Publication:
Risk factors affecting oncological outcomes of surgical resections for middle and lower rectal cancer

dc.contributor.authorTırnova, İsmail
dc.contributor.authorIşık, Özgen
dc.contributor.authorYılmazlar, Ahmet Tuncay
dc.contributor.buuauthorTırnova, İsmail
dc.contributor.buuauthorIŞIK, ÖZGEN
dc.contributor.buuauthorYILMAZLAR, AHMET TUNCAY
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı/Kolorektal Cerrahi Bilim Dalı.
dc.contributor.orcid0000-0003-4488-1607
dc.contributor.orcid0000-0002-9541-5035
dc.contributor.researcheridAAW-9602-2020
dc.contributor.researcheridISB-9235-2023
dc.contributor.researcheridT-7494-2017
dc.contributor.researcheridJOH-0415-2023
dc.date.accessioned2024-09-30T05:46:43Z
dc.date.available2024-09-30T05:46:43Z
dc.date.issued2023-09-01
dc.description.abstractObjective: In our study, it was aimed to evaluate the factors affecting oncological outcomes in resections for rectal cancer.Material and Methods: Between January 2010 and December 2014, patients with rectal tumors were analyzed retrospectively. Demographic and pathological data and oncological outcomes were analyzed as disease-free survival, overall survival, and local recurrence.Results: A total of 158 patients' data were obtained. Median age was 60 (22-83). Fifty-three patients were older than 65 years of age (138). Ninety-five (60%) patients were males, and 63 (40%) were females. Eighty patients (50.4%) had middle rectal, and 78 (49.6) patients had lower rectal cancer. There was no effect of tumor localization on oncological outcomes. Univariate analyses revealed the effects of age (p= 0.003), operation type (p< 0.001), nodal status (p< 0.001), malignant lymph node ratio (p< 0.001), stage of the disease (p< 0.001), distal resection margin (p= 0.047), perineural invasion (p< 0.001), lymphatic invasion (p< 0.001), venous-vascular invasion (p= 0.025), local recurrence (p< 0.001) and distant metastasis (p< 0.001) on overall survival rates. Univariate analyses revealed the effects of nodal status (p= 0.007), malignant lymph node ratio (p= 0.005), stage of the disease (p= 0.008), perineural invasion (p= 0.004) and venous-vascular invasion (p< 0.001) on disease-free survival rates. Univariate analyses revealed the effects of anastomotic leak (p= 0.015) and venous-vascular invasion (p= 0.001) on local recurrence rates.Conclusion: Older age, advanced nodal status, and distant metastasis were detected as independent risk factors for overall survival. Perineural and venous-vascular invasion were detected as independent risk factors for disease-free survival. Lastly, anastomotic leak and venous-vascular invasion were detected as independent risk factors for local recurrence.
dc.identifier.doi10.47717/turkjsurg.2023.5946
dc.identifier.endpage203
dc.identifier.issn2564-6850
dc.identifier.issue3
dc.identifier.startpage197
dc.identifier.urihttps://doi.org/10.47717/turkjsurg.2023.5946
dc.identifier.urihttps://turkjsurg.com/full-text/1920/eng
dc.identifier.urihttps://hdl.handle.net/11452/45450
dc.identifier.volume39
dc.identifier.wos001083560100004
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherTurkish Surgical Assoc
dc.relation.journalTurkish Journal of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectTotal mesorectal excision
dc.subjectColorectal-cancer
dc.subjectPreoperative radiotherapy
dc.subjectAnastomotic leak
dc.subjectFollow-up
dc.subjectSurvival
dc.subjectInvasion
dc.subjectRatio
dc.subjectRectal cancer
dc.subjectRectal surgery
dc.subjectSurvival
dc.subjectLocal recurrence
dc.subjectSurgery
dc.titleRisk factors affecting oncological outcomes of surgical resections for middle and lower rectal cancer
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication987822b1-5f83-4c61-8d28-24da04a98bc6
relation.isAuthorOfPublicationbc7af80e-28da-4133-b35f-891a748753cb
relation.isAuthorOfPublication.latestForDiscovery987822b1-5f83-4c61-8d28-24da04a98bc6

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