Publication: The expression and relationship of adipo R1/R2 in gastric intestinal metaplasia
dc.contributor.author | Ayyildiz, T. | |
dc.contributor.author | Erturk, B. | |
dc.contributor.buuauthor | Dolar, E. | |
dc.contributor.buuauthor | DOLAR, MAHMUT ENVER | |
dc.contributor.buuauthor | Ugras, N. | |
dc.contributor.buuauthor | UĞRAŞ, NESRİN | |
dc.contributor.buuauthor | Dizdar, O. S. | |
dc.contributor.buuauthor | Adim, S. B. | |
dc.contributor.buuauthor | Yerci, O. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı. | |
dc.contributor.department | Bursa Uludağ Üniversitesi/Tıp Fakültesi/Gastroentoloji Anabilim Dalı. | |
dc.contributor.researcherid | D-6213-2013 | |
dc.contributor.researcherid | AAG-9177-2021 | |
dc.date.accessioned | 2024-06-05T12:27:21Z | |
dc.date.available | 2024-06-05T12:27:21Z | |
dc.date.issued | 2021-04-01 | |
dc.description.abstract | Background: Adiponectin (ApN) is a 244-amino acid protein mainly secreted from the adipose tissue and involved in various physiological functions. ApN exerts its metabolic effects by binding to two major receptors: adiponectin receptor-1 (Adipo-R1) and adiponectin receptor-2 (Adipo-R2). Recent studies have reported ApN's involvement in the progression of cancer. However, there are no studies evaluating the relationship between Adipo-R1/R2 expression and gastric intestinal metaplasia (IM), which is a predisposing factor in gastric cancer (GC) development, and Helicobacter pylori H. pylori infection. Aims: In this study we aimed to investigate the relationship between the Adipo-R1/-R2 expression and H. pylori infection in patients with GC and gastric IM. Materials and Methods: Forty patients that underwent gastric resection and 56 patients that developed gastric IM were included in the study. The Adipo-R1/-R2 expression and the presence of H. pylori were examined immunohistochemically. The univariate analyses showed that the expression of Adipo-R1/-R2 in GC patients was significantly lower compared to both complete metaplasia (CM) and incomplete metaplasia (ICM) patients (p <0.0001 for both). Results: According to multiple multinomial logistic regression analysis, Adipo-R1/-R2 expression in the CM group was significantly higher than in the GC group (p = 0.05, p = 0.014, respectively). Moreover, Adipo-R1/-R2 expression was significantly higher in ICM group compared to the GC group (p=0.012, p=0.045, respectively). However, in both analyses no significant difference was determined in terms of H. pylori positivity between the groups.Conclusion: The resulting data suggests that ApN plays a role in GC processes via Adipo-R1/-R2 receptors. | |
dc.identifier.doi | 10.4103/njcp.njcp_302_20 | |
dc.identifier.endpage | 613 | |
dc.identifier.issn | 1119-3077 | |
dc.identifier.issue | 4 | |
dc.identifier.startpage | 608 | |
dc.identifier.uri | https://doi.org/10.4103/njcp.njcp_302_20 | |
dc.identifier.uri | https://hdl.handle.net/11452/41779 | |
dc.identifier.volume | 24 | |
dc.identifier.wos | 000640572500022 | |
dc.indexed.wos | WOS.SCI | |
dc.language.iso | en | |
dc.publisher | Wolters Kluwer Medknow Publications | |
dc.relation.journal | Nigerian Journal Of Clinical Practice | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Adiponectin | |
dc.subject | Adipo-r1 | |
dc.subject | R2 | |
dc.subject | Gastric carcinoma | |
dc.subject | Intestinal metaplasia | |
dc.subject | Helicobacter pylori | |
dc.subject | Science & technology | |
dc.subject | Life sciences & biomedicine | |
dc.subject | Medicine, general & internal | |
dc.subject | General & internal medicine | |
dc.title | The expression and relationship of adipo R1/R2 in gastric intestinal metaplasia | |
dc.type | Article | |
dspace.entity.type | Publication | |
relation.isAuthorOfPublication | 9f100906-5262-4b98-9828-2958eac56d15 | |
relation.isAuthorOfPublication | dd613ef2-8621-4e20-8c27-0393f7c8e632 | |
relation.isAuthorOfPublication.latestForDiscovery | 9f100906-5262-4b98-9828-2958eac56d15 |
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