Publication:
Oxidative stress in dogs during mid-gestation abortion: Fetal and maternal antioxidant alterations with clinical and hematological features

dc.contributor.authorGül, Mehmet Zafer
dc.contributor.authorSeyidoğlu, Nilay
dc.contributor.buuauthorÖzalp, Gözde Rabia.
dc.contributor.buuauthorBüyükuysal, Levent
dc.contributor.buuauthorBÜYÜKUYSAL, RİFAT LEVENT
dc.contributor.buuauthorÖZALP, RABİA GÖZDE
dc.contributor.departmentVeteriner Fakültesi
dc.contributor.departmentFarmakoloji Ana Bilim Dalı
dc.contributor.researcheridDKN-0912-2022
dc.contributor.researcheridJHN-8745-2023
dc.date.accessioned2024-11-22T12:32:15Z
dc.date.available2024-11-22T12:32:15Z
dc.date.issued2022-04-01
dc.description.abstractThe present study aimed to evaluate the GSH and MDA levels in dog???s serum and vital organs of aborted fetuses, after application of two abortifacient. Animals of group I (n = 6) were treated twice with subcutaneous injection of 10 mg/kg aglepristone and group II (n = 3) received prostaglandin F2?? at a dose of 125 ??g/kg every 12 hours until abortion process completed. Hematologic examinations and sedimentation rates were performed of bitches. The duration between the first occurrence of vaginal discharge to first expulsion of fetuses ranged between 14-29 hours (mean: 22.6??5.5 h) and 24-33 hours in group I and II, respectively. Both treatments significantly increased the serum MDA levels (P<0.01); however aglepristone increased the MDA levels throughout the study, prostaglandin enhanced plasma MDA levels only on day 1. GSH levels were significantly lower in aglepristone-treated bitches than prostaglan-din-treated animals (P 0.05). The treatments resulted in similar MDA levels in liver and heart tissues (P 0.05). GSH levels in kidney, muscle and heart tissues did not differ between groups (P>0.05), aglepristone resulted reduced GSH levels in liver tissue (P<0.05). High MDA levels could be evaluated as a useful marker for fetal suffering in pregnancy controls. The MDA and GSH levels, measured in vital organs of fetuses, could suggest possible toxic effects of aborti-facients in newborns, as both medical agents are being used in parturition induction.
dc.identifier.doi10.12681/jhvms.26307
dc.identifier.endpage4048
dc.identifier.issn1792-2720
dc.identifier.issue2
dc.identifier.startpage4041
dc.identifier.urihttps://doi.org/10.12681/jhvms.26307
dc.identifier.urihttps://hdl.handle.net/11452/48381
dc.identifier.volume73
dc.identifier.wos000825157800017
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherHellenic Veterinary Medical Soc
dc.relation.journalJournal Of The Hellenic Veterinary Medical Society
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectProgesterone antagonist aglepristone
dc.subjectPregnancy termination
dc.subjectUnwanted pregnancy
dc.subjectMidterm pregnancy
dc.subjectDopamine agonist
dc.subjectVitamin-a
dc.subjectInduction
dc.subjectCombination
dc.subjectBitches
dc.subjectCloprostenol
dc.subjectPregnancy termination
dc.subjectMalondialdehyde
dc.subjectReduced glutathione
dc.subjectProstaglandin
dc.subjectAglepristone
dc.subjectDog
dc.subjectScience & technology
dc.subjectLife sciences & biomedicine
dc.subjectVeterinary sciences
dc.titleOxidative stress in dogs during mid-gestation abortion: Fetal and maternal antioxidant alterations with clinical and hematological features
dc.typeArticle
dspace.entity.typePublication
local.contributor.departmentVeteriner Fakültesi/Jinekoloji ve Doğum Ana Bilim Dalı
local.contributor.departmentTıp Fakültesi/Farmakoloji Ana Bilim Dalı
relation.isAuthorOfPublication01c69529-8892-4869-8d8c-5b95cf48b69c
relation.isAuthorOfPublication365bc240-97b6-4a40-9d05-c605d3375637
relation.isAuthorOfPublication.latestForDiscovery01c69529-8892-4869-8d8c-5b95cf48b69c

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