Publication:
Exploring the anthelmintic activity of Olea europaea L (Olive) leaves extract and oleuropein in mice naturally infected with Aspiculuris tetraptera

dc.contributor.authorKamran, Muhammad Adeel
dc.contributor.authorYIldIrımhan, Hikmet Sami
dc.contributor.authorŞenlik, Bayram
dc.contributor.buuauthorKamran, Muhammad Adeel
dc.contributor.buuauthorYILDIRIMHAN, HİKMET SAMİ
dc.contributor.buuauthorŞENLİK, BAYRAM
dc.contributor.departmentUludağ Üniversitesi/Fen-Edebiyat Fakültesi/Biyoloji Bölümü
dc.contributor.departmentUludağ Üniversitesi/Veteriner Bilimleri Fakültesi/Parazitoloji Anabilim Dalı
dc.contributor.orcid0000-0003-2964-2245
dc.contributor.researcheridAFN-9439-2022
dc.contributor.researcheridAAC-1581-2020
dc.contributor.researcheridGBN-0139-2022
dc.date.accessioned2024-10-01T12:22:55Z
dc.date.available2024-10-01T12:22:55Z
dc.date.issued2023-09-01
dc.description.abstractOxyuriasis, caused by the nematode Enterobius vermicularis, is one of the cosmopolitan intestinal infections of humans. Aspiculuris tetraptera commonly infects mice and it is morphologically similar to E. vermicularis. Parasitic resistance reduces the efficiency of synthetic drugs and poses economic impacts on the dairy sector, thus necessitating novel anthelmintic agents. Olea europaea L. (Olive) is a bioactive plant with potent pharmacological activities. However, its effects on oxyurids are poorly known, and no studies are currently exploring olives' anthelmintic potential. In this study, we investigated the pharmacokinetic behaviors of O. europaea leaves extract (OLE) and its phenolic compound oleuropein in mice infected with A. tetraptera, in comparison with Albendazole (ABZ), a standard drug used to treat parasitic worms. Fecal flotation method was used to identify the infestation with A. tetraptera eggs by examining the stool samples from mice. Infected animals were divided into 7 groups. 250 mg/kg, 500 mg/kg, and 1000 mg/kg doses of OLE, 5 mg/kg and 20 mg/kg doses of oleuropein, 10 mg/kg of ABZ and tap water were orally administered by gavage for 7 days during treatments. Drug efficacies and statistical differences between the treatments and controls were evaluated. Our results revealed 92.43 % efficacy of ABZ, similar to 92.19 % efficacy of 1000 mg/kg of OLE. At the same time, 250 mg/kg and 500 mg/kg concentrations of OLE remained 70.03 % and 63.18 % effective in reducing worm counts. Efficacy percentages of 5 mg/kg and 20 mg/kg of oleuropein were 9.27 % and 70.56 %, respectively. Statistical analysis of ABZ was significant compared to 1000 mg/kg of OLE, which was almost equal but insignificant. In general, our results confirm the anthelmintic potential of OLE and oleuropein against mice pinworms and open the way for targeted extraction of bioactive compounds from plants to optimize its use in human and veterinary medicine.
dc.identifier.doi10.2478/helm-2023-0025
dc.identifier.eissn1336-9083
dc.identifier.endpage245
dc.identifier.issn0440-6605
dc.identifier.issue3
dc.identifier.startpage240
dc.identifier.urihttps://doi.org/10.2478/helm-2023-0025
dc.identifier.urihttps://sciendo.com/article/10.2478/helm-2023-0025
dc.identifier.urihttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC10750239/
dc.identifier.urihttps://hdl.handle.net/11452/45602
dc.identifier.volume60
dc.identifier.wos001135610400008
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherSciendo
dc.relation.bapFGA-2021-191
dc.relation.journalHelminthologia
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectConstituent
dc.subjectOlea europaea
dc.subjectOleuropein
dc.subjectAspiculuris tetraptera
dc.subjectAnthelmintic effect
dc.subjectOlive leaves extract
dc.subjectAlbendazole
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectParasitology
dc.subjectZoology
dc.titleExploring the anthelmintic activity of Olea europaea L (Olive) leaves extract and oleuropein in mice naturally infected with Aspiculuris tetraptera
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationc462dacb-ec10-443e-a640-8cef2f8e3277
relation.isAuthorOfPublicatione626aa13-7feb-4000-b304-87312f34b1d9
relation.isAuthorOfPublication.latestForDiscoveryc462dacb-ec10-443e-a640-8cef2f8e3277

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