Publication: Risk factors affecting oncological outcomes of surgical resections for middle and lower rectal cancer
dc.contributor.author | Tırnova, İsmail | |
dc.contributor.author | Işık, Özgen | |
dc.contributor.author | Yılmazlar, Ahmet Tuncay | |
dc.contributor.buuauthor | Tırnova, İsmail | |
dc.contributor.buuauthor | IŞIK, ÖZGEN | |
dc.contributor.buuauthor | YILMAZLAR, AHMET TUNCAY | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Genel Cerrahi Anabilim Dalı/Kolorektal Cerrahi Bilim Dalı. | |
dc.contributor.orcid | 0000-0003-4488-1607 | |
dc.contributor.orcid | 0000-0002-9541-5035 | |
dc.contributor.researcherid | AAW-9602-2020 | |
dc.contributor.researcherid | ISB-9235-2023 | |
dc.contributor.researcherid | T-7494-2017 | |
dc.contributor.researcherid | JOH-0415-2023 | |
dc.date.accessioned | 2024-09-30T05:46:43Z | |
dc.date.available | 2024-09-30T05:46:43Z | |
dc.date.issued | 2023-09-01 | |
dc.description.abstract | Objective: In our study, it was aimed to evaluate the factors affecting oncological outcomes in resections for rectal cancer.Material and Methods: Between January 2010 and December 2014, patients with rectal tumors were analyzed retrospectively. Demographic and pathological data and oncological outcomes were analyzed as disease-free survival, overall survival, and local recurrence.Results: A total of 158 patients' data were obtained. Median age was 60 (22-83). Fifty-three patients were older than 65 years of age (138). Ninety-five (60%) patients were males, and 63 (40%) were females. Eighty patients (50.4%) had middle rectal, and 78 (49.6) patients had lower rectal cancer. There was no effect of tumor localization on oncological outcomes. Univariate analyses revealed the effects of age (p= 0.003), operation type (p< 0.001), nodal status (p< 0.001), malignant lymph node ratio (p< 0.001), stage of the disease (p< 0.001), distal resection margin (p= 0.047), perineural invasion (p< 0.001), lymphatic invasion (p< 0.001), venous-vascular invasion (p= 0.025), local recurrence (p< 0.001) and distant metastasis (p< 0.001) on overall survival rates. Univariate analyses revealed the effects of nodal status (p= 0.007), malignant lymph node ratio (p= 0.005), stage of the disease (p= 0.008), perineural invasion (p= 0.004) and venous-vascular invasion (p< 0.001) on disease-free survival rates. Univariate analyses revealed the effects of anastomotic leak (p= 0.015) and venous-vascular invasion (p= 0.001) on local recurrence rates.Conclusion: Older age, advanced nodal status, and distant metastasis were detected as independent risk factors for overall survival. Perineural and venous-vascular invasion were detected as independent risk factors for disease-free survival. Lastly, anastomotic leak and venous-vascular invasion were detected as independent risk factors for local recurrence. | |
dc.identifier.doi | 10.47717/turkjsurg.2023.5946 | |
dc.identifier.endpage | 203 | |
dc.identifier.issn | 2564-6850 | |
dc.identifier.issue | 3 | |
dc.identifier.startpage | 197 | |
dc.identifier.uri | https://doi.org/10.47717/turkjsurg.2023.5946 | |
dc.identifier.uri | https://turkjsurg.com/full-text/1920/eng | |
dc.identifier.uri | https://hdl.handle.net/11452/45450 | |
dc.identifier.volume | 39 | |
dc.identifier.wos | 001083560100004 | |
dc.indexed.wos | WOS.ESCI | |
dc.language.iso | en | |
dc.publisher | Turkish Surgical Assoc | |
dc.relation.journal | Turkish Journal of Surgery | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Total mesorectal excision | |
dc.subject | Colorectal-cancer | |
dc.subject | Preoperative radiotherapy | |
dc.subject | Anastomotic leak | |
dc.subject | Follow-up | |
dc.subject | Survival | |
dc.subject | Invasion | |
dc.subject | Ratio | |
dc.subject | Rectal cancer | |
dc.subject | Rectal surgery | |
dc.subject | Survival | |
dc.subject | Local recurrence | |
dc.subject | Surgery | |
dc.title | Risk factors affecting oncological outcomes of surgical resections for middle and lower rectal cancer | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 987822b1-5f83-4c61-8d28-24da04a98bc6 | |
relation.isAuthorOfPublication | bc7af80e-28da-4133-b35f-891a748753cb | |
relation.isAuthorOfPublication.latestForDiscovery | 987822b1-5f83-4c61-8d28-24da04a98bc6 |
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