Publication: Arterial elasticity and plasma levels of adiponectin and leptin in type 2 diabetic patients treated with thiazolidinediones
dc.contributor.author | Öz, Özen | |
dc.contributor.author | Tuncel, Ercan | |
dc.contributor.author | Eryılmaz, Salih | |
dc.contributor.author | Fazlıoğlu, Murat | |
dc.contributor.author | Gül, Cuma Bülent | |
dc.contributor.author | Ersoy, Canan | |
dc.contributor.author | Ocak, Nihal | |
dc.contributor.author | Dirican, Melahat | |
dc.contributor.author | Cangür, Şengül | |
dc.contributor.author | Baran, İbrahim | |
dc.contributor.author | İmamoğlu, Sazı | |
dc.contributor.buuauthor | ÖZ GÜL, ÖZEN | |
dc.contributor.buuauthor | Tuncel, Ercan | |
dc.contributor.buuauthor | Eryılmaz, Salih | |
dc.contributor.buuauthor | Fazlıoğlu, Murat | |
dc.contributor.buuauthor | GÜL, CUMA BÜLENT | |
dc.contributor.buuauthor | ERSOY, CANAN | |
dc.contributor.buuauthor | Ocak, Nihal | |
dc.contributor.buuauthor | Dirican, Melahat | |
dc.contributor.buuauthor | Cangür, Şengül | |
dc.contributor.buuauthor | Baran, İbrahim | |
dc.contributor.buuauthor | İmamoğlu, Sazı | |
dc.contributor.department | Tıp Fakültesi | |
dc.contributor.department | Kardiyoloji Ana Bilim Dalı | |
dc.contributor.orcid | 0000-0003-2467-9356 | |
dc.contributor.researcherid | AAH-8861-2021 | |
dc.contributor.researcherid | AAG-6985-2021 | |
dc.contributor.researcherid | A-7063-2018 | |
dc.contributor.researcherid | DKQ-6967-2022 | |
dc.contributor.researcherid | EBN-7188-2022 | |
dc.contributor.researcherid | EVM-4069-2022 | |
dc.contributor.researcherid | EXM-4051-2022 | |
dc.contributor.researcherid | A-7063-2018 | |
dc.contributor.researcherid | FOJ-8942-2022 | |
dc.contributor.researcherid | ESK-6562-2022 | |
dc.contributor.researcherid | CHY-1092-2022 | |
dc.contributor.researcherid | CDA-1396-2022 | |
dc.date.accessioned | 2024-11-26T07:18:33Z | |
dc.date.available | 2024-11-26T07:18:33Z | |
dc.date.issued | 2008-04-01 | |
dc.description.abstract | Background Thiazolidinediones (TZDs) improve peripheral insulin sensitivity, but the effect on arterial stiffness is less clear. The aim of the present study was to assess the differential effect of pioglitazone or rosiglitazone on arterial stiffness and plasma levels of adiponectin and leptin in patients with type 2 diabetes mellitus. Methods Thirty-five type 2 diabetic subjects were randomly assigned to receive pioglitazone (30 mg/day; n = 14), rosiglitazone (4 mg/day; n = 11), or placebo (medical nutrition therapy; n = 10) for 12 weeks. Changes in plasma glucose, glycosylated hemoglobin, insulin resistance (HOMA-IR), total cholesterol, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, triglycerides, adiponectin, and leptin were evaluated at baseline and after 12 weeks. In parallel, large arterial compliance (C1) and small arterial compliance (C2) were measured at baseline and at the end of treatment period. Results At 12 weeks, the rosiglitazone (P = 0.026) and pioglitazone (P = 0.004) groups had a significant increase from baseline in adiponectin that was not seen in the medical nutrition therapy group. No significant changes in plasma leptin and in C1 and C2 elasticity indexes were observed over the entire study period in any of the treatment groups. Conclusions In this study of patients with type 2 diabetes, treatment with TZDs was associated with a significant improvement in adiponectin levels, although no significant effects were seen on leptin levels and arterial elasticity. | |
dc.identifier.doi | 10.1007/s12020-008-9058-x | |
dc.identifier.endpage | 105 | |
dc.identifier.issn | 0969-711X | |
dc.identifier.issue | 1 | |
dc.identifier.startpage | 101 | |
dc.identifier.uri | https://doi.org/10.1007/s12020-008-9058-x | |
dc.identifier.uri | https://link.springer.com/article/10.1007/s12020-008-9058-x | |
dc.identifier.uri | https://hdl.handle.net/11452/48492 | |
dc.identifier.volume | 33 | |
dc.identifier.wos | 000255537800013 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Humana Press Inc | |
dc.relation.journal | Endocrine | |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi | |
dc.rights | info:eu-repo/semantics/closedAccess | |
dc.subject | Necrosis-factor-alpha | |
dc.subject | Peroxisome-proliferator | |
dc.subject | Metabolic syndrome | |
dc.subject | Adipose-tissue | |
dc.subject | Cardiovascular-disease | |
dc.subject | Insulin-resistance | |
dc.subject | Gamma agonist | |
dc.subject | Stiffness | |
dc.subject | Rosiglitazone | |
dc.subject | Pioglitazone | |
dc.subject | Thiazolidinediones | |
dc.subject | Diabetes mellitus type 2 | |
dc.subject | Adipokines | |
dc.subject | Arterial elasticity | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Endocrinology & metabolism | |
dc.title | Arterial elasticity and plasma levels of adiponectin and leptin in type 2 diabetic patients treated with thiazolidinediones | |
dc.type | Article | |
dspace.entity.type | Publication | |
local.contributor.department | Tıp Fakültesi/İç Hastalıkları Ana Bilim Dalı | |
local.contributor.department | Tıp Fakültesi/Endokrinoloji ve Metabolizma Ana Bilim Dalı | |
local.contributor.department | Tıp Fakültesi/Kardiyoloji Ana Bilim Dalı | |
local.contributor.department | Tıp Fakültesi/Biyokimya Ana Bilim Dalı | |
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