Publication:
microRNA-21 expression is elevated in esophageal adenocarcinoma after neoadjuvant chemotherapy

dc.contributor.authorİlhan-Mutlu, Ayşegül
dc.contributor.authorTezcan, Gülçin
dc.contributor.authorSchoppmann, Sebastian F.
dc.contributor.authorPreusser, Matthias
dc.contributor.authorSpyridoula, Kommata
dc.contributor.authorKaranikas, Georgios
dc.contributor.authorBirner, Peter
dc.contributor.buuauthorTEZCAN, GÜLÇİN
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı.
dc.contributor.orcid0000-0002-5956-8755
dc.contributor.researcheridAAH-3843-2020
dc.date.accessioned2024-08-12T11:17:17Z
dc.date.available2024-08-12T11:17:17Z
dc.date.issued2015-01-01
dc.description.abstractWe investigated whether microRNA-21 and microRNA-148a are predictive for neoadjuvant treatment in esophageal adenocarcinoma. Thirty-six patients with neoadjuvant therapy and surgical resection were included. FFPE tissue from biopsy and esophagectomy were analyzed using RT-qPCR. Results were correlated to histological tumor regression, histopathological variables, FDG-PET-CT and survival. MicroRNA-21 was significantly higher in esophagectomies than in corresponding biopsies (p = .027). No association of microRNA-21 or micro RNA-148a expression in tissue specimens with other clinical parameters was present. Although no influence of microRNA-21 and microRNA-148a on the response to neoadjuvant therapy was seen, upregulation of micro RNA-21 might represent an escape mechanism of tumor cells.
dc.description.sponsorshipMedical University of Vienna
dc.identifier.doi10.3109/07357907.2015.1024319
dc.identifier.endpage250
dc.identifier.issn0735-7907
dc.identifier.issue6
dc.identifier.startpage246
dc.identifier.urihttps://doi.org/10.3109/07357907.2015.1024319
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.3109/07357907.2015.1024319
dc.identifier.urihttps://hdl.handle.net/11452/43922
dc.identifier.volume33
dc.identifier.wos000361308900006
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherTaylor & Francis
dc.relation.journalCancer Investigation
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectPrognostic-significance
dc.subjectCancer
dc.subjectInvasion
dc.subjectProliferation
dc.subjectTherapy
dc.subjectEsophageal cancer
dc.subjectAdenocarcinoma
dc.subjectmicroRNA-21
dc.subjectmicroRNA-148a
dc.subjectNeoadjuvant therapy
dc.subjectFDG-PET-CT
dc.subjectOncology
dc.titlemicroRNA-21 expression is elevated in esophageal adenocarcinoma after neoadjuvant chemotherapy
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicatione171a866-0a2e-4df4-9f4b-d9058971c979
relation.isAuthorOfPublication.latestForDiscoverye171a866-0a2e-4df4-9f4b-d9058971c979

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