Publication:
The expression and relationship of adipo R1/R2 in gastric intestinal metaplasia

dc.contributor.authorAyyildiz, T.
dc.contributor.authorErturk, B.
dc.contributor.buuauthorDolar, E.
dc.contributor.buuauthorDOLAR, MAHMUT ENVER
dc.contributor.buuauthorUgras, N.
dc.contributor.buuauthorUĞRAŞ, NESRİN
dc.contributor.buuauthorDizdar, O. S.
dc.contributor.buuauthorAdim, S. B.
dc.contributor.buuauthorYerci, O.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Patoloji Anabilim Dalı.
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/Gastroentoloji Anabilim Dalı.
dc.contributor.researcheridD-6213-2013
dc.contributor.researcheridAAG-9177-2021
dc.date.accessioned2024-06-05T12:27:21Z
dc.date.available2024-06-05T12:27:21Z
dc.date.issued2021-04-01
dc.description.abstractBackground: Adiponectin (ApN) is a 244-amino acid protein mainly secreted from the adipose tissue and involved in various physiological functions. ApN exerts its metabolic effects by binding to two major receptors: adiponectin receptor-1 (Adipo-R1) and adiponectin receptor-2 (Adipo-R2). Recent studies have reported ApN's involvement in the progression of cancer. However, there are no studies evaluating the relationship between Adipo-R1/R2 expression and gastric intestinal metaplasia (IM), which is a predisposing factor in gastric cancer (GC) development, and Helicobacter pylori H. pylori infection. Aims: In this study we aimed to investigate the relationship between the Adipo-R1/-R2 expression and H. pylori infection in patients with GC and gastric IM. Materials and Methods: Forty patients that underwent gastric resection and 56 patients that developed gastric IM were included in the study. The Adipo-R1/-R2 expression and the presence of H. pylori were examined immunohistochemically. The univariate analyses showed that the expression of Adipo-R1/-R2 in GC patients was significantly lower compared to both complete metaplasia (CM) and incomplete metaplasia (ICM) patients (p <0.0001 for both). Results: According to multiple multinomial logistic regression analysis, Adipo-R1/-R2 expression in the CM group was significantly higher than in the GC group (p = 0.05, p = 0.014, respectively). Moreover, Adipo-R1/-R2 expression was significantly higher in ICM group compared to the GC group (p=0.012, p=0.045, respectively). However, in both analyses no significant difference was determined in terms of H. pylori positivity between the groups.Conclusion: The resulting data suggests that ApN plays a role in GC processes via Adipo-R1/-R2 receptors.
dc.identifier.doi10.4103/njcp.njcp_302_20
dc.identifier.endpage613
dc.identifier.issn1119-3077
dc.identifier.issue4
dc.identifier.startpage608
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_302_20
dc.identifier.urihttps://hdl.handle.net/11452/41779
dc.identifier.volume24
dc.identifier.wos000640572500022
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherWolters Kluwer Medknow Publications
dc.relation.journalNigerian Journal Of Clinical Practice
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectAdiponectin
dc.subjectAdipo-r1
dc.subjectR2
dc.subjectGastric carcinoma
dc.subjectIntestinal metaplasia
dc.subjectHelicobacter pylori
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectMedicine, general & internal
dc.subjectGeneral & internal medicine
dc.titleThe expression and relationship of adipo R1/R2 in gastric intestinal metaplasia
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication9f100906-5262-4b98-9828-2958eac56d15
relation.isAuthorOfPublicationdd613ef2-8621-4e20-8c27-0393f7c8e632
relation.isAuthorOfPublication.latestForDiscovery9f100906-5262-4b98-9828-2958eac56d15

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