Publication:
Investigation of anti-cancer activity of newly synthesized 2,4-pentadien-1-one derivative containing benzofuran in human lung and colon cancer cells

dc.contributor.authorCoşkun, Demet
dc.contributor.buuauthorArı, Ferda
dc.contributor.buuauthorARI, FERDA
dc.contributor.buuauthorTuna, Gonca
dc.contributor.buuauthorErtürk, Elif
dc.contributor.buuauthorERTÜRK, ELİF
dc.contributor.departmentBursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Biyoloji Bölümü.
dc.contributor.orcid0000-0001-7141-6909
dc.contributor.orcid0000-0002-6729-7908
dc.contributor.researcheridAAG-7012-2021
dc.contributor.researcheridIWM-5784-2023
dc.date.accessioned2024-10-30T12:48:30Z
dc.date.available2024-10-30T12:48:30Z
dc.date.issued2023-01-01
dc.description.abstractObjectives: A member of the flavonoid family, chalcones are natural compounds known to have anticancer effects. Chalcones and their synthetic derivatives have become an important field of interest for cancer research. In this study, we aimed to investigate the anticancer activity of a new Chalcone derivative compound [(2E,4E)-1-(7-ethoxy-1-benzofuran-2-yl)-5-(4-hydroxy-3-methoxyphenyl)penta-2,4-dien-1-one] synthesized by the Claisen-Schmidt reaction based on the curcumin structure in human lung (A549, H1299) and colon cancer (HCT116, HT29) cells. Methods: The effect of Chalcone compound on cell viability was evaluated with the SRB test. In addition, combination studies with 5-FU, which is used as a chemotherapy drug, was performed. The cell death mode was determined by fluorescence imaging method with Hoechst 33342, Annexin-V-FITC and Propidium iodide (PI) triple staining. Results: IC50 values of the Chalcone compound were found as 2.85, 1.46, 0.59, 0.35 mu M for A549, H1299, HCT116, HT29, respectively. As a result of fluorescence imaging, pycnotic nuclei and chromatin condensation were observed in the cells in addition to positive staining with Annexin-V-FITC (green). Conclusion: The results showed that the newly synthesized Chalcone derivative compound has a significant cytotoxic effect on cancer cells and induce apoptosis.
dc.identifier.doi10.14744/ejmo.2023.61594
dc.identifier.endpage33
dc.identifier.issue1
dc.identifier.startpage24
dc.identifier.urihttps://doi.org/10.14744/ejmo.2023.61594
dc.identifier.urihttps://hdl.handle.net/11452/47205
dc.identifier.volume7
dc.identifier.wos001135809500009
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherKare Publ
dc.relation.bapTHIZ-2021-457
dc.relation.journalEurasian Journal Of Medicine And Oncology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectChalcone derivatives
dc.subjectDiarylpentanoid analogs
dc.subjectBiological evaluation
dc.subjectProstate-cancer
dc.subjectCurcumin
dc.subjectApoptosis
dc.subjectDeath
dc.subjectRos
dc.subjectIsoliquiritigenin
dc.subjectAntioxidant
dc.subjectApoptosis
dc.subjectChalcones
dc.subjectNeoplasms
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectMedicine, general & internal
dc.subjectOncology
dc.subjectGeneral & internal medicine
dc.titleInvestigation of anti-cancer activity of newly synthesized 2,4-pentadien-1-one derivative containing benzofuran in human lung and colon cancer cells
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication1dd517bb-3e11-411e-a8db-27d448dcd55e
relation.isAuthorOfPublication54fbb8ee-6806-4d77-9430-9b360d81a2ab
relation.isAuthorOfPublication.latestForDiscovery1dd517bb-3e11-411e-a8db-27d448dcd55e

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