Publication:
Antinociceptive effect of chlorogenic acid in rats with painful diabetic neuropathy

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dc.contributor.buuauthorBağdaş, Deniz
dc.contributor.buuauthorÖzbölük, Hasret Yücel
dc.contributor.buuauthorÇinkılıç, Nilüfer
dc.contributor.buuauthorGürün, Mine Sibel
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentBiyoloji Bölümü
dc.contributor.departmentTıbbi Farmakoloji Ana Bilim Dalı
dc.contributor.departmentDeney Hayvanları Yetiştirme ve Araştırma Birimi
dc.contributor.orcid0000-0002-3595-6286
dc.contributor.researcheridAAG-8716-2019
dc.contributor.researcheridAAH-5296-2021
dc.contributor.scopusid15062425700
dc.contributor.scopusid55890590200
dc.contributor.scopusid26533892300
dc.contributor.scopusid55664349700
dc.date.accessioned2022-08-16T07:14:17Z
dc.date.available2022-08-16T07:14:17Z
dc.date.issued2014-06
dc.description.abstractThe present study aimed to evaluate possible antinociceptive effects of chlorogenic acid in streptozotocin-induced diabetic neuropathic pain in rats. Chlorogenic acid (100 mg/kg) was administered daily for 14 days. Our study showed for the first time that both single and chronic chlorogenic acid treatments produced significant antinociceptive effects in diabetic rats. In contrast, single dose of chlorogenic acid showed no signs of an antinociceptive effect, but chronic treatment exerted antinociceptive potential in nondiabetic rats. Additionally, chronic treatment effectively reduced hyperglycemia that induced by diabetes. In conclusion, chlorogenic acid has beneficial effects for the management of diabetic neuropathic pain.
dc.identifier.citationBağdaş, D. vd. (2014). "Antinociceptive effect of chlorogenic acid in rats with painful diabetic neuropathy". Journal of Medicinal Food, 17(6), 730-732.
dc.identifier.endpage732
dc.identifier.issn1096-620X
dc.identifier.issn1557-7600
dc.identifier.issue6
dc.identifier.pubmed24611441
dc.identifier.scopus2-s2.0-84902441455
dc.identifier.startpage730
dc.identifier.urihttps://doi.org/10.1089/jmf.2013.2966
dc.identifier.urihttps://www.liebertpub.com/doi/10.1089/jmf.2013.2966?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed
dc.identifier.urihttp://hdl.handle.net/11452/28192
dc.identifier.volume17
dc.identifier.wos000337903500014
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherMary Ann Liebert
dc.relation.journalJournal of Medicinal Food
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectAntihyperalgesic
dc.subjectAntinociceptive
dc.subjectChlorogenic acid
dc.subjectDiabetes
dc.subjectDiabetic neuropathy
dc.subjectPain
dc.subjectPharmacology & pharmacy
dc.subjectFood science & technology
dc.subjectNutrition & dietetics
dc.subject.emtreeChlorogenic acid
dc.subject.emtreeGlucose
dc.subject.emtreeAnalgesic agent
dc.subject.emtreeAntidiabetic agent
dc.subject.emtreeChlorogenic acid
dc.subject.emtreePlant extract
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAntidiabetic activity
dc.subject.emtreeAntinociception
dc.subject.emtreeArticle
dc.subject.emtreeControlled study
dc.subject.emtreeGlucose blood level
dc.subject.emtreeHyperalgesia
dc.subject.emtreeHyperglycemia
dc.subject.emtreeLong term care
dc.subject.emtreeNeuropathic pain
dc.subject.emtreeNonhuman
dc.subject.emtreePriority journal
dc.subject.emtreeRat
dc.subject.emtreeSingle drug dose
dc.subject.emtreeStreptozotocin-induced diabetic neuropathy
dc.subject.emtreeTreatment duration
dc.subject.emtreeAnimal
dc.subject.emtreeComplication
dc.subject.emtreeDiabetic neuropathies
dc.subject.emtreeExperimental diabetes mellitus
dc.subject.emtreeMale
dc.subject.emtreePhytotherapy
dc.subject.emtreeWistar rat
dc.subject.meshAnalgesics
dc.subject.meshAnimals
dc.subject.meshChlorogenic acid
dc.subject.meshDiabetes mellitus, experimental
dc.subject.meshDiabetic neuropathies
dc.subject.meshHyperglycemia
dc.subject.meshHypoglycemic agents
dc.subject.meshMale
dc.subject.meshPhytotherapy
dc.subject.meshPlant extracts
dc.subject.meshRats, wistar
dc.subject.scopusAntioxidant; Carlina Oxide; Lonicera
dc.subject.wosChemistry, medicinal
dc.subject.wosFood science & technology
dc.subject.wosNutrition & dietetics
dc.titleAntinociceptive effect of chlorogenic acid in rats with painful diabetic neuropathy
dc.typeArticle
dc.wos.quartileQ3 (Chemistry, medicinal)
dc.wos.quartileQ2 (Food science & technology)
dc.wos.quartileQ4 (Nutrition & dietetics)
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Deney Hayvanları Yetiştirme ve Araştırma Birimi
local.contributor.departmentTıp Fakültesi/Tıbbi Farmakoloji Ana Bilim Dalı
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Bölümü
local.indexed.atScopus
local.indexed.atWOS

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