Publication:
The effect of enteral glutamine on hepatic regeneration, hepatic functions and bacterial translocation in rats following partial hepatectomy

dc.contributor.buuauthorKILIÇTURGAY, SADIK AYHAN
dc.contributor.buuauthorAktaş, Hikmet
dc.contributor.buuauthorKılıçturgay, A. Sadık
dc.contributor.buuauthorÖztürk, Ersin
dc.contributor.buuauthorŞehitoğlu, İbrahim
dc.contributor.buuauthorIşık, Özgen
dc.contributor.buuauthorIŞIK, ÖZGEN
dc.contributor.departmentTıp Fakültesi
dc.contributor.departmentPatoloji Ana Bilim Dalı
dc.contributor.orcid0000-0002-9541-5035
dc.contributor.researcheridAAW-9602-2020
dc.contributor.researcheridP-5779-2019
dc.contributor.researcheridABF-8955-2021
dc.date.accessioned2024-11-20T05:29:36Z
dc.date.available2024-11-20T05:29:36Z
dc.date.issued2010-09-01
dc.description.abstractPurpose: The effects of enteral glutamine on bacterial translocation and hepatic regeneration have been investigated in this study.Materials and Methods: Thirty female Wistar-Albino rats were divided into three groups: 1. Sham Group (n=10); laparotomy followed by liver exploration, was performed and then abdomen was closed. For the following 7 days, the rats were fed with standard food and water. 2. Control group (n=10); following 70% hepatectomy, the rats were fed with standard food and water for 7 days. 3. Trial group (n=10) following 70% hepatectomy, the rats were fed with standard food and water for 7 days and in addition with 0.5gr/kg/day glutamine via orogastric catheter. On the 7th day, the rats were sacrificed. Hepatic regeneration and enterocyte proliferation were evaluated by tissue Ki-67 immune-histochemistry. To evaluate the macroscopic hepatic growth rate, the wet weight of remnant liver tissue was measured. Serum AST/ALT were measured. Bacterial translocation was evaluated by blood samples taken from portal vein and, tissue samples from mesenteric lymph nodes, liver, spleen and lungs. Group values were compared using Kruskal- Wallis (for comparison of three groups) or Mann-Whitney U tests (for comparison of two groups). P<0,05 was accepted as significant.Results: Liver Ki-67 proliferation index (PI) showed significant difference between groups (p=0,001). It was higher in the trial group when compared with the control group (p<0,01). It was also higher in the control group when compared with the sham group (p<0,05). Small intestine Ki-67 PI was significantly higher in the trial group than other groups (p<0,01). The weight of remnant liver tissue was significantly higher in the trial group than in the control group (p<0,01). AST\ALT levels and bacterial translocation rates were comparable between groups.Conclusion: Positive effects of enteral glutamine supplementation on hepatic regeneration was observed. However, no effect was noted on liver functions or bacterial translocation.
dc.identifier.doi10.5097/1300-0705.UCD.601-10.01
dc.identifier.endpage135
dc.identifier.issn2564-6850
dc.identifier.issue3
dc.identifier.startpage129
dc.identifier.urihttps://doi.org/10.5097/1300-0705.UCD.601-10.01
dc.identifier.urihttps://hdl.handle.net/11452/48146
dc.identifier.volume26
dc.identifier.wos000420186700002
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherAves
dc.relation.journalTurkish Journal Of Surgery
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLiver regeneration
dc.subjectGlutamine
dc.subjectBacterial translocation
dc.subjectHepatic regeneration
dc.subjectHepatectomy
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectSurgery
dc.titleThe effect of enteral glutamine on hepatic regeneration, hepatic functions and bacterial translocation in rats following partial hepatectomy
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentTıp Fakültesi/Genel Cerrahi Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Patoloji Ana Bilim Dalı
relation.isAuthorOfPublicationc44cb84a-5b92-4f00-b59f-f1b243f1171c
relation.isAuthorOfPublication987822b1-5f83-4c61-8d28-24da04a98bc6
relation.isAuthorOfPublication.latestForDiscovery987822b1-5f83-4c61-8d28-24da04a98bc6

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