Publication:
Preemptive analgesic effects of intravenous paracetamol in total abdominal hysterectomy

dc.contributor.authorArıcı, Semih
dc.contributor.authorGurbet, Alp
dc.contributor.authorTürker, Gürkan
dc.contributor.authorYavaşcaoğlu, Belgin
dc.contributor.authorŞahin, Şükran
dc.contributor.buuauthorArıcı, Semih
dc.contributor.buuauthorGURBET, ALP
dc.contributor.buuauthorTÜRKER, YUNUS GÜRKAN
dc.contributor.buuauthorYAVAŞCAOĞLU, BELGİN
dc.contributor.buuauthorŞahin, Şükran
dc.contributor.departmentUludağ Üniversitesi/Tıp Fakültesi/Anestezi ve Reanimasyon Anabilim Dalı.
dc.contributor.orcid0000-0002-6503-8232
dc.contributor.orcid0000-0002-3019-581X
dc.contributor.orcid0000-0003-4820-2288
dc.contributor.researcheridA-7994-2018
dc.contributor.researcheridAAI-7914-2021
dc.contributor.researcheridJZE-5924-2024
dc.contributor.researcheridAAI-6642-2021
dc.contributor.researcheridAAG-9356-2021
dc.date.accessioned2024-09-18T08:10:27Z
dc.date.available2024-09-18T08:10:27Z
dc.date.issued2009-04-01
dc.description.abstractObjectives: Paracetamol is primarily thought to be a cyclooxygenase inhibitor acting through the central nervous system. Indirect effects of paracetamol are through the serotoninergic system as a non-opioid analgesic. In this study, total abdominal hysterectomy patients were given intravenous (iv) paracetamol 1 g preoperatively or intraoperatively to assess its postoperative analgesic effects.Methods: 90 patients undergoing total abdominal hysterectomy were enrolled into the study. Patients were randomized into three groups: in Group I, iv paracetamol 1 g was given 30 minutes prior to induction. In Group II, iv paracetamol 1 g was given prior to skin closure. Group III served as the control group and received saline as placebo. Postoperatively, all patients received morphine via patient-controlled analgesia pump. Postoperatively, rest and activity pain scores, sedation scores, hemodynamic parameters, postoperative morphine consumption, side effects, patient satisfaction, and total hospital stay were recorded.Results: In the control group, at rest and movement pain scores and total morphine consumption via patient-controlled analgesia were higher than in Groups I and II. When Groups I and II were compared, total morphine consumption was much greater in Group II. Intravenous paracetamol intraoperatively and postoperatively did not result in any hemodynamic effects.Conclusion: In total abdominal hysterectomy, preemptive iv paracetamol 1 g provided good quality postoperative analgesia, with decreased consumption of morphine and minimal side effects.
dc.identifier.endpage61
dc.identifier.issn1300-0012
dc.identifier.issue2
dc.identifier.startpage54
dc.identifier.urihttps://hdl.handle.net/11452/44875
dc.identifier.volume21
dc.identifier.wos000421060300002
dc.indexed.wosWOS.ESCI
dc.language.isoen
dc.publisherKare Publ
dc.relation.journalAgri-The Journal of The Turkish Society of Algology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/closedAccess
dc.subjectLaparotomy
dc.subjectMorphine
dc.subjectParacetamol
dc.subjectPostoperative analgesia
dc.subjectGeneral & internal medicine
dc.titlePreemptive analgesic effects of intravenous paracetamol in total abdominal hysterectomy
dc.typeArticle
dspace.entity.typePublication
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relation.isAuthorOfPublication22870513-5f1d-4e85-9a57-284c8900e112
relation.isAuthorOfPublication.latestForDiscoveryfc04310c-770b-4b0f-89a3-3ed0ffafbc66

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