Publication:
Serum brain-derived neurotrophic factor, vascular endothelial growth factor and leptin levels in patients with a diagnosis of severe major depressive disorder with melancholic features

dc.contributor.authorKotan, Zeynep
dc.contributor.authorSarandöl, Emre
dc.contributor.authorKırhan, Emine
dc.contributor.authorÖzkaya, Güven
dc.contributor.authorKırlı, Selçuk
dc.contributor.buuauthorSARANDÖL, EMRE
dc.contributor.buuauthorKırhan, Emine
dc.contributor.buuauthorÖZKAYA, GÜVEN
dc.contributor.buuauthorKIRLI, SELÇUK
dc.contributor.departmentUludağ Üniversite/Tıp Fakültesi/Biyokimya Anabilim Dalı.
dc.contributor.departmentUludağ Üniversite/Tıp Fakültesi/Biyoistatistik Anabilim Dalı.
dc.contributor.departmentUludağ Üniversite/Tıp Fakültesi/Psikiyatri Anabilim Dalı.
dc.contributor.orcid0000-0003-0297-846X
dc.contributor.researcheridA-4421-2016
dc.contributor.researcheridABE-1716-2020
dc.contributor.researcheridDBC-8927-2022
dc.contributor.researcheridCZU-1387-2022
dc.date.accessioned2024-09-30T12:07:54Z
dc.date.available2024-09-30T12:07:54Z
dc.date.issued2012-04-01
dc.description.abstractObjective: Brain-derived neurotrophic factor (BDNF), vascular endothelial growth factor (VEGF) and leptin have been hypothesized to be involved in the neurobiology of depression. The aim of this study was to investigate BDNF, VEGF and leptin levels in patients with severe melancholic depression. Methods: A total of 40 drug-free patients with major depressive disorder (MDD) with melancholic features and 40 healthy controls were included in the study. Demographic information, psychiatric evaluation and physical examination were documented for both groups. Serum BDNF, VEGF levels were determined by enzyme-linked immunosorbent assay and leptin with radioimmunoassay methods. The Hamilton Depression Rating Scale and Hamilton Anxiety Rating Scale were applied to the patients. Results: There were no significant differences in serum BDNF, VEGF and leptin levels between the patient and control groups. There was a negative correlation between BDNF levels and the number of depressive episodes. It was noted that VEGF levels decreased with increasing severity of depression. Conclusions: These findings suggest that BDNF levels might be associated with the recurrence of depression and VEGF levels might be a determinant of the severity of depression.
dc.identifier.doi10.1177/2045125312436572
dc.identifier.endpage74
dc.identifier.issn2045-1253
dc.identifier.issue2
dc.identifier.startpage65
dc.identifier.urihttps://doi.org/10.1177/2045125312436572
dc.identifier.urihttps://journals.sagepub.com/doi/10.1177/2045125312436572
dc.identifier.urihttps://hdl.handle.net/11452/45520
dc.identifier.volume2
dc.identifier.wos000218952400004
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherSage Publications Ltd
dc.relation.bap2008/37
dc.relation.journalTherapeutic Advances in Psychopharmacology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectFactor bdnf
dc.subjectPlasma leptin
dc.subjectCortisol secretion
dc.subjectStress system
dc.subjectWomen
dc.subjectGene
dc.subjectFluoxetine
dc.subjectExpression
dc.subjectReceptor
dc.subjectWeight
dc.subjectBrain-derived neurotrophic factor
dc.subjectDepression
dc.subjectLeptin
dc.subjectVascular endothelial growth factor
dc.subjectPharmacology & pharmacy
dc.subjectPsychiatry
dc.titleSerum brain-derived neurotrophic factor, vascular endothelial growth factor and leptin levels in patients with a diagnosis of severe major depressive disorder with melancholic features
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication9529fb52-20cd-4fb3-9767-19121683aa62
relation.isAuthorOfPublication648e85b9-2f4f-4f92-a2d7-794286abd0fd
relation.isAuthorOfPublicationd1ab1da7-b6f7-4246-93a5-2d26aef85c46
relation.isAuthorOfPublication.latestForDiscovery9529fb52-20cd-4fb3-9767-19121683aa62

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