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Targeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetrac

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dc.contributor.authorSudha, Thangirala
dc.contributor.authorBharali, Dhruba J
dc.contributor.authorDarwish, Noureldien H.E.
dc.contributor.authorKeating, Kelly A
dc.contributor.authorLin, Hung-Yun
dc.contributor.authorDavis, Paul J.
dc.contributor.authorMousa, Shaker A
dc.contributor.buuauthorYalçın, Murat
dc.contributor.buuauthorCoşkun, Melis Debreli
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentFen Edebiyat Fakültesi
dc.contributor.departmentBiyoloji Bölümü
dc.contributor.departmentFizyoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-5600-8162
dc.contributor.researcheridAAG-6956-2021
dc.contributor.researcheridAAF-3992-2020
dc.contributor.scopusid57192959734
dc.contributor.scopusid57193066146
dc.date.accessioned2022-11-04T06:26:08Z
dc.date.available2022-11-04T06:26:08Z
dc.date.issued2017-02
dc.description.abstractAim: Nano-diamino-tetrac (NDAT) targets a receptor on integrin alpha v beta 3; alpha v beta 3 is generously expressed by cancer cells and dividing endothelial cells and to a small extent by nonmalignant cells. The tetrac (tetraiodothyroacetic acid) of NDAT is covalently bound to a poly(lactic-co-glycolic acid) nanoparticle that encapsulates anticancer drugs. We report NDAT delivery efficiency of cisplatin to agent-susceptible urinary bladder cancer xenografts. Materials & methods: Cisplatin-loaded NDAT (NDAT-cisplatin) was administered to xenograft-bearing nude mice. Tumor size response and drug content were measured. Results: Intratumoral drug concentration was up to fivefold higher (p < 0.001) in NDAT-cisplatin-exposed lesions than with conventional systemic administration. Tumor volume reduction achieved was NDAT-cisplatin > NDAT without cisplatin > cisplatin alone. Conclusion: NDAT markedly enhances cisplatin delivery to urinary bladder cancer xenografts and increases drug efficacy.
dc.description.sponsorshipNanoPharmaceuticals LLC (NY, USA)
dc.description.sponsorshipNanoPharmaceuticals LLC
dc.identifier.citationSudha, T. vd. (2017). ''Targeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetrac''. Nanomedicine, 12(3), 195-205.
dc.identifier.endpage205
dc.identifier.issn1743-5889
dc.identifier.issn1748-6963
dc.identifier.issue3
dc.identifier.pubmed28102776
dc.identifier.scopus2-s2.0-85010383217
dc.identifier.startpage195
dc.identifier.urihttps://doi.org/10.2217/nnm-2016-0315
dc.identifier.urihttps://www.futuremedicine.com/doi/10.2217/nnm-2016-0315
dc.identifier.urihttp://hdl.handle.net/11452/29376
dc.identifier.volume12
dc.identifier.wos000395674900006
dc.indexed.wosSCIE
dc.language.isoen
dc.publisherFuture Medicine
dc.relation.collaborationYurt dışı
dc.relation.journalNanomedicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectBiotechnology & applied microbiology
dc.subjectScience & technology - other topics
dc.subjectCisplatin
dc.subjectIntegrin
dc.subjectNanotetrac
dc.subjectNDAT
dc.subjectTetraiodothyroacetic acid
dc.subjectUrinary bladder carcinoma
dc.subjectActivated protein-kinase
dc.subjectTetraiodothyroacetic acid
dc.subjectThyroid-hormone
dc.subjectCancer-cells
dc.subjectPlatinum
dc.subjectIntegrin
dc.subjectReceptor
dc.subjectGrowth
dc.subjectDrugs
dc.subject.emtreeAcetic acid derivative
dc.subject.emtreeCisplatin
dc.subject.emtreeNanocarrier
dc.subject.emtreeNanodiaminotetrac
dc.subject.emtreeNanoparticle
dc.subject.emtreePolyglactin
dc.subject.emtreeTetraiodothyroacetic acid
dc.subject.emtreeUnclassified drug
dc.subject.emtreeAntineoplastic agent
dc.subject.emtreeLactic acid
dc.subject.emtreePolyglycolic acid
dc.subject.emtreePolylactic acid-polyglycolic acid copolymer
dc.subject.emtreeVitronectin receptor
dc.subject.emtreeAnimal experiment
dc.subject.emtreeAnimal model
dc.subject.emtreeAnimal tissue
dc.subject.emtreeArticle
dc.subject.emtreeBladder cancer
dc.subject.emtreeCancer size
dc.subject.emtreeControlled study
dc.subject.emtreeCovalent bond
dc.subject.emtreeDrug delivery system
dc.subject.emtreeDrug dosage form comparison
dc.subject.emtreeDrug efficacy
dc.subject.emtreeDrug response
dc.subject.emtreeDrug tissue level
dc.subject.emtreeFemale
dc.subject.emtreeHuman
dc.subject.emtreeHuman cell
dc.subject.emtreeMouse
dc.subject.emtreeNanoencapsulation
dc.subject.emtreeNonhuman
dc.subject.emtreeTumor xenograft
dc.subject.emtreeAnimal
dc.subject.emtreeBladder tumor
dc.subject.emtreeCancer transplantation
dc.subject.emtreeCell culture technique
dc.subject.emtreeCell survival
dc.subject.emtreeChemistry
dc.subject.emtreeDrug delivery system
dc.subject.emtreeDrug release
dc.subject.emtreeMetabolism
dc.subject.emtreeNude mouse
dc.subject.emtreeParticle size
dc.subject.emtreeSurface property
dc.subject.emtreeTumor cell line
dc.subject.emtreeXenograft
dc.subject.emtreeCisplatin
dc.subject.meshAnimals
dc.subject.meshAntineoplastic agents
dc.subject.meshCell culture techniques
dc.subject.meshCell line
dc.subject.meshTumor
dc.subject.meshCell survival
dc.subject.meshCisplatin
dc.subject.meshDrug delivery systems
dc.subject.meshDrug liberation
dc.subject.meshFemale
dc.subject.meshHeterografts
dc.subject.meshHumans
dc.subject.meshIntegrin alphabeta3
dc.subject.meshLactic acid
dc.subject.meshMice, nude
dc.subject.meshNanoparticles
dc.subject.meshNeoplasm transplantation
dc.subject.meshParticle size
dc.subject.meshPolyglycolic acid
dc.subject.meshSurface properties
dc.subject.meshUrinary bladder neoplasms
dc.subject.scopusIntegrin; Thyroid Hormones; Nano-Diamino-Tetrac
dc.subject.wosBiotechnology & applied microbiology
dc.subject.wosNanoscience & nanotechnology
dc.titleTargeted delivery of cisplatin to tumor xenografts via the nanoparticle component of nano-diamino-tetrac
dc.typeArticle
dc.wos.quartileQ1 (Biotechnology & applied microbiology)
dc.wos.quartileQ2 (Nanoscience & nanotechnology)
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi/Fizyoloji Ana Bilim Dalı
local.contributor.departmentFen Edebiyat Fakültesi/Biyoloji Bölümü
local.indexed.atScopus
local.indexed.atWOS

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