Publication:
Insulin-like growth factor-1 and morbidities of prematurity: Bronchopulmonary dysplasia, retinopathy of prematurity, intraventricular hemorrhage and necrotizing enterocolitis

dc.contributor.buuauthorÖZKAN, HİLAL
dc.contributor.buuauthorDorum, Bayram Ali
dc.contributor.buuauthorKöksal, Nilgün
dc.contributor.buuauthorÇAKIR, SALİH ÇAĞRI
dc.contributor.buuauthorÇakır, Salih Çagri
dc.contributor.buuauthorÖzgür, Taner
dc.contributor.buuauthorBudak, Ferah
dc.contributor.buuauthorYılmaz, Cansu
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentİmmunoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-2823-8454
dc.contributor.orcid0000-0001-5761-4757
dc.contributor.orcid0000-0001-7625-9148
dc.contributor.researcheridAAG-8393-2021
dc.contributor.researcheridIZP-9398-2023
dc.contributor.researcheridAEZ-2469-2022
dc.contributor.researcheridHJZ-4508-2023
dc.contributor.researcheridAAG-8381-2021
dc.contributor.researcheridF-4657-2014
dc.contributor.researcheridA-5375-2017
dc.date.accessioned2024-10-02T12:26:35Z
dc.date.available2024-10-02T12:26:35Z
dc.date.issued2019-08-01
dc.description.abstractINTRODUCTION: Insulin-like growth factor-1 (IGF-1) is important for fetal and postnatal development. After premature births, serum IGF-1 concentrations rapidly decrease and can stay at much lower levels than during the intrauterine period. In this study, we aimed to ascertain whether IGF-1 is associated with morbidities of prematurity such as bronchopulmonary dysplasia (BPD), retinopathy of prematurity (ROP), intraventricular hemorrhage (IVH), and necrotizing enterocolitis (NEC), and is a useful predictor of these diseases.METHODS: We enrolled newborn infants born at a postmenstrual age of <= 32 weeks in this prospective observational cohort study. Serum IGF-1 levels were measured serially in blood samples on the 1st, 3rd, 7th, 21st, and 28th day.RESULTS: A total of 93 infants were enrolled in the study. All these infants had the following characteristics at birth: weight 1236.11 +/- 354.06 g, and gestational age 29.43 +/- 2.10 weeks. All of the IGF-1 levels were significantly lower in the group which developed BPD or ROP (p<0.001). The patients who developed IVH and NEC also had lower IGF-1 levels.DISCUSSION and CONCLUSION: Strong correlations have been found between low serum IGF-1 levels during the first four weeks and development of BPD and ROP.
dc.identifier.endpage199
dc.identifier.issn1304-9054
dc.identifier.issue2
dc.identifier.startpage189
dc.identifier.urihttps://hdl.handle.net/11452/45692
dc.identifier.volume17
dc.identifier.wos000478577500001
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherGalenos Yayincilik
dc.relation.journalGuncel Pediatri-journal Of Current Pediatrics
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPreterm infants
dc.subjectComplications
dc.subjectIgf1
dc.subjectBronchopulmonary dysplasia
dc.subjectInsulin-like growth factor-1
dc.subjectPrematurity
dc.subjectRetinopathy of prematurity
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectPediatrics
dc.titleInsulin-like growth factor-1 and morbidities of prematurity: Bronchopulmonary dysplasia, retinopathy of prematurity, intraventricular hemorrhage and necrotizing enterocolitis
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Çocuk Sağlığı ve Hastalıkları Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/İmmunoloji Ana Bilim Dalı
relation.isAuthorOfPublication03619423-bd8d-460b-9acf-ae9ba7999208
relation.isAuthorOfPublication.latestForDiscovery03619423-bd8d-460b-9acf-ae9ba7999208

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