributor.buuauthorDirican, Melahat
dc.contributor.buuauthorAçıkgöz, Hacer Ebru
dc.contributor.buuauthorSarandöl, Emre
dc.contributor.buuauthorSARANDÖL, EMRE
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Biyokimya Anabilim Dalı.
dc.contributor.researcheridAAG-6985-2021
dc.contributor.researcheridABE-1716-2020
dc.date.accessioned2024-07-04T08:55:02Z
dc.date.available2024-07-04T08:55:02Z
dc.date.issued2020-02-01
dc.description.abstractObjective: Macroprolactinemia is an important cause of hyperprolactinemia. The aim of this study was to examine the added value of the consideration of modified reference range in determination of macroprolactinemia and true hyperprolactinemia.Materials and methods: Three hundred and ninety patients with high and 131 with normal prolactin (PRL) levels were included in this study. PRL had been analyzed before and after polyethylene glycol precipitation (postPEG PRL). Recovery percentage (R%) <40% and >60% had been reported as macroprolactinemia and true hyperprolactinemia, respectively. Post-PEG PRL levels were evaluated according to the modified reference range obtained from those of the normoprolactinemic subjects.Results: According to the R% criterion; macroprolactinemia had been detected in 24.9% and true hyperprolactinemia in 67.4% of hyperprolactinemic patients. When the data were evaluated considering the post-PEG PRL levels according to the modified reference range; 13 (13.4%) of the 97 macroprolactinemia reports would be considered as true hyperprolactinemia and 6 (2.3%) of the 263 true hyperprolactinemia reports would be changed as macroprolactinemia.Conclusion: Discrimination capacity of R% criterion for true hyperprolactinemia and macroprolactinemia is limited, and we suggest that, in accordance with R% criterion, laboratory reports should include the post-PEG PRL levels along with the modified reference range.
dc.identifier.doi10.1515/tjb-2018-0377
dc.identifier.endpage43
dc.identifier.issn0250-4685
dc.identifier.issue1
dc.identifier.startpage37
dc.identifier.urihttps://doi.org/10.1515/tjb-2018-0377
dc.identifier.urihttps://hdl.handle.net/11452/42890
dc.identifier.volume45
dc.identifier.wos000525736100005
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWalter De Gruyter Gmbh
dc.relation.journalTurkish Journal Of Biochemistry-turk Biyokimya Dergisi
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPolyethylene-glycol precipitation
dc.subjectMonomeric prolactin
dc.subjectReference intervals
dc.subjectClinical-practice
dc.subjectScreening method
dc.subjectMacroprolactinemia
dc.subjectValidation
dc.subjectExperience
dc.subjectHyperprolactinemia
dc.subjectMacroprolactin
dc.subjectProlactin
dc.subjectMonomeric prolactin
dc.subjectPolyethylene glycol
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectBiochemistry & molecular biology
dc.titleEvaluation of percentage recovery together with modified reference range in hyperprolactinemia
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication9529fb52-20cd-4fb3-9767-19121683aa62
relation.isAuthorOfPublication.latestForDiscovery9529fb52-20cd-4fb3-9767-19121683aa62

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