Publication:
Plants from northwestern anatolia display selective cytotoxicity and induce mitotic catastrophe: A study on anticancer and genotoxic activities

No Thumbnail Available

Date

2023-08-16

Journal Title

Journal ISSN

Volume Title

Publisher

Wiley

Research Projects

Organizational Units

Journal Issue

Abstract

Anatolia is rich in floristic diversity with a high rate of endemism. Eight plant species from northwestern Anatolia were evaluated for their anti-growth properties in two malignant (MCF-7 and MDA-MB-231) and a non-malignant (MCF-10A) breast cell lines. The two most active extracts, Achillea multifida (AME) and Astragalus sibthorpianus (ASE), induced apoptotic cell death in all cell lines. The major phenolic compounds in AME were identified as chlorogenic acid, and catechins in ASE. ASE displayed selective cytotoxicity against breast cancer cells, with DNA damage repair in non-malignant cells contributing to its selectivity. Conversely, AME induced DNA damage in a time-dependent manner and displayed a dual dose-dependent biological activity, resulting in mitotic catastrophe and apoptosis at different doses. Most plant species exhibited moderate to strong cytotoxicity, highlighting their medicinal and economic potential and the need for their protection.

Description

Keywords

Astragalus-membranaceus, Antioxidant capacity, Traditional medicine, Cell-death, Cancer, Antibacterial, Polyphenols, Flavonoids, Apoptosis, Extracts, Anticancer, Apoptosis, Cytotoxicity, Endemic plants, Genotoxicity, Science & technology, Life sciences & biomedicine, Physical sciences, Biochemistry & molecular biology, Chemistry, multidisciplinary, Chemistry

Citation

Collections


Metrikler

Search on Google Scholar


Total Views

1

Total Downloads

0