Publication:
Cytotoxic and genotoxic effects of an endemic plant of Turkey salvia kronenburgii on breast cancer cell lines

dc.contributor.authorÇebi, Ayşegül
dc.contributor.authorAkgün, Egemen
dc.contributor.authorÇelikler, Serap
dc.contributor.authorFırat, Mehmet
dc.contributor.authorÖzel, Mustafa Zafer
dc.contributor.authorUlukaya, Engin
dc.contributor.authorArı, Ferda
dc.contributor.buuauthorÇELİKLER KASIMOĞULLARI, SERAP
dc.contributor.buuauthorARI, FERDA
dc.contributor.departmentUludağ Üniversite/Fen Bilimleri Fakültesi/Biyoloji Fakültesi
dc.contributor.researcheridAAG-7012-2021
dc.contributor.researcheridJCD-5015-2023
dc.date.accessioned2024-10-14T13:13:17Z
dc.date.available2024-10-14T13:13:17Z
dc.date.issued2019-07-01
dc.description.abstractContext: The natural products derived from plants are the important sources that can be used for breast cancer treatment. Salvia species and their derived products were recommended as potential antitumor substances.Aim: The potential cytotoxic and genotoxic effects of Salvia kronenburgii have been investigated on breast cancer cell lines, MCF-7 and MDA-MB-231.Materials and Methods: Determination of chemical compounds of S. kronenburgii was done using a gas chromatography coupled to time-of-flight mass spectrometry system and a dual-stage commercial thermal desorption injector. Growth inhibition of the S. kronenburgii was measured by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide and ATP viability assays. The cell death mode was detected by fluorescent dyes. Genotoxic effect of S. kronenburgii was measured by comet assay.Results: S. kronenburgii showed antiproliferative effect in a dose-dependent manner on MCF-7 and MDA-MB-231 cell lines by inducing apoptosis-like cell death. The pyknotic cell nuclei were observed at the cell lines in response to S. kronenburgii. Furthermore, significant increase was shown in genetic damage index and frequencies in the damaged cells.Conclusion: S. kronenburgii might be a promising natural source for cancer therapy. Further experiments need to be done in vivo to understand of the anticancer effects of this plant.
dc.identifier.doi10.4103/jcrt.JCRT_1322_16
dc.identifier.eissn1998-4138
dc.identifier.eissnhttps://journals.lww.com/cancerjournal/fulltext/2019/15050/cytotoxic_and_genotoxic_effects_of_an_endemic.21.aspx
dc.identifier.endpage1086
dc.identifier.issn0973-1482
dc.identifier.issue5
dc.identifier.startpage1080
dc.identifier.urihttps://doi.org/10.4103/jcrt.JCRT_1322_16
dc.identifier.urihttps://hdl.handle.net/11452/46392
dc.identifier.volume15
dc.identifier.wos000503180500021
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.bapBUAP (F)-2014/3
dc.relation.journalJournal of Cancer Research and Therapeutics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAnticancer activity
dc.subjectGrowth-inhibition
dc.subjectTanshinone iia
dc.subjectDna-damage
dc.subjectApoptosis
dc.subjectOfficinalis
dc.subjectInduction
dc.subjectLamiaceae
dc.subjectExtract
dc.subjectComet
dc.subjectBreast cancer
dc.subjectCytotoxicity
dc.subjectGenotoxicity
dc.subjectIn vitro
dc.subjectSalvia kronenburgii
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectOncology
dc.titleCytotoxic and genotoxic effects of an endemic plant of Turkey salvia kronenburgii on breast cancer cell lines
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublicationd293a689-5b5d-4b75-84b7-ae61987b866a
relation.isAuthorOfPublication1dd517bb-3e11-411e-a8db-27d448dcd55e
relation.isAuthorOfPublication.latestForDiscoveryd293a689-5b5d-4b75-84b7-ae61987b866a

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