Publication:
Systemic inflammatory indices for predicting prognosis of myelofibrosis

dc.contributor.authorErsal, Tuba
dc.contributor.authorÖzkocaman, Vildan
dc.contributor.authorPınar, İbrahim Ethem
dc.contributor.authorYalçın, Cumali
dc.contributor.authorOrhan, Bedrettin
dc.contributor.authorCandar, Ömer
dc.contributor.authorÇubukcu, Sinem
dc.contributor.authorKoca, Tuba Güllü
dc.contributor.authorHunutlu, Fazıl Çağrı
dc.contributor.authorYavuz, Şeyma
dc.contributor.authorAli, Ridvan
dc.contributor.authorÖzkalemkaş, Fahir
dc.contributor.buuauthorERSAL, TUBA
dc.contributor.buuauthorÖZKOCAMAN, VİLDAN
dc.contributor.buuauthorPINAR, İBRAHİM ETHEM
dc.contributor.buuauthorYALÇIN, CUMALİ
dc.contributor.buuauthorORHAN, BEDRETTİN
dc.contributor.buuauthorCANDAR, ÖMER
dc.contributor.buuauthorÇUBUKÇU, SİNEM
dc.contributor.buuauthorGÜLLÜ KOCA, TÛBA
dc.contributor.buuauthorHUNUTLU, FAZIL ÇAĞRI
dc.contributor.buuauthorYAVUZ, ŞEYMA
dc.contributor.buuauthorALİ, RIDVAN
dc.contributor.buuauthorÖZKALEMKAŞ, FAHİR
dc.contributor.departmentBursa Uludağ Üniversitesi/Tıp Fakültesi/İç Hastalıkları Anabilim Dalı/Hematoloji Bilim Dalı.
dc.contributor.orcid0000-0001-9907-1498
dc.contributor.orcid0000-0003-4168-2821
dc.contributor.orcid0000-0003-3970-2344
dc.contributor.orcid0000-0002-4991-9830
dc.contributor.researcheridAAJ-4354-2021
dc.contributor.researcheridFQG-8981-2022
dc.contributor.researcheridJGM-6601-2023
dc.contributor.researcheridKIE-5102-2024
dc.contributor.researcheridACW-2157-2022
dc.contributor.researcheridEOZ-1609-2022
dc.contributor.researcheridJJB-0254-2023
dc.contributor.researcheridGWQ-5007-2022
dc.contributor.researcheridKCK-7512-2024
dc.contributor.researcheridGXS-5860-2022
dc.contributor.researcheridGXD-8209-2022
dc.contributor.researcheridJIW-1248-2023
dc.date.accessioned2024-09-30T12:42:17Z
dc.date.available2024-09-30T12:42:17Z
dc.date.issued2023-08-02
dc.description.abstractThe impact of inflammatory markers such as systemic immune-inflammation (SII) index and systemic inflammation response index (SIRI) on myelofibrosis (MF) prognosis was evaluated for the first time in this study. Data from 60 patients diagnosed with MF between March 2011 and September 2022 were retrospectively analyzed. In addition to disease-related markers, the impact of SII and SIRI on prognosis was evaluated. In our study, the overall median survival (OS) was 64 months. OS was significantly shorter in patients older than 65 years, with high ferritin and lymphocyte levels, transfusion dependence at diagnosis, platelet count below 100 x 10(9)/L, Hb level below 8 g/dl, and high risk according to the dynamic international prognostic scoring system (DIPSS)-Plus score. When these variables were included in the multivariate Cox regression model, it was found that being older than 65 years, having a high ferritin value, being at high risk according to the DIPSS-plus score and Hb values below 8 increased the risk of death. Platelet-to-lymphocyte ratio (PLR) and SII index were lower in patients with a fatal outcome. No statistically significant relationship was found between SIRI and mortality. The findings of this study showed that low PLR and high ferritin were associated with poor prognosis in MF. Elevated SII and SIRI, evaluated for the first time in patients with myelofibrosis, did not predict prognosis. Since non-inflammatory variables play a role in the pathogenesis of MF, bone marrow indicators and systemic inflammation indicators derived from hematologic parameters may not be accurate.
dc.identifier.doi10.1038/s41598-023-39077-7
dc.identifier.issn2045-2322
dc.identifier.issue1
dc.identifier.urihttps://doi.org/10.1038/s41598-023-39077-7
dc.identifier.urihttps://www.nature.com/articles/s41598-023-39077-7
dc.identifier.urihttps://hdl.handle.net/11452/45529
dc.identifier.volume13
dc.identifier.wos001042088200023
dc.indexed.wosWOS.SCI
dc.language.isoen
dc.publisherNature Portfolio
dc.relation.journalScientific Reports
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi
dc.rightsinfo:eu-repo/semantics/openAccess
dc.subjectC-reactive protein
dc.subjectInternational working group
dc.subjectTransfusion-dependency
dc.subjectPoor survival
dc.subjectCancer
dc.subjectDiagnosis
dc.subjectRatio
dc.subjectBiomarkers
dc.subjectNeoplasms
dc.subjectSiri
dc.subjectScience & technology - other topics
dc.titleSystemic inflammatory indices for predicting prognosis of myelofibrosis
dc.typeArticle
dspace.entity.typePublication
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