Publication: microRNA-21 expression is elevated in esophageal adenocarcinoma after neoadjuvant chemotherapy
dc.contributor.author | İlhan-Mutlu, Ayşegül | |
dc.contributor.author | Tezcan, Gülçin | |
dc.contributor.author | Schoppmann, Sebastian F. | |
dc.contributor.author | Preusser, Matthias | |
dc.contributor.author | Spyridoula, Kommata | |
dc.contributor.author | Karanikas, Georgios | |
dc.contributor.author | Birner, Peter | |
dc.contributor.buuauthor | TEZCAN, GÜLÇİN | |
dc.contributor.department | Uludağ Üniversitesi/Tıp Fakültesi/Tıbbi Biyoloji Anabilim Dalı. | |
dc.contributor.orcid | 0000-0002-5956-8755 | |
dc.contributor.researcherid | AAH-3843-2020 | |
dc.date.accessioned | 2024-08-12T11:17:17Z | |
dc.date.available | 2024-08-12T11:17:17Z | |
dc.date.issued | 2015-01-01 | |
dc.description.abstract | We investigated whether microRNA-21 and microRNA-148a are predictive for neoadjuvant treatment in esophageal adenocarcinoma. Thirty-six patients with neoadjuvant therapy and surgical resection were included. FFPE tissue from biopsy and esophagectomy were analyzed using RT-qPCR. Results were correlated to histological tumor regression, histopathological variables, FDG-PET-CT and survival. MicroRNA-21 was significantly higher in esophagectomies than in corresponding biopsies (p = .027). No association of microRNA-21 or micro RNA-148a expression in tissue specimens with other clinical parameters was present. Although no influence of microRNA-21 and microRNA-148a on the response to neoadjuvant therapy was seen, upregulation of micro RNA-21 might represent an escape mechanism of tumor cells. | |
dc.description.sponsorship | Medical University of Vienna | |
dc.identifier.doi | 10.3109/07357907.2015.1024319 | |
dc.identifier.endpage | 250 | |
dc.identifier.issn | 0735-7907 | |
dc.identifier.issue | 6 | |
dc.identifier.startpage | 246 | |
dc.identifier.uri | https://doi.org/10.3109/07357907.2015.1024319 | |
dc.identifier.uri | https://www.tandfonline.com/doi/full/10.3109/07357907.2015.1024319 | |
dc.identifier.uri | https://hdl.handle.net/11452/43922 | |
dc.identifier.volume | 33 | |
dc.identifier.wos | 000361308900006 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Taylor & Francis | |
dc.relation.journal | Cancer Investigation | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Prognostic-significance | |
dc.subject | Cancer | |
dc.subject | Invasion | |
dc.subject | Proliferation | |
dc.subject | Therapy | |
dc.subject | Esophageal cancer | |
dc.subject | Adenocarcinoma | |
dc.subject | microRNA-21 | |
dc.subject | microRNA-148a | |
dc.subject | Neoadjuvant therapy | |
dc.subject | FDG-PET-CT | |
dc.subject | Oncology | |
dc.title | microRNA-21 expression is elevated in esophageal adenocarcinoma after neoadjuvant chemotherapy | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | e171a866-0a2e-4df4-9f4b-d9058971c979 | |
relation.isAuthorOfPublication.latestForDiscovery | e171a866-0a2e-4df4-9f4b-d9058971c979 |