Publication:
Slx5 deletion confers tolerance to oxidative stress in saccharomyces cerevisiae

dc.contributor.authorThomas, Pınar B.
dc.contributor.authorKaluç, Nur
dc.contributor.buuauthorAybastıer, Önder
dc.contributor.buuauthorAYBASTIER, ÖNDER
dc.contributor.departmentBursa Uludağ Üniversitesi/Fen Edebiyat Fakültesi/Kimya Bölümü.
dc.contributor.orcid0000-0002-0380-1992
dc.contributor.researcheridX-4621-2018
dc.date.accessioned2024-11-01T07:58:07Z
dc.date.available2024-11-01T07:58:07Z
dc.date.issued2022-09-01
dc.description.abstractSlx5, a subunit of a SUMO-targeted ubiquitin ligase (STUbL) in yeast, has been implicated in maintenance of genomic stability. SUMOylation is an important post-translational modification involved in the regulation of several important cellular processes and cellular response to various environmental stressors. Oxidative stress occurs when production of reactive oxygen species (ROS) exceeds the antioxidant defense capacity of the cell. Elevated ROS levels cause oxidative damage to important cellular macromolecules such as DNA, lipids, and proteins, which is associated with several diseases. Herein, we investigated the role of Slx5 in oxidative stress tolerance in Saccharomyces cerevisiae. We show that deletion of SLX5 increases survival of yeast cells in response to H2O2-induced oxidative stress in a cell cycle independent manner. Accumulation of intracellular ROS as well as DNA and lipid damages were reduced; expressions of antioxidant defense mechanism-related genes were increased in slx5 Delta cells compared to wild type (WT) under oxidative stress. We also show that slx5 Delta cells have increased intracellular ROS levels and oxidative damage to DNA and lipids compared to WT in the absence of oxidative stress. Thus, our data together suggest that an adaptive stress induced by SLX5 deletion increases tolerance to oxidative stress in slx5 increment cells.An adaptive stress induced by SLX5 deletion increases tolerance to oxidative stress in Saccharomyces cerevisiae.
dc.description.sponsorshipMaltepe University Scientific Research Projects Commission
dc.identifier.doi10.1093/femsle/fnac077
dc.identifier.issn0378-1097
dc.identifier.issue1
dc.identifier.urihttps://doi.org/10.1093/femsle/fnac077
dc.identifier.urihttps://hdl.handle.net/11452/47302
dc.identifier.volume369
dc.identifier.wos000848326100002
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherOxford Univ Press
dc.relation.journalFems Microbiology Letters
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectGene-expression
dc.subjectDna
dc.subjectSumoylation
dc.subjectProteins
dc.subjectComplex
dc.subjectDamage
dc.subjectRoles
dc.subjectPcr
dc.subjectSlx5
dc.subjectOxidative stress tolerance
dc.subjectAdaptive stress
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectMicrobiology
dc.titleSlx5 deletion confers tolerance to oxidative stress in saccharomyces cerevisiae
dc.typeArticle
dspace.entity.typePublication
relation.isAuthorOfPublication875c0dc3-9c4b-47a6-8052-c7f44f84fc9b
relation.isAuthorOfPublication.latestForDiscovery875c0dc3-9c4b-47a6-8052-c7f44f84fc9b

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